(Q39283279)

10 September 2017

title

Rho GTPases and cancer (English)

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10 September 2017

Hui Li

1

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10 September 2017

Karine Peyrollier

series ordinal

2

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10 September 2017

Gülcan Kilic

series ordinal

3

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10 September 2017

Cord Brakebusch

series ordinal

4

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10 September 2017

publication date

21 December 2013

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10 September 2017

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10 September 2017

volume

40

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10 September 2017

issue

2

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10 September 2017

page(s)

226-235

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Rho GTPases: biochemistry and biology

10 September 2017

cites work

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GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo

21 January 2018

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GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

21 January 2018

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Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships

21 January 2018

1 reference

Taking Rho GTPases to the next level: the cellular functions of atypical Rho GTPases

21 January 2018

1 reference

Rho GTPase regulation by miRNAs and covalent modifications

21 January 2018

1 reference

Geranylgeranylated, but not farnesylated, RhoB suppresses Ras transformation of NIH-3T3 cells

21 January 2018

1 reference

Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liver.

21 January 2018

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Rho GTPases are over-expressed in human tumors.

21 January 2018

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21 January 2018

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Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters

21 January 2018

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Expression of seven main Rho family members in gastric carcinoma

21 January 2018

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Overexpression of RhoA is associated with poor prognosis in hepatocellular carcinoma.

21 January 2018

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Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas

21 January 2018

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Differential molecular profiling between skin carcinomas reveals four newly reported genes potentially implicated in squamous cell carcinoma development

21 January 2018

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Expression and significance of RhoC gene in hepatocellular carcinoma

21 January 2018

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Expression of RHOC is associated with metastasis of gastric carcinomas

21 January 2018

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RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neck

21 January 2018

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RhoC is essential for the metastasis of gastric cancer

21 January 2018

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RhoC Promotes Metastasis via Activation of the Pyk2 Pathway in Prostate Cancer

21 January 2018

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Small G-protein RhoE is underexpressed in prostate cancer and induces cell cycle arrest and apoptosis

21 January 2018

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Overexpression of RhoE in Non-small Cell Lung Cancer (NSCLC) is associated with smoking and correlates with DNA copy number changes.

21 January 2018

1 reference

Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors

21 January 2018

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Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b

21 January 2018

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Overexpression of Rac-1 small GTPase binding protein in oral squamous cell carcinoma

21 January 2018

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Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease

21 January 2018

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Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma

21 January 2018

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Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

21 January 2018

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Prognostic implication and biological roles of RhoH in acute myeloid leukaemia

21 January 2018

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Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer

21 January 2018

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DBC2, a candidate for a tumor suppressor gene involved in breast cancer

21 January 2018

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RhoBTB2 is a substrate of the mammalian Cul3 ubiquitin ligase complex

21 January 2018

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Mutation analysis of the 8p candidate tumour suppressor genes DBC2 (RHOBTB2) and LZTS1 in bladder cancer

21 January 2018

1 reference

Coupling receptor tyrosine kinases to Rho GTPases--GEFs what's the link

21 January 2018

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Overexpressed hPTTG1 promotes breast cancer cell invasion and metastasis by regulating GEF-H1/RhoA signalling

21 January 2018

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Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy

21 January 2018

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Regulation of ROCK activity in cancer

21 January 2018

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Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells

21 January 2018

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Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

21 January 2018

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MEK mediates v-Src-induced disruption of the actin cytoskeleton via inactivation of the Rho-ROCK-LIM kinase pathway

21 January 2018

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P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis.

21 January 2018

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Morphological and proliferative abnormalities in renal mesangial cells lacking RhoGDI.

21 January 2018

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RhoGDIα-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis

21 January 2018

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The 'invisible hand': regulation of RHO GTPases by RHOGDIs

21 January 2018

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14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins

21 January 2018

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Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor

21 January 2018

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A landscape of driver mutations in melanoma

21 January 2018

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Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

21 January 2018

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Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression

21 January 2018

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RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms

21 January 2018

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β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

21 January 2018

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Rnd proteins: multifunctional regulators of the cytoskeleton and cell cycle progression.

21 January 2018

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RhoE inhibits cell cycle progression and Ras-induced transformation

21 January 2018

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RhoE is frequently down-regulated in hepatocellular carcinoma (HCC) and suppresses HCC invasion through antagonizing the Rho/Rho-kinase/myosin phosphatase target pathway.

21 January 2018

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Rnd3/RhoE Is down-regulated in hepatocellular carcinoma and controls cellular invasion

21 January 2018

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21 January 2018

RHO-GTPases and cancer

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RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis

21 January 2018

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RhoA and RhoC have distinct roles in migration and invasion by acting through different targets

21 January 2018

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Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma

21 January 2018

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Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo.

21 January 2018

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RhoA and RhoC -siRNA inhibit the proliferation and invasiveness activity of human gastric carcinoma by Rho/PI3K/Akt pathway

21 January 2018

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Characterization of the roles of RHOC and RHOA GTPases in invasion, motility, and matrix adhesion in inflammatory and aggressive breast cancers

21 January 2018

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RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes

21 January 2018

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Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1

21 January 2018

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SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin

21 January 2018

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Cdc42 promotes transendothelial migration of cancer cells through β1 integrin

21 January 2018

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Unravelling cancer stem cell potential.

21 January 2018

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KIT signaling governs differential sensitivity of mature and primitive CML progenitors to tyrosine kinase inhibitors

21 January 2018

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Stem cell depletion through epidermal deletion of Rac1.

21 January 2018

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The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface

21 January 2018

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Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin

21 January 2018

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RhoC impacts the metastatic potential and abundance of breast cancer stem cells

21 January 2018

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The small GTPase Rac1 is involved in the maintenance of stemness and malignancies in glioma stem-like cells.

21 January 2018

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Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity

21 January 2018

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Hallmarks of cancer: interactions with the tumor stroma.

21 January 2018

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Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

21 January 2018

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RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells.

21 January 2018

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RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis

21 January 2018

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The stem cell marker prominin-1/CD133 interacts with vascular endothelial growth factor and potentiates its action.

21 January 2018

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Plexin-B1 and semaphorin 4D cooperate to promote perineural invasion in a RhoA/ROK-dependent manner.

21 January 2018

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RhoH is critical for cell-microenvironment interactions in chronic lymphocytic leukemia in mice and humans

21 January 2018

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Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors

21 January 2018

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Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases

21 January 2018

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Essential role of Cdc42 in Ras-induced transformation revealed by gene targeting

21 January 2018

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Role of Rac1 in a bleomycin‐induced scleroderma model using fibroblast‐specific Rac1‐knockout mice

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIOF.1155

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10 September 2017

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