(Q39282312)

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The challenge of using read-across within the EU REACH regulatory framework; how much uncertainty is too much? Dipropylene glycol methyl ether acetate, an exemplary case study

scientific article published on 28 December 2013

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scholarly article

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Europe PubMed Central

PubMed publication ID

10 September 2017

The challenge of using read-across within the EU REACH regulatory framework; how much uncertainty is too much? Dipropylene glycol methyl ether acetate, an exemplary case study (English)

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Europe PubMed Central

PubMed publication ID

10 September 2017

Grace Patlewicz

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Grace Patlewicz

7

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Nicholas Ball

1

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Europe PubMed Central

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10 September 2017

Michael Bartels

2

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Europe PubMed Central

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10 September 2017

Robert Budinsky

3

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Europe PubMed Central

PubMed publication ID

10 September 2017

Joanna Klapacz

4

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Europe PubMed Central

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10 September 2017

Sean Hays

5

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10 September 2017

Christopher Kirman

6

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10 September 2017

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publication date

28 December 2013

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10 September 2017

Regulatory Toxicology and Pharmacology

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10 September 2017

68

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Europe PubMed Central

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10 September 2017

2

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Europe PubMed Central

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10 September 2017

212-221

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10 September 2017

Esterase activity able to hydrolyze dietary antioxidant hydroxycinnamates is distributed along the intestine of mammals.

1 reference

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Case studies to test: A framework for using structural, reactivity, metabolic and physicochemical similarity to evaluate the suitability of analogs for SAR-based toxicological assessments

1 reference

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7 January 2021

Studies on the characterization and localization of rat placental esterases

1 reference

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7 January 2021

Development of a physiologically based pharmacokinetic model for propylene glycol monomethyl ether and its acetate in rats and humans

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.12.007

7 January 2021

Hydrolysis kinetics of propylene glycol monomethyl ether acetate in rats in vivo and in rat and human tissues in vitro

1 reference

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7 January 2021

Metabolism of ethyl acetate in the rat: Hydrolysis to ethyl alcohol in vitro and in vivo

1 reference

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7 January 2021

A toxicokinetic study of inhaled ethylene glycol ethyl ether acetate and validation of a physiologically based pharmacokinetic model for rat and human.

1 reference

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7 January 2021

Prediction of human metabolic clearance from in vitro systems: retrospective analysis and prospective view

1 reference

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7 January 2021

Teratologic evaluation of inhaled propylene glycol monomethyl ether in rats and rabbits

1 reference

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7 January 2021

Proximal to distal variations in enzymes of the rat intestine

1 reference

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The role of intestinal carboxylesterase in the oral absorption of prodrugs

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The hydrolysis of flavouring esters by artificial gastrointestinal juices and rat tissue preparations

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Nature and role of xenobiotic metabolizing esterases in rat liver, lung, skin and blood.

1 reference

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7 January 2021

Comparative short-term inhalation toxicity of ethylene glycol monomethyl ether and propylene glycol monomethyl ether in rats and mice

1 reference

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7 January 2021

Comparative metabolism and disposition of ethylene glycol monomethyl ether and propylene glycol monomethyl ether in male rats

1 reference

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7 January 2021

Propylene glycol monomethyl ether acetate (PGMEA) metabolism, disposition, and short-term vapor inhalation toxicity studies

1 reference

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7 January 2021

Metabolism and disposition of dipropylene glycol monomethyl ether (DPGME) in male rats

1 reference

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7 January 2021

Nonlinear kinetics of inhaled propylene glycol monomethyl ether in Fischer 344 rats following single and repeated exposures

1 reference

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Use of category approaches, read-across and (Q)SAR: general considerations

1 reference

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7 January 2021

Workshop: use of "read-across" for chemical safety assessment under REACH.

1 reference

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7 January 2021

A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes

1 reference

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7 January 2021

The mammalian carboxylesterases: from molecules to functions

1 reference

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7 January 2021

Hydrolysis of several glycol ether acetates and acrylate esters by nasal mucosal carboxylesterase in vitro

1 reference

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7 January 2021

Use of read-across and tiered exposure assessment in risk assessment under REACH--a case study on a phase-in substance

1 reference

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7 January 2021

Acetylesterase isoenzymes in rat uterus and placenta

1 reference

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7 January 2021

A framework for using structural, reactivity, metabolic and physicochemical similarity to evaluate the suitability of analogs for SAR-based toxicological assessments.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.12.007

7 January 2021

Esterases in human saliva

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.12.007

7 January 2021

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10.1016/J.YRTPH.2013.12.007

1 reference

Europe PubMed Central

PubMed publication ID

10 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 September 2017

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