(Q39231387)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28393922%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

title

Mitochondrial DNA in innate immune responses and inflammatory pathology (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28393922%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

0 references

0 references

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28393922%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

author name string

Gerald S Shadel

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28393922%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

publication date

10 April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28393922%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Immunology

17 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28393922%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

volume

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28393922%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28393922%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

page(s)

363-375

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28393922%20AND%20SRC:MED&resulttype=core&format=json

Mitochondrial form and function

17 March 2020

cites work

1 reference

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Mitochondrial DNA maintenance in vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondrial ROS signaling in organismal homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondria in innate immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondria in the regulation of innate and adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases

21 January 2018

1 reference

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The Mitochondrial Proteome and Human Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Initiation and beyond: multiple functions of the human mitochondrial transcription machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Regionally specific and genome-wide analyses conclusively demonstrate the absence of CpG methylation in human mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Methylation of mitochondrial DNA is not a useful marker for cancer detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

The control region of mitochondrial DNA shows an unusual CpG and non-CpG methylation pattern

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Methylation pattern of mouse mitochondrial DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Differential methylation of mitochondrial and nuclear DNA in cultured mouse, hamster and virus-transformed hamster cells. In vivo and in vitro methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

In vivo methylation of mtDNA reveals the dynamics of protein-mtDNA interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

High-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Hydroxymethyl cytosine marks in the human mitochondrial genome are dynamic in nature

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

DNA methylation on N(6)-adenine in mammalian embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Accessorizing the human mitochondrial transcription machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Minimizing the damage: repair pathways keep mitochondrial DNA intact

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondrial dysfunction due to oxidative mitochondrial DNA damage is reduced through cooperative actions of diverse proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Protecting the mitochondrial powerhouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondrial transcription factor A serves as a danger signal by augmenting plasmacytoid dendritic cell responses to DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Nucleic acid recognition by the innate immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Circulating mitochondrial DAMPs cause inflammatory responses to injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondrial DNA is released by shock and activates neutrophils via p38 map kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll-like receptor 9

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Parkinson's Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Converging roles of caspases in inflammasome activation, cell death and innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondrial DNA has a pro-inflammatory role in AMD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Ambiguities in NLRP3 inflammasome regulation: is there a role for mitochondria?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondrial DNA variation in human radiation and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mutation in cytochrome b gene of mitochondrial DNA in a family with fibromyalgia is associated with NLRP3-inflammasome activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Severe septic patients with mitochondrial DNA haplogroup JT show higher survival rates: a prospective, multicenter, observational study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial-nuclear interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Recognition of Endogenous Nucleic Acids by the Innate Immune System

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

STING: infection, inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Aicardi-Goutières syndrome and the type I interferonopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondrial DNA fragments released through the permeability transition pore correspond to specific gene size

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondrial permeability transition triggers the release of mtDNA fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Cyclosporin A inhibits the early phase of NF-kappaB/RelA activation induced by CD28 costimulatory signaling to reduce the IL-2 expression in human peripheral T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Innate immune recognition of mtDNA--an undercover signal?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Cell death disguised: The mitochondrial permeability transition pore as the c-subunit of the F(1)F(O) ATP synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Membrane-associated DNA transport machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

The conjugative DNA translocase TrwB is a structure-specific DNA-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondrial DNA stress primes the antiviral innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Association of a protein structure of probable membrane derivation with HeLa cell mitochondrial DNA near its origin of replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Replication of animal mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Herpes simplex virus eliminates host mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Herpes simplex virus UL12.5 targets mitochondria through a mitochondrial localization sequence proximal to the N terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Elimination of mitochondrial DNA is not required for herpes simplex virus 1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Type I interferons in infectious disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondrial DNA neutrophil extracellular traps are formed after trauma and subsequent surgery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Oxidative modification enhances the immunostimulatory effects of extracellular mitochondrial DNA on plasmacytoid dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

In D-loop: 40 years of mitochondrial 7S DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondrial DNA replication proceeds via a 'bootlace' mechanism involving the incorporation of processed transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

The genomic landscape of polymorphic human nuclear mitochondrial insertions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Fidelity of capture-enrichment for mtDNA genome sequencing: influence of NUMTs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Targeted and robust amplification of mitochondrial DNA in the presence of nuclear-encoded mitochondrial pseudogenes using Φ29 DNA polymerases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Preventing the pollution of mitochondrial datasets with nuclear mitochondrial paralogs (numts).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Cytosolic RNA:DNA hybrids activate the cGAS-STING axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondrial DNA released by trauma induces neutrophil extracellular traps

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondrial DNA: An Endogenous Trigger for Immune Paralysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Induction of type I IFN is a physiological immune reaction to apoptotic cell-derived membrane microparticles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Identification of novel oligonucleotides from mitochondrial DNA that spontaneously induce plasmacytoid dendritic cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Role of Mitochondrial DNA in Septic AKI via Toll-Like Receptor 9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondrial DNA damage-associated molecular patterns mediate a feed-forward cycle of bacteria-induced vascular injury in perfused rat lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondrial DNA-LL-37 Complex Promotes Atherosclerosis by Escaping from Autophagic Recognition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Investigating mitochondria as a target for treating age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Mitochondrial DNA damage as a potential mechanism for age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Circulating TNF and mitochondrial DNA are major determinants of neutrophil phenotype in the advanced-age, frail elderly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

5-methylcytidylic acid: absence from mitochondrial DNA of frogs and HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Neutrophil Extracellular Trap Mitochondrial DNA and Its Autoantibody in Systemic Lupus Erythematosus and a Proof-of-Concept Trial of Metformin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

Cyclosporine and tacrolimus have inhibitory effects on toll-like receptor signaling after liver transplantation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.21

inferred from DOI database lookup

7 January 2021

based on heuristic

Mitochondrial DNA in mortal and immortal human cells. Genome number, integrity, and methylation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28393922

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI.2017.21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28393922%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference