(Q40816988)

English

Disruption of 3-phosphoinositide-dependent kinase 1 (PDK1) signaling by the anti-tumorigenic and anti-proliferative agent n-alpha-tosyl-l-phenylalanyl chloromethyl ketone

scientific article published on 18 January 2001

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scholarly article

1 reference

Europe PubMed Central

24 September 2017

Disruption of 3-phosphoinositide-dependent kinase 1 (PDK1) signaling by the anti-tumorigenic and anti-proliferative agent n-alpha-tosyl-l-phenylalanyl chloromethyl ketone (English)

1 reference

Europe PubMed Central

24 September 2017

author name string

Ballif BA

1

1 reference

Europe PubMed Central

24 September 2017

Shimamura A

2

1 reference

Europe PubMed Central

24 September 2017

Pae E

3

1 reference

Europe PubMed Central

24 September 2017

Blenis J

4

1 reference

Europe PubMed Central

24 September 2017

language of work or name

0 references

publication date

18 January 2001

1 reference

Europe PubMed Central

24 September 2017

number of pages

10

1 reference

based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

24 September 2017

276

1 reference

Europe PubMed Central

24 September 2017

12466-12475

1 reference

Europe PubMed Central

24 September 2017

15

1 reference

Europe PubMed Central

24 September 2017

Intracellular signalling: PDK1--a kinase at the hub of things

1 reference

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21 January 2018

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

1 reference

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21 January 2018

Cellular signaling: pivoting around PDK-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

Three protein kinase structures define a common motif

1 reference

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21 January 2018

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

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21 January 2018

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

Phosphorylation and activation of p70s6k by PDK1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

1 reference

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21 January 2018

Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

1 reference

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21 January 2018

Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta

1 reference

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21 January 2018

Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase

1 reference

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21 January 2018

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

1 reference

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21 January 2018

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

1 reference

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21 January 2018

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK.

1 reference

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21 January 2018

90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

1 reference

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21 January 2018

Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase

1 reference

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21 January 2018

Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1.

1 reference

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21 January 2018

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

1 reference

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21 January 2018

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

Dual role of pseudosubstrate in the coordinated regulation of protein kinase C by phosphorylation and diacylglycerol

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

Ribosomal S6 kinase signaling and the control of translation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

Tumorigenesis in Mouse Skin: Inhibition by Synthetic Inhibitors of Proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

The effect of epsilon amino caproic acid and other inhibitors of proteolysis upon the response of human peripheral blood lymphocytes to phytohemagglutinin

1 reference

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21 January 2018

Non-selective inhibition of transformed cell growth by a protease inhibitor

1 reference

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21 January 2018

Studies on mechanism of action of anti-tumor-promoting agents: their specificity in two-stage promotion

1 reference

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21 January 2018

Suppression of phorbol ester-enhanced radiation-induced malignancy in vitro by protease inhibitors is independent of protein kinase C.

1 reference

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21 January 2018

N-acetylcysteine blocks apoptosis induced by N-alpha-tosyl-L-phenylalanine chloromethyl ketone in transformed T-cells

1 reference

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21 January 2018

The serine protease inhibitors, tosylphenylalanine chloromethyl ketone and tosyllysine chloromethyl ketone, potently inhibit pp70s6k activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

Rsk1 mediates a MEK-MAP kinase cell survival signal

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

Evidence for two catalytically active kinase domains in pp90rsk

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

Structural and functional analysis of pp70S6k

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

1 reference

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21 January 2018

Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.

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21 January 2018

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

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21 January 2018

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

1 reference

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21 January 2018

Drosophila S6 kinase: a regulator of cell size

1 reference

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21 January 2018

Affinity labeling of the catalytic subunit of cyclic AMP-dependent protein kinase by N alpha-tosyl-L-lysine chloromethyl ketone

1 reference

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21 January 2018

Kinase phosphorylation: Keeping it all in the family

1 reference

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21 January 2018

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

1 reference

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21 January 2018

14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation

1 reference

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21 January 2018

Phosphorylation of the pro-apoptotic protein BAD on serine 155, a novel site, contributes to cell survival

1 reference

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21 January 2018

Chemopreventive agents: protease inhibitors.

1 reference

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21 January 2018

Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

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21 January 2018

Prevention of vertebrate neuronal death by the crmA gene

1 reference

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21 January 2018

N-alpha-Tosyl-L-lysine chloromethyl ketone and N-alpha-tosyl-L-phenylalanine chloromethyl ketone inhibit protein kinase C.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009939200

21 January 2018

The serine protease inhibitors TLCK and TPCK react with the RB-binding core of HPV-18 E7 protein and abolish its RB-binding capability

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21 January 2018

Inhibition of c-myc expression induces apoptosis of WEHI 231 murine B cells

1 reference

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21 January 2018

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

1 reference

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21 January 2018

IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase

1 reference

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21 January 2018

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

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21 January 2018

Identifiers

10.1074/JBC.M009939200

1 reference

Europe PubMed Central

24 September 2017

1 reference

Europe PubMed Central

24 September 2017

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