(Q39229398)

10 September 2017

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title

Tomudex (ZD1694): from concept to care, a programme in rational drug discovery (English)

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10 September 2017

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A L Jackman

1

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10 September 2017

F T Boyle

series ordinal

2

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10 September 2017

K R Harrap

series ordinal

3

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10 September 2017

publication date

1 January 1996

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Investigational New Drugs

10 September 2017

published in

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10 September 2017

volume

14

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10 September 2017

issue

3

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10 September 2017

page(s)

305-316

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https://scigraph.springernature.com/pub.10.1007/bf00194534

10 September 2017

exact match

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cites work

Inhibition of the growth of human hepatocellular carcinoma in vitro and in athymic mice by a quinazoline inhibitor of thymidylate synthase, CB3717.

1 reference

https://api.crossref.org/works/10.1007%2FBF00194534

Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00194534

The renal effects of N10-propargyl-5,8-dideazafolic acid (CB3717) and a non-nephrotoxic analogue ICI D1694, in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00194534

Phase II study of the thymidylate synthetase inhibitor CB3717 (N10-propargyl-5,8-dideazafolic acid) in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00194534

Correlation between cell enlargement and nucleic acid and protein content of HeLa cells in unbalanced growth produced by inhibitors of DNA synthesis

21 January 2018

1 reference

12 December 2020

A clinical-pharmacological evaluation of hepatic arterial infusions of 5-fluoro-2'-deoxyuridine and 5-fluorouracil

1 reference

12 December 2020

Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinomas in mice

1 reference

12 December 2020

Formation and retention and biological activity of N10-propargyl-5,8-dideazafolic acid (CB3717) polyglutamates in L1210 cells in vitro

1 reference

12 December 2020

Enhancement of the therapeutic effectiveness of methotrexate and protection of normal proliferating tissues with purines and pyrimidines

1 reference

12 December 2020

Studies on resistance against 5-fluorouracil. I. Enzymes of the uracil pathway during development of resistance

1 reference

12 December 2020

Biochemical determinants of 5-fluorouracil response in vivo. The role of deoxyuridylate pool expansion

1 reference

12 December 2020

Karnofsky memorial lecture. Ode to methotrexate

1 reference

12 December 2020

Physiological and pharmacological determinants of sensitivity and resistance to 5-fluorouracil in lower animals and man.

1 reference

12 December 2020

Preclinical and clinical aspects of biomodulation of 5-fluorouracil

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12 December 2020

Biochemical factors affecting the tightness of 5-fluorodeoxyuridylate binding to human thymidylate synthetase

1 reference

12 December 2020

The biochemical pharmacology of the thymidylate synthase inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)

1 reference

12 December 2020

Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position

1 reference

12 December 2020

Enhanced cytotoxicity with methotrexate in conjunction with hypoxanthine in L1210 cells in culture

1 reference

12 December 2020

Thymidylate synthase inhibitors: the in vitro activity of a series of heterocyclic benzoyl ring modified 2-desamino-2-methyl-N10-substituted-5,8-dideazafolates

1 reference

12 December 2020

Relationships between resistance to cisplatin and antifolates in sensitive and resistant tumour cell lines

1 reference

12 December 2020

'Tomudex' (ZD1694): A novel thymidylate synthase inhibitor with clinical antitumour activity in a range of solid tumours

1 reference

12 December 2020

‘Tomudex’ (ZD1694): Results of a randomised trial in advanced colorectal cancer demonstrate efficacy and reduced mucositis and leucopenia

1 reference

12 December 2020

2-amino-4-hydroxyquinazolines as inhibitors of thymidylate synthetase

1 reference

12 December 2020

The regulation of thymidylate biosynthesis in Novikoff hepatoma cells and the effects of amethopterin, 5-fluorodeoxyuridine, and 3-deazauridine

1 reference

12 December 2020

Quinazoline-based thymidylate synthase inhibitors: relationship between structural modifications and polyglutamation

1 reference

12 December 2020

Rapid determination of thymidylate synthase activity and its inhibition in intact L1210 leukemia cells in vitro

1 reference

12 December 2020

Effects of 5-fluorouracil on 5-fluorodeoxyuridine 5'-monophosphate and 2-deoxyuridine 5'-monophosphate pools, and DNA synthesis in solid mouse L1210 and rat Walker 256 tumors

1 reference

12 December 2020

Use of murine L5178Y lymphoma thymidine kinase mutants for in vitro and in vivo antitumour efficacy evaluation of novel thymidylate synthase inhibitors.

