(Q39275998)

10 September 2017

title

p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO. (English)

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10 September 2017

Yuri Shibata

1

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10 September 2017

Masaaki Oyama

2

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10 September 2017

Hiroko Kozuka-Hata

3

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10 September 2017

Xiao Han

4

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10 September 2017

Yuetsu Tanaka

5

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10 September 2017

Jin Gohda

6

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10 September 2017

Jun-ichiro Inoue

7

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10 September 2017

language of work or name

English

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publication date

1 January 2012

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10 September 2017

published in

Nature Communications

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10 September 2017

volume

3

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10 September 2017

page(s)

1061

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Expanding role of ubiquitination in NF-κB signaling

10 September 2017

cites work

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12 December 2020

The UBX domain: a widespread ubiquitin-like module

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12 December 2020

Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation

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12 December 2020

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

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12 December 2020

CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes

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12 December 2020

The Ubx2 and Ubx3 cofactors direct Cdc48 activity to proteolytic and nonproteolytic ubiquitin-dependent processes

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12 December 2020

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

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12 December 2020

Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles

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12 December 2020

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

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12 December 2020

A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.

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12 December 2020

Cdc48/p97 and Shp1/p47 regulate autophagosome biogenesis in concert with ubiquitin-like Atg8

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12 December 2020

The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway

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12 December 2020

Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

1 reference

12 December 2020

CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

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12 December 2020

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

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12 December 2020

RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis

1 reference

12 December 2020

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

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12 December 2020

A role for NBR1 in autophagosomal degradation of ubiquitinated substrates

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12 December 2020

Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation

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12 December 2020

NF-kappaB activation in development and progression of cancer

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12 December 2020

The AAA team: related ATPases with diverse functions

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12 December 2020

Activation of the IκB kinase complex by HTLV-1 Tax requires cytosolic factors involved in Tax-induced polyubiquitination.

1 reference

12 December 2020

Role of p97 and syntaxin 5 in the assembly of transitional endoplasmic reticulum.

1 reference

12 December 2020

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

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12 December 2020

Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes

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12 December 2020

The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO

1 reference

12 December 2020

Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses

1 reference

12 December 2020

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

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12 December 2020

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

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12 December 2020

Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling

1 reference

12 December 2020

Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a new NEMO mutation causing incontinentia pigmenti.

1 reference

12 December 2020

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

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12 December 2020

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

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12 December 2020

Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

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12 December 2020

Controlling the fate of NIK: a central stage in noncanonical NF-kappaB signaling

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12 December 2020

Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4.

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12 December 2020

The localization and phosphorylation of p47 are important for Golgi disassembly-assembly during the cell cycle

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12 December 2020

NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain

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12 December 2020

Cutting edge: K63-linked polyubiquitination of NEMO modulates TLR signaling and inflammation in vivo

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12 December 2020

Role of the NF-kappaB pathway in the pathogenesis of human disease states

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12 December 2020

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

1 reference

12 December 2020

Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation

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12 December 2020

NF-kappaB: a key role in inflammatory diseases

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12 December 2020

Linear polyubiquitination: a new regulator of NF-kappaB activation.

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12 December 2020

Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-kappaB, as a strategy for chemoprevention and therapy of adult T-cell leukemia

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12 December 2020

Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly.

1 reference

12 December 2020

A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme

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12 December 2020

Isolation of a point-mutated p47 lacking binding affinity to p97ATPase

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12 December 2020

Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding

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12 December 2020

p47 is a cofactor for p97-mediated membrane fusion

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12 December 2020

Direct, noncatalytic mechanism of IKK inhibition by A20.

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12 December 2020

Direct activation of protein kinases by unanchored polyubiquitin chains

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12 December 2020

Valosin-containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway substrates in mammalian cells

1 reference

12 December 2020

Polycomb-mediated loss of miR-31 activates NIK-dependent NF-κB pathway in adult T cell leukemia and other cancers.

1 reference

12 December 2020

"Without Ub I am nothing": NEMO as a multifunctional player in ubiquitin-mediated control of NF-kappaB activation

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12 December 2020

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

1 reference

12 December 2020

Structure, dynamics and interactions of p47, a major adaptor of the AAA ATPase, p97.

1 reference

12 December 2020

A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha

1 reference

12 December 2020

Shared principles in NF-kappaB signaling

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12 December 2020

Linear ubiquitination prevents inflammation and regulates immune signalling

1 reference

12 December 2020

The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS2068

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCOMMS2068

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10 September 2017

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