(Q39332904)

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New insights into paulomycin biosynthesis pathway in Streptomyces albus J1074 and generation of novel derivatives by combinatorial biosynthesis

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scholarly article

1 reference

Europe PubMed Central

11 September 2017

New insights into paulomycin biosynthesis pathway in Streptomyces albus J1074 and generation of novel derivatives by combinatorial biosynthesis (English)

1 reference

Europe PubMed Central

11 September 2017

Streptomyces paulus

1 reference

Streptomyces albus

1 reference

1 reference

6-O-Acetyl-1-(4-amino-3-carboxy-6-hydroxy-2,5-dioxocyclohex-3-en-1-yl)-1,5-anhydro-3-O-(2,6-dideoxy-3-O-methyl-4-C-{1-[(2-methylbutanoyl)oxy]ethyl}hexopyranosyl)hexitol

1 reference

O-Demethylpaulomycin A

1 reference

3-{4-[(5-acetyl-4,5-dihydroxy-6-methyloxan-2-yl)oxy]-6-[(acetyloxy)methyl]-3-hydroxy-5-{[(2Z)-2-isothiocyanatobut-2-enoyl]oxy}oxan-2-yl}-2,3-dihydroxy-6-imino-5-oxocyclohex-1-ene-1-carboxylic acid

1 reference

(2e)-17-(4'-Aminophenyl)-3,11,15-trihydroxy-10,12,14-trimethyl-17-oxo-heptadeca-4,6,8-trienoic acid

1 reference

3-{4-[(5-acetyl-5-hydroxy-4-methoxy-6-methyloxan-2-yl)oxy]-3-hydroxy-6-(hydroxymethyl)-5-{[(2Z)-2-isothiocyanatobut-2-enoyl]oxy}oxan-2-yl}-2,3-dihydroxy-6-imino-5-oxocyclohex-1-ene-1-carboxylic acid

1 reference

anthranilic acid

1 reference

N-acetylanthranilic acid

1 reference

(5R)-5-{6-[(acetyloxy)methyl]-3-hydroxy-4-({5-hydroxy-4-methoxy-6-methyl-5-[(1R)-1-{[(2S)-2-methylbutanoyl]oxy}ethyl]oxan-2-yl}oxy)-5-{[(2Z)-2-isothiocyanatobut-2-enoyl]oxy}oxan-2-yl}-2-amino-5-hydroxy-3,6-dioxocyclohex-1-ene-1-carboxylic acid

1 reference

5-[(3R,4S,5R,6R)-6-[(acetyloxy)methyl]-3-hydroxy-4-{[(2R,4R,5S,6R)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-5-{[(2Z)-2-isothiocyanatobut-2-enoyl]oxy}oxan-2-yl]-2-amino-5-hydroxy-3,6-dioxocyclohex-1-ene-1-carboxylic acid

1 reference

2-amino-5-[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-{[(2Z)-2-isothiocyanatobut-2-enoyl]oxy}oxan-2-yl]-5-hydroxy-3,6-dioxocyclohex-1-ene-1-carboxylic acid

1 reference

5-{4-[(5-acetyl-5-hydroxy-4-methoxy-6-methyloxan-2-yl)oxy]-6-[(acetyloxy)methyl]-3-hydroxy-5-{[(2Z)-2-isothiocyanatobut-2-enoyl]oxy}oxan-2-yl}-2-amino-5-hydroxy-3,6-dioxocyclohex-1-ene-1-carboxylic acid

1 reference

1 reference

(3S,4S)-3-[(2R,3R,4R,5S,6S)-6-(acetyloxymethyl)-3,5-dihydroxy-4-[(2R,4R,5R,6R)-5-hydroxy-4-methoxy-6-methyl-5-[(1R)-1-(2-methylpropanoyloxy)ethyl]oxan-2-yl]oxyoxan-2-yl]-2,4-dihydroxy-6-imino-5-oxocyclohexene-1-carboxylic acid

1 reference

6-O-Acetyl-1-(4-amino-3-carboxy-1-hydroxy-2,5-dioxocyclohex-3-en-1-yl)-1,5-anhydro-3-O-(2-deoxy-2-methyl-4-O-methyl-3-C-{1-[(2-methylpropanoyl)oxy]ethyl}pentopyranosyl)hexitol