1 reference

12 December 2020

Quinazoline antifolates inhibiting thymidylate synthase: synthesis of four oligo(L-gamma-glutamyl) conjugates of N10-propargyl-5,8-dideazafolic acid and their enzyme inhibition

1 reference

12 December 2020

ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study

1 reference

12 December 2020

Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position

1 reference

12 December 2020

Biochemical and cell cycle perturbations in methotrexate-treated cells

1 reference

12 December 2020

ZD1694 (Tomudex): A new thymidylate synthase inhibitor with activity in colorectal cancer

1 reference

12 December 2020

Cell killing studies on the mode of action of methotrexate on L-cells in vitro

1 reference

12 December 2020

Analysis of the role of membrane transport and polyglutamation of methotrexate in gut and the Ehrlich tumor in vivo as factors in drug sensitivity and selectivity

1 reference

12 December 2020

The measurement of polyglutamate metabolites of the thymidylate synthase inhibitor, ICI D1694, in mouse and human cultured cells

1 reference

12 December 2020

Cellular pharmacokinetics of ZD1694 in cultured human leukaemia cells sensitive, or made resistant, to this drug

1 reference

12 December 2020

Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo

1 reference

12 December 2020

A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice

1 reference

12 December 2020

Thymidylate synthase: a target for anticancer drug design

1 reference

12 December 2020

Acquired methotrexate resistance in lymphoblasts resulting from altered kinetic properties of dihydrofoltate reductase

1 reference

12 December 2020

Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications

1 reference

12 December 2020

Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, N-(4-(N-(( 2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino) benzoyl)-L-glutamic acid (CB3717), on human lymphoblastoid cells

1 reference

12 December 2020

Activity of the thymidylate synthase inhibitor 2-desamino-N10-propargyl-5,8-dideazafolic acid and related compounds in murine (L1210) and human (W1L2) systems in vitro and in L1210 in vivo

1 reference

12 December 2020

The clinical pharmacokinetics of the novel antifolate N10-propargyl-5,8-dideazafolic acid (CB 3717)

1 reference

12 December 2020

In vivo rates of pyrimidine nucleotide metabolism in intact mouse T-lymphoma (s-49) cells treated with 5-fluorouracil.

1 reference

12 December 2020

Pharmacokinetics of the thymidylate synthase inhibitor N10-propargyl-5,8-dideazafolic acid (CB3717) in the mouse

1 reference

12 December 2020

Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potency

1 reference

12 December 2020

The pharmacology of the fluoropyrimidines

1 reference

12 December 2020

The pharmacokinetics of the quinazoline antifolate ICI D 1694 in mice and rats

1 reference

12 December 2020

Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity

1 reference

12 December 2020

The influence of drug-exposure conditions on the development of resistance to methotrexate or ZD1694 in cultured human leukaemia cells

1 reference

12 December 2020

Modulation of anti-metabolite effects. Effects of thymidine on the efficacy of the quinazoline-based thymidylate synthetase inhibitor, CB3717

1 reference

12 December 2020

Cytotoxicity of antifolate inhibitors of thymidylate and purine synthesis to WiDr colonic carcinoma cells

1 reference

12 December 2020

Quinazoline thymidylate synthase inhibitors: methods for assessing the contribution of polyglutamation to their in vitro activity.

1 reference

12 December 2020

Phase I trial of ZD1694, a new folate-based thymidylate synthase inhibitor, in patients with solid tumors

1 reference

12 December 2020

Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate

1 reference

12 December 2020

Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate

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12 December 2020

Chemotherapeutic strategies in metastatic colorectal cancer: an overview of current clinical trials

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12 December 2020

Folate-based thymidylate synthase inhibitors as anticancer drugs

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12 December 2020

Studies on unbalanced growth in tissue culture. I. Induction and consequences of thymidine deficiency

1 reference

12 December 2020

Quinazoline antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series

1 reference

12 December 2020

Activity of the new antifolate N10-propargyl-5,8-dideazafolate and its polyglutamates against human dihydrofolate reductase, human thymidylate synthetase, and KB cells containing different levels of dihydrofolate reductase.

1 reference

12 December 2020

STUDIES ON TUMOR RESISTANCE TO 5-FLUOROURACIL

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12 December 2020

New folate analogs of the 10-deaza-aminopterin series. Basis for structural design and biochemical and pharmacologic properties

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12 December 2020

Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF00194534

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10 September 2017

1 reference