(Q39298073)

10 September 2017

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title

Glycoengineering of CHO Cells to Improve Product Quality (English)

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10 September 2017

4

Michael J Betenbaugh

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10 September 2017

Qiong Wang

1

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10 September 2017

Bojiao Yin

series ordinal

2

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10 September 2017

Cheng-Yu Chung

series ordinal

3

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10 September 2017

language of work or name

English

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publication date

1 January 2017

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Methods in Molecular Biology

10 September 2017

number of pages

20

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based on heuristic

inferred from page(s)

published in

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10 September 2017

volume

1603

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10 September 2017

page(s)

25-44

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What's fueling the biotech engine-2012 to 2013.

10 September 2017

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Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation

21 January 2018

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Optimal and consistent protein glycosylation in mammalian cell culture

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Simply better glycoproteins.

21 January 2018

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Post-translational modifications in the context of therapeutic proteins

21 January 2018

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Determination of N-glycosylation sites and site heterogeneity in glycoproteins

21 January 2018

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Quantitative mapping of glycoprotein micro-heterogeneity and macro-heterogeneity: an evaluation of mass spectrometry signal strengths using synthetic peptides and glycopeptides

21 January 2018

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N-linked protein glycosylation in the ER.

21 January 2018

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N-glycan structures: recognition and processing in the ER.

21 January 2018

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Recent advances in technology supporting biopharmaceutical production from mammalian cells

21 January 2018

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Human cells: new platform for recombinant therapeutic protein production

21 January 2018

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Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk

21 January 2018

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Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose

21 January 2018

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The choice of mammalian cell host and possibilities for glycosylation engineering.

21 January 2018

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Differences in the glycosylation of recombinant proteins expressed in HEK and CHO cells

21 January 2018

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Branched N-glycans regulate the biological functions of integrins and cadherins.

21 January 2018

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Galactosylation variations in marketed therapeutic antibodies

21 January 2018

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N-glycosylation of human interferon-gamma: glycans at Asn-25 are critical for protease resistance.

21 January 2018

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Effect of glycosylation on antibody function: implications for genetic engineering

21 January 2018

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Glycosylation of therapeutic proteins: an effective strategy to optimize efficacy

21 January 2018

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Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective.

21 January 2018

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The human sialyltransferase family

21 January 2018

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Strategies for Engineering Protein N-Glycosylation Pathways in Mammalian Cells

21 January 2018

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Carbohydrate-Specific Receptors of the Liver

21 January 2018

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Assessment of the coordinated role of ST3GAL3, ST3GAL4 and ST3GAL6 on the α2,3 sialylation linkage of mammalian glycoproteins.

21 January 2018

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Tissue plasminogen activator coexpressed in Chinese hamster ovary cells with alpha(2,6)-sialyltransferase contains NeuAc alpha(2,6)Gal beta(1,4)Glc-N-AcR linkages

21 January 2018

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A new Chinese hamster ovary cell line expressing alpha2,6-sialyltransferase used as universal host for the production of human-like sialylated recombinant glycoproteins.

21 January 2018

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Sialylation of human IgG-Fc carbohydrate by transfected rat alpha2,6-sialyltransferase.

21 January 2018

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Genetic engineering of α2,6-sialyltransferase in recombinant CHO cells and its effects on the sialylation of recombinant interferon-γ.

21 January 2018

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A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase

21 January 2018

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Regulation and pathophysiological implications of UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) as the key enzyme of sialic acid biosynthesis

21 January 2018

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Enhanced sialylation of recombinant human erythropoietin in Chinese hamster ovary cells by combinatorial engineering of selected genes.

21 January 2018

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Sialuria in a Portuguese girl: clinical, biochemical, and molecular characteristics

21 January 2018

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Clinical course and biochemistry of sialuria.

21 January 2018

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Metabolic control of recombinant protein N-glycan processing in NS0 and CHO cells

21 January 2018

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Metabolic control of recombinant monoclonal antibody N-glycosylation in GS-NS0 cells

21 January 2018

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An investigation of intracellular glycosylation activities in CHO cells: effects of nucleotide sugar precursor feeding

21 January 2018

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21 January 2018

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Enhanced sialylation of recombinant erythropoietin in genetically engineered Chinese-hamster ovary cells

21 January 2018

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Enhancing recombinant glycoprotein sialylation through CMP-sialic acid transporter over expression in Chinese hamster ovary cells

21 January 2018

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Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation

21 January 2018

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Remodeling of sugar chain structures of human interferon-gamma

21 January 2018

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Glycoengineering of Chinese hamster ovary cells for enhanced erythropoietin N-glycan branching and sialylation

21 January 2018

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Genetic engineering of CHO cells producing human interferon-gamma by transfection of sialyltransferases

21 January 2018

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RCA-I-resistant CHO mutant cells have dysfunctional GnT I and expression of normal GnT I in these mutants enhances sialylation of recombinant erythropoietin

21 January 2018

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Specificity analysis of lectins and antibodies using remodeled glycoproteins

21 January 2018

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Producing recombinant therapeutic glycoproteins with enhanced sialylation using CHO-gmt4 glycosylation mutant cells

21 January 2018

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Highly sialylated recombinant human erythropoietin production in large-scale perfusion bioreactor utilizing CHO-gmt4 (JW152) with restored GnT I function.

