(Q33804081)

29 July 2017

title

Microbial genome mining for accelerated natural products discovery: is a renaissance in the making? (English)

1 reference

29 July 2017

1 reference

1

Brian O Bachmann

1 reference

29 July 2017

Steven G Van Lanen

2

1 reference

29 July 2017

Richard H Baltz

series ordinal

3

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29 July 2017

publication date

17 December 2013

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Journal of Industrial Microbiology & Biotechnology

29 July 2017

published in

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29 July 2017

volume

41

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29 July 2017

issue

2

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29 July 2017

page(s)

175-184

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Activating secondary metabolism with stress and chemicals

29 July 2017

cites work

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4 July 2018

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4 July 2018

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4 July 2018

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Importance of microbial natural products and the need to revitalize their discovery

4 July 2018

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4 July 2018

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Triggers and cues that activate antibiotic production by actinomycetes

4 July 2018

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Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products

4 July 2018

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4 July 2018

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Combinatorial biosynthesis of cyclic lipopeptide antibiotics: a model for synthetic biology to accelerate the evolution of secondary metabolite biosynthetic pathways

4 July 2018

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Achieving cancer cell death with PI3K/mTOR-targeted therapies

4 July 2018

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Mutasynthesis of fluorinated pactamycin analogues and their antimalarial activity

4 July 2018

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Development of PI3K inhibitors: lessons learned from early clinical trials

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Structural Basis of the Interaction of MbtH-like Proteins, Putative Regulators of Nonribosomal Peptide Biosynthesis, with Adenylating Enzymes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Interkingdom metabolic transformations captured by microbial imaging mass spectrometry

4 July 2018

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Transforming clinical microbiology with bacterial genome sequencing.

4 July 2018

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Merochlorins A-D, cyclic meroterpenoid antibiotics biosynthesized in divergent pathways with vanadium-dependent chloroperoxidases

4 July 2018

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Microbial strain prioritization using metabolomics tools for the discovery of natural products.

4 July 2018

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Refactoring the nitrogen fixation gene cluster from Klebsiella oxytoca

4 July 2018

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Biocatalysts and small molecule products from metagenomic studies

4 July 2018

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Analyses of MbtB, MbtE, and MbtF suggest revisions to the mycobactin biosynthesis pathway in Mycobacterium tuberculosis

4 July 2018

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Natural product biosynthetic gene diversity in geographically distinct soil microbiomes.

4 July 2018

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Combinatorial biosynthesis of polyketides—a perspective

4 July 2018

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Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

4 July 2018

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Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Biosynthesis of the Apoptolidins in Nocardiopsis sp. FU 40.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Complete genome sequence of Streptosporangium roseum type strain (NI 9100).

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Complete genome sequence of Actinosynnema mirum type strain (101).

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Strain improvement in actinomycetes in the postgenomic era.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Current approaches to exploit actinomycetes as a source of novel natural products.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Microscale methodology for structure elucidation of natural products

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Myxobacterial secondary metabolites: bioactivities and modes-of-action.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

NMR of natural products at the 'nanomole-scale'.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Genomic basis for natural product biosynthetic diversity in the actinomycetes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

New natural product biosynthetic chemistry discovered by genome mining

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Strategies for the discovery of new natural products by genome mining

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Renaissance in antibacterial discovery from actinomycetes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Molecular engineering approaches to peptide, polyketide and other antibiotics

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

4 July 2018

1 reference

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Structural genomics of human proteins--target selection and generation of a public catalogue of expression clones

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Marine actinomycete diversity and natural product discovery.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Preparing protein microarrays by soft-landing of mass-selected ions

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

Genomics and the ancient origins of the daptomycin biosynthetic gene cluster

4 July 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1389-9

Coelichelin, a new peptide siderophore encoded by the Streptomyces coelicolor genome: structure prediction from the sequence of its non-ribosomal peptide synthetase

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10295-013-1389-9

The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1389-9

Efficient mining of myxobacterial metabolite profiles enabled by liquid chromatography-electrospray ionisation-time-of-flight mass spectrometry and compound-based principal component analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1389-9

Discovery of a new peptide natural product by Streptomyces coelicolor genome mining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1389-9

Biosynthetic studies and genetic engineering of pactamycin analogs with improved selectivity toward malarial parasites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1389-9

Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1389-9

A genomics-guided approach for discovering and expressing cryptic metabolic pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1389-9

MbtH homology codes to identify gifted microbes for genome mining

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4070288

10.1007/S10295-013-1389-9

30 October 2018

Identifiers

DOI

1 reference

29 July 2017

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29 July 2017

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