1 reference

O-Demethylpaulomycin B

1 reference

1 reference

3-[(1-carboxyvinyl)oxy]benzoic acid

1 reference

1 reference

5-{6-[(acetyloxy)methyl]-3-hydroxy-4-{[5-hydroxy-5-(1-hydroxyethyl)-4-methoxy-6-methyloxan-2-yl]oxy}-5-{[(2E)-2-isothiocyanatobut-2-enoyl]oxy}oxan-2-yl}-2-amino-5-hydroxy-3,6-dioxocyclohex-1-ene-1-carboxylic acid

1 reference

Unii-BX07F07V62

1 reference

6

1 reference

Europe PubMed Central

11 September 2017

author name string

Aránzazu González

1

1 reference

Europe PubMed Central

11 September 2017

Miriam Rodríguez

2

1 reference

Europe PubMed Central

11 September 2017

Alfredo F Braña

3

1 reference

Europe PubMed Central

11 September 2017

Carmen Méndez

4

1 reference

Europe PubMed Central

11 September 2017

José A Salas

5

1 reference

Europe PubMed Central

11 September 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

21 March 2016

1 reference

Europe PubMed Central

11 September 2017

full work available at URL

https://microbialcellfactories.biomedcentral.com/track/pdf/10.1186/s12934-016-0452-4

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1186/s12934-016-0452-4?email=unpaywall_01@example.com

Microbial Cell Factories

1 reference

Europe PubMed Central

11 September 2017

15

1 reference

Europe PubMed Central

11 September 2017

1

1 reference

http://api.crossref.org/works/10.1186%2Fs12934-016-0452-4

56

1 reference

Europe PubMed Central

11 September 2017

online access status

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1186/s12934-016-0452-4?email=unpaywall_01@example.com

access restriction status

1 reference

based on heuristic

inferred from online access status

https://scigraph.springernature.com/pub.10.1186/s12934-016-0452-4

0 references

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

11 September 2017

Identification and analysis of the bacterial endosymbiont specialized for production of the chemotherapeutic natural product ET-743.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

11 September 2017

Genome Mining of Streptomyces sp. Tü 6176: Characterization of the Nataxazole Biosynthesis Pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

11 September 2017

Identification and analysis of the paulomycin biosynthetic gene cluster and titer improvement of the paulomycins in Streptomyces paulus NRRL 8115

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

11 September 2017

Strain-level diversity of secondary metabolism in Streptomyces albus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

11 September 2017

Intraspecies comparison of Streptomyces pratensis genomes reveals high levels of recombination and gene conservation between strains of disparate geographic origin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

11 September 2017

Genome based analysis of type-I polyketide synthase and nonribosomal peptide synthetase gene clusters in seven strains of five representative Nocardia species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

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Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

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Discovering new bioactive molecules from microbial sources.

1 reference

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Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

11 September 2017

Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

11 September 2017

Insights into naturally minimised Streptomyces albus J1074 genome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

11 September 2017

Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

11 September 2017

Comparative genomics of actinomycetes with a focus on natural product biosynthetic genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

11 September 2017

Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

11 September 2017

Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

11 September 2017

Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

11 September 2017

Functional analysis of OleY L-oleandrosyl 3-O-methyltransferase of the oleandomycin biosynthetic pathway in Streptomyces antibioticus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

11 September 2017

Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

11 September 2017

Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

14 September 2017

Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

14 September 2017

Glycosylated derivatives of steffimycin: insights into the role of the sugar moieties for the biological activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

14 September 2017

Evaluation of antibacterial agents in a high-volume bovine polymorphonuclear neutrophil Staphylococcus aureus intracellular killing assay

1 reference

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14 September 2017

Restriction of a bacteriophage of Streptomyces albus G involving endonuclease SalI

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

14 September 2017

Genes involved in formation and attachment of a two-carbon chain as a component of eurekanate, a branched-chain sugar moiety of avilamycin A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

25 September 2017

An efficient blue-white screening based gene inactivation system for Streptomyces

