(Q39312837)

10 September 2017

Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells (English)

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10 September 2017

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Cheng-Fu Zhou

1

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10 September 2017

Xue-Bing Li

2

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10 September 2017

Heng Sun

3

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10 September 2017

Bo Zhang

4

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10 September 2017

Yu-Song Han

5

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10 September 2017

Yi Jiang

6

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10 September 2017

Qiu-Lin Zhuang

7

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10 September 2017

Jing Fang

8

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10 September 2017

Guo-Hao Wu

9

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10 September 2017

18 July 2012

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10 September 2017

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10 September 2017

64

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10 September 2017

9

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10 September 2017

775-782

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Glucose avidity of carcinomas.

10 September 2017

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Human pyruvate kinase M2: a multifunctional protein

21 January 2018

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Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis?

21 January 2018

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RETRACTED: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

21 January 2018

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Cancer: Sacrifice for survival.

21 January 2018

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On the Origin of Cancer Cells

21 January 2018

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Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes

21 January 2018

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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

21 January 2018

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

21 January 2018

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The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate

21 January 2018

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Pyruvate kinase type M2 and its role in tumor growth and spreading

21 January 2018

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

21 January 2018

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Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

21 January 2018

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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein

21 January 2018

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Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7.

21 January 2018

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MUC1-C oncoprotein regulates glycolysis and pyruvate kinase M2 activity in cancer cells

21 January 2018

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Metabolic state of glioma stem cells and nontumorigenic cells

21 January 2018

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Glycolytic phenotype in breast cancer: activation of Akt, up-regulation of GLUT1, TKTL1 and down-regulation of M2PK.

21 January 2018

1 reference

21 January 2018

Cancer statistics, 2010

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Present status and perspectives of colorectal cancer in Asia: Colorectal Cancer Working Group report in 30th Asia-Pacific Cancer Conference

21 January 2018

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Toward optimized front-line therapeutic strategies in patients with metastatic colorectal cancer--an expert review from the International Congress on Anti-Cancer Treatment (ICACT) 2009.

21 January 2018

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Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity

21 January 2018

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Apigenin inhibited migration and invasion of human ovarian cancer A2780 cells through focal adhesion kinase

21 January 2018

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Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation

21 January 2018

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The metabolic marker tumour pyruvate kinase type M2 (tumour M2-PK) shows increased expression along the metaplasia-dysplasia-adenocarcinoma sequence in Barrett's oesophagus

21 January 2018

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No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

21 January 2018

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Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply

21 January 2018

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Metabolic mapping with bioluminescence: basic and clinical relevance

21 January 2018

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Breast cancer stromal myxoid changes are associated with tumor invasion and metastasis: a central role for hyaluronan

21 January 2018

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Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion

21 January 2018

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Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

21 January 2018

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Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism

21 January 2018

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Cancer's craving for sugar: an opportunity for clinical exploitation

21 January 2018

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Causes and consequences of increased glucose metabolism of cancers

21 January 2018

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Why do cancers have high aerobic glycolysis?

21 January 2018

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Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2.

21 January 2018

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Lactate stimulates endothelial cell migration.

21 January 2018

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Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis

21 January 2018

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Regulation of tumor pH and the role of carbonic anhydrase 9.

21 January 2018

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Silencing of pkm2 increases the efficacy of docetaxel in human lung cancer xenografts in mice

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IUB.1066

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10 September 2017

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