21 January 2018

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RNA interference of sialidase improves glycoprotein sialic acid content consistency

21 January 2018

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Characterization of cytosolic sialidase from Chinese hamster ovary cells: part I: cloning and expression of soluble sialidase in Escherichia coli

21 January 2018

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Production of recombinant human antithrombin III on 20-L bioreactor scale: correlation of supernatant neuraminidase activity, desialylation, and decrease of biological activity of recombinant glycoprotein.

21 January 2018

1 reference

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Lysosomal sialidase (neuraminidase-1) is targeted to the cell surface in a multiprotein complex that facilitates elastic fiber assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-1-4939-6972-2_2

Up-regulation of plasma membrane-associated ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-1-4939-6972-2_2

Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-1-4939-6972-2_2

Removal of sialic acid from a glycoprotein in CHO cell culture supernatant by action of an extracellular CHO cell sialidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-1-4939-6972-2_2

A comparison of the properties of a Bcl-xL variant to the wild-type anti-apoptosis inhibitor in mammalian cell cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-1-4939-6972-2_2

Structure—Function Analysis of Bcl-2 Family Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-1-4939-6972-2_2

Unknotting the roles of Bcl-2 and Bcl-xL in cell death

21 January 2018

1 reference

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Effect of Bcl-xL overexpression on sialylation of Fc-fusion protein in recombinant Chinese hamster ovary cell cultures.

21 January 2018

1 reference

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Enhancement of recombinant human EPO production and sialylation in chinese hamster ovary cells through Bombyx mori 30Kc19 gene expression

21 January 2018

1 reference

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Enhancement of recombinant human EPO production and glycosylation in serum-free suspension culture of CHO cells through expression and supplementation of 30Kc19.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-1-4939-6972-2_2

Controlling N-linked glycan site occupancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-1-4939-6972-2_2

Structural requirements of N-glycosylation of proteins. Studies with proline peptides as conformational probes

21 January 2018

1 reference

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The amino acid at the X position of an Asn-X-Ser sequon is an important determinant of N-linked core-glycosylation efficiency.

21 January 2018

1 reference

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The hydroxy amino acid in an Asn-X-Ser/Thr sequon can influence N-linked core glycosylation efficiency and the level of expression of a cell surface glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-1-4939-6972-2_2

Development and characterization of novel erythropoiesis stimulating protein (NESP)

21 January 2018

1 reference

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Darbepoetin alfa has a longer circulating half-life and greater in vivo potency than recombinant human erythropoietin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-1-4939-6972-2_2

Glycosylation of an N-terminal extension prolongs the half-life and increases the in vivo activity of follicle stimulating hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-1-4939-6972-2_2

N-glycosylation as novel strategy to improve pharmacokinetic properties of bispecific single-chain diabodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-1-4939-6972-2_2

Involvement of oligomerization, N-glycosylation and sialylation in the clearance of cholinesterases from the circulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-1-4939-6972-2_2

Hierarchy of post-translational modifications involved in the circulatory longevity of glycoproteins. Demonstration of concerted contributions of glycan sialylation and subunit assembly to the pharmacokinetic behavior of bovine acetylcholinesterase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-1-4939-6972-2_2

Modulation of therapeutic antibody effector functions by glycosylation engineering: influence of Golgi enzyme localization domain and co-expression of heterologous beta1, 4-N-acetylglucosaminyltransferase III and Golgi alpha-mannosidase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-1-4939-6972-2_2

Control of rHuEPO biological activity: the role of carbohydrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-1-4939-6972-2_2

GlycoDelete engineering of mammalian cells simplifies N-glycosylation of recombinant proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-1-4939-6972-2_2

Engineered CHO cells for production of diverse, homogeneous glycoproteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-1-4939-6972-2_2

Sequence differences between glycosylated and non-glycosylated Asn-X-Thr/Ser acceptor sites: implications for protein engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-1-4939-6972-2_2

10.1007/978-1-4939-6972-2_2

21 January 2018

Identifiers

DOI

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10 September 2017

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