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

25 September 2017

Recently published Streptomyces genome sequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

17 June 2018

Amino acid precursor supply in the biosynthesis of the RNA polymerase inhibitor streptolydigin by Streptomyces lydicus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

17 June 2018

Activation and silencing of secondary metabolites in Streptomyces albus and Streptomyces lividans after transformation with cosmids containing the thienamycin gene cluster from Streptomyces cattleya.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

21 August 2018

Genome rearrangements of Streptomyces albus J1074 lead to the carotenoid gene cluster activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

21 August 2018

Unconventional origin and hybrid system for construction of pyrrolopyrrole moiety in kosinostatin biosynthesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

21 August 2018

Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

21 August 2018

Chapter 11. Sugar biosynthesis and modification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

21 August 2018

In situ proton NMR study of acetyl and formyl group migration in mono-O-acyl D-glucose

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

21 August 2018

Identification of transcriptional activators for thienamycin and cephamycin C biosynthetic genes within the thienamycin gene cluster from Streptomyces cattleya

1 reference

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21 August 2018

Analysis of functions in plasmid pHZ1358 influencing its genetic and structural stability in Streptomyces lividans 1326.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

21 August 2018

Acyl group migration and cleavage in selectively protected beta-d-galactopyranosides as studied by NMR spectroscopy and kinetic calculations

1 reference

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21 August 2018

Chromatographic investigation on acyl migration in betacyanins and their decarboxylated derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

21 August 2018

Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

21 August 2018

Analysis of hydrogen bonding in enzyme-substrate complexes of chloramphenicol acetyltransferase by infrared spectroscopy and site-directed mutagenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4802897

21 August 2018

A new antibiotic, U-43,120 (NSC-163500)

1 reference

https://pubmed.ncbi.nlm.nih.gov/27001601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paulomycins A and B. Isolation and characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/27001601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Precursor directed biosynthesis of paulomycins A and B. The effects of valine, isoleucine, isobutyric acid and 2-methylbutyric acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/27001601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure of paulomycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/27001601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Directed biosynthesis of paulomycin A. The effect of L-methionine, L-threonine and alpha-ketobutyric acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/27001601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paulomycin-related antibiotics: paldimycins and antibiotics 273a2. Isolation and characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/27001601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paldimycins A and B and antibiotics 273a2 alpha and 273a2 beta. Synthesis and characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/27001601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro evaluation of the new paulomycin antibiotic paldimycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/27001601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New paulomycins produced by Streptomyces paulus

1 reference

https://pubmed.ncbi.nlm.nih.gov/27001601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Precursor directed biosynthesis of paulomycin C by methionine

1 reference

https://pubmed.ncbi.nlm.nih.gov/27001601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Streptomyces albus G produces an antibiotic complex identical to paulomycins A and B

1 reference

https://pubmed.ncbi.nlm.nih.gov/27001601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of antibiotic effectiveness against Staphylococcus aureus surviving within the bovine mammary gland macrophage

1 reference

https://pubmed.ncbi.nlm.nih.gov/27001601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural relationships between senfolomycins and paulomycins

1 reference

https://pubmed.ncbi.nlm.nih.gov/27001601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O-demethylpaulomycins A and B, U-77,802 and U-77,803, paulomenols A and B, new metabolites produced by Streptomyces paulus

1 reference

https://pubmed.ncbi.nlm.nih.gov/27001601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thuggacins, Macrolide Antibiotics Active againstMycobacterium tuberculosis: Isolation from Myxobacteria, Structure Elucidation, Conformation Analysis and Biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27001601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of Two Genes from Streptomyces argillaceus Encoding Glycosyltransferases Involved in Transfer of a Disaccharide during Biosynthesis of the Antitumor Drug Mithramycin

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1128/JB.180.18.4929-4937.1998

Identifiers

10.1186/S12934-016-0452-4

1 reference

Europe PubMed Central

11 September 2017

Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/s12934-016-0452-4

1 reference

Europe PubMed Central

11 September 2017

1 reference

Europe PubMed Central

11 September 2017

ResearchGate publication ID

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