(Q39251887)

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Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity

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scholarly article

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Europe PubMed Central

10 September 2017

Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity (English)

1 reference

Europe PubMed Central

10 September 2017

apoptotic process

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pancreatic cancer

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based on heuristic

inferred from title

1

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Europe PubMed Central

10 September 2017

author name string

S Sebens

2

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Europe PubMed Central

10 September 2017

S Krebs

3

1 reference

Europe PubMed Central

10 September 2017

C Geismann

4

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Europe PubMed Central

10 September 2017

M Grossmann

5

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Europe PubMed Central

10 September 2017

M-L Kruse

6

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Europe PubMed Central

10 September 2017

S Schreiber

7

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Europe PubMed Central

10 September 2017

H Schäfer

8

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Europe PubMed Central

10 September 2017

language of work or name

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publication date

29 October 2012

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Europe PubMed Central

10 September 2017

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Europe PubMed Central

10 September 2017

32

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Europe PubMed Central

10 September 2017

40

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Europe PubMed Central

10 September 2017

4825-4835

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Europe PubMed Central

10 September 2017

https://scigraph.springernature.com/pub.10.1038/onc.2012.493

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Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2).

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Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells.

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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

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Nuclear factor (erythroid-derived 2)-like 2 regulates drug resistance in pancreatic cancer cells

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High levels of Nrf2 determine chemoresistance in type II endometrial cancer

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NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α.

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Increased expression of Nrf2/ARE-dependent anti-oxidant proteins in tamoxifen-resistant breast cancer cells.

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Keap1 mutations and Nrf2 pathway activation in epithelial ovarian cancer

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Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

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Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

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Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features

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Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

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Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues

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miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells

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A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity

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Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2.

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Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

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A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders

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Inflammatory macrophages induce Nrf2 transcription factor-dependent proteasome activity in colonic NCM460 cells and thereby confer anti-apoptotic protection

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Nrf2-ARE stress response mechanism: a control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases

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Proteasome inhibition induces a p38 MAPK pathway-dependent antiapoptotic program via Nrf2 in thyroid cancer cells

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21 January 2018

Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance.

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Acquisition of doxorubicin resistance in ovarian carcinoma cells accompanies activation of the NRF2 pathway

1 reference

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The Nrf2-Keap1-ARE signaling pathway: The regulation and dual function of Nrf2 in cancer.

1 reference

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21 January 2018

The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma

1 reference

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Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer

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Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

1 reference

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21 January 2018

Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling Pathway

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Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts

1 reference

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Hepatitis B virus induces expression of antioxidant response element-regulated genes by activation of Nrf2.

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Induction of 26S proteasome subunit PSMB5 by the bifunctional inducer 3-methylcholanthrene through the Nrf2-ARE, but not the AhR/Arnt-XRE, pathway

1 reference

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21 January 2018

Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter

1 reference

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21 January 2018

Dual roles of Nrf2 in cancer

1 reference

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21 January 2018

Oxidative stress, inflammation, and cancer: how are they linked?

1 reference

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Lung cancer signatures in plasma based on proteome profiling of mouse tumor models

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NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

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Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults

1 reference

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Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

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Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

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ERRbeta: a potent inhibitor of Nrf2 transcriptional activity

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Low and high dose UVB regulation of transcription factor NF-E2-related factor 2.

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Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop

1 reference

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Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin

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HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA.

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Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1

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Prothymosin-alpha mediates nuclear import of the INrf2/Cul3 Rbx1 complex to degrade nuclear Nrf2.

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Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells

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Feedback regulation of proteasome gene expression and its implications in cancer therapy

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The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress

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Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance

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Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on incretin hormones

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Increased expression of the E3-ubiquitin ligase receptor subunit betaTRCP1 relates to constitutive nuclear factor-kappaB activation and chemoresistance in pancreatic carcinoma cells

1 reference

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Mutation of the Nrf2 gene in non-small cell lung cancer

1 reference

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31 March 2020

Increased proteasome activity, ubiquitin-conjugating enzymes, and eEF1A translation factor detected in breast cancer tissue

1 reference

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Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression

1 reference

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Functional differences between two major ubiquitin receptors in the proteasome; S5a and hRpn13

1 reference

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31 March 2020

Identifiers

10.1038/ONC.2012.493

1 reference

Europe PubMed Central

10 September 2017

1 reference

Europe PubMed Central

10 September 2017

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