(Q84596996)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20661765%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

Prediction of human metabolic clearance from in vitro systems: retrospective analysis and prospective view (English)

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8 February 2020

1

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8 February 2020

author name string

Joanne A Foster

series ordinal

2

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8 February 2020

J Brian Houston

series ordinal

3

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8 February 2020

publication date

27 July 2010

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8 February 2020

published in

Pharmaceutical Research

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8 February 2020

volume

27

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8 February 2020

issue

10

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8 February 2020

page(s)

2150-2161

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Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: human hepatocytes, pregnane X receptor reporter gene, and Fa2N-4 and HepaRG cells

8 February 2020

cites work

1 reference

12 December 2020

A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes

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12 December 2020

The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

1 reference

12 December 2020

Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance

1 reference

12 December 2020

Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol.

1 reference

12 December 2020

Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes

1 reference

12 December 2020

Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

1 reference

12 December 2020

Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system

1 reference

12 December 2020

Physiological parameters in laboratory animals and humans

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12 December 2020

Substrate depletion approach for determining in vitro metabolic clearance: time dependencies in hepatocyte and microsomal incubations

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12 December 2020

Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance

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12 December 2020

Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo

1 reference

12 December 2020

Binding of drugs to hepatic microsomes: comment and assessment of current prediction methodology with recommendation for improvement

1 reference

12 December 2020

Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

1 reference

12 December 2020

Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes

1 reference

12 December 2020

Comparison of intrinsic clearance in liver microsomes and hepatocytes from rats and humans: evaluation of free fraction and uptake in hepatocytes.

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12 December 2020

Some suggestions for measuring predictive performance

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12 December 2020

The pivotal role of hepatocytes in drug discovery

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12 December 2020

Functional expression, inhibition and induction of CYP enzymes in HepaRG cells

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12 December 2020

Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance.

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12 December 2020

Hepatocellular binding of drugs: correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data

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12 December 2020

Human hepatocytes: isolation, cryopreservation and applications in drug development

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12 December 2020

Reliability of human cryopreserved hepatocytes and liver microsomes as in vitro systems to predict metabolic clearance

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12 December 2020

Methodological uncertainty in quantitative prediction of human hepatic clearance from in vitro experimental systems.

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12 December 2020

Kinetic determinants of hepatic clearance: plasma protein binding and hepatic uptake

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12 December 2020

Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

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12 December 2020

Simultaneous expression of plural forms of human cytochrome P450 at desired ratios in HepG2 cells: adenovirus-mediated tool for cytochrome P450 reconstitution

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12 December 2020

10.1007/S11095-010-0218-3

Identifiers

DOI

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8 February 2020

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