(Q42804994)

English

Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells

scientific article published on 18 February 2003

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scholarly article

1 reference

Europe PubMed Central

7 November 2017

Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells (English)

1 reference

Europe PubMed Central

7 November 2017

1 reference

based on heuristic

inferred from title

desensitization

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

7 November 2017

author name string

Stephanie Bonnafous

2

1 reference

Europe PubMed Central

7 November 2017

Anne M Johnston

3

1 reference

Europe PubMed Central

7 November 2017

Claire Chaussade

4

1 reference

Europe PubMed Central

7 November 2017

Fiorella Portis

5

1 reference

Europe PubMed Central

7 November 2017

Emmanuel Van Obberghen

6

1 reference

Europe PubMed Central

7 November 2017

language of work or name

0 references

publication date

18 February 2003

1 reference

Europe PubMed Central

7 November 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

7 November 2017

278

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Europe PubMed Central

7 November 2017

18

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Europe PubMed Central

7 November 2017

15641-15651

1 reference

Europe PubMed Central

7 November 2017

New perspectives into the molecular pathogenesis and treatment of type 2 diabetes

1 reference

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21 January 2018

Triglycerides, fatty acids and insulin resistance--hyperinsulinemia

1 reference

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21 January 2018

Specific features of glycogen metabolism in the liver

1 reference

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21 January 2018

Mechanisms of nutritional and hormonal regulation of lipogenesis

1 reference

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21 January 2018

The insulin signalling system and the IRS proteins

1 reference

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21 January 2018

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

1 reference

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21 January 2018

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Oncogenic kinase signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Impaired autophosphorylation of insulin receptors from abdominal skeletal muscles in nonobese subjects with NIDDM.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes

1 reference

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21 January 2018

Elevation of serum insulin concentration during euglycemic hyperinsulinemic clamp studies leads to similar activation of insulin receptor kinase in skeletal muscle of subjects with and without NIDDM.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Insulin stimulates the degradation of IRS-1 in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Wortmannin and LY294002 inhibit the insulin-induced down-regulation of IRS-1 in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

1 reference

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21 January 2018

A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Sustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Insulin-mediated cellular insulin resistance decreases osmotic shock-induced glucose transport in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

A simplified system for generating recombinant adenoviruses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Stimulation of glucose and amino acid transport and activation of the insulin signaling pathways by insulin lispro in L6 skeletal muscle cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Disruption of 3-phosphoinositide-dependent kinase 1 (PDK1) signaling by the anti-tumorigenic and anti-proliferative agent n-alpha-tosyl-l-phenylalanyl chloromethyl ketone

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

PTEN expression causes feedback upregulation of insulin receptor substrate 2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Components of signaling pathways for insulin and insulin-like growth factor-I in muscle myoblasts and myotubes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1.

1 reference

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21 January 2018

3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling

1 reference

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21 January 2018

Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes

1 reference

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21 January 2018

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1 reference

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21 January 2018

Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208984200

21 January 2018

The role of PI 3-kinase in insulin action

1 reference

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21 January 2018

Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M208984200

1 reference

Europe PubMed Central

7 November 2017

1 reference

Europe PubMed Central

7 November 2017

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