(Q37751993)

22 August 2017

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title

Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters (English)

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22 August 2017

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Richard H Baltz

1

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22 August 2017

14 May 2010

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Journal of Industrial Microbiology & Biotechnology

22 August 2017

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22 August 2017

37

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22 August 2017

759-772

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22 August 2017

8

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Genetic recombination in Streptomyces fradiae by protoplast fusion and cell regeneration

22 August 2017

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https://api.crossref.org/works/10.1007%2FS10295-010-0730-9

Properties of Streptomyces fradiae Mutants Blocked in Biosynthesis of the Macrolide Antibiotic Tylosin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-010-0730-9

Cloning and heterologous expression of the entire set of structural genes for nikkomycin synthesis from Streptomyces tendae Tü901 in Streptomyces lividans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-010-0730-9

Tn5099, a xylE promoter probe transposon for Streptomyces spp

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-010-0730-9

Use of rpsL for dominance selection and gene replacement in Streptomyces roseosporus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-010-0730-9

Site-specific integration in Streptomyces ambofaciens: localization of integration functions in S. ambofaciens plasmid pSAM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-010-0730-9

Hypervariability, a new phenomenon of genetic instability, related to DNA amplification in Streptomyces ambofaciens

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10295-010-0730-9

Genetic instability and associated genome plasticity in Streptomyces ambofaciens: pulsed-field gel electrophoresis evidence for large DNA alterations in a limited genomic region

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10295-010-0730-9

Transduction and transformation of plasmid DNA in Streptomyces fradiae strains that express different levels of restriction

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10295-010-0730-9

Intergeneric conjugation between Escherichia coli and Streptomyces species

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10295-010-0730-9

Transduction of plasmid DNA in Streptomyces spp. and related genera by bacteriophage FP43

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10295-010-0730-9

Transposition of Tn5096 from a temperature-sensitive transducible plasmid in Streptomyces spp

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-010-0730-9

Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-010-0730-9

Cloning of spiramycin biosynthetic genes and their use in constructing Streptomyces ambofaciens mutants defective in spiramycin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-010-0730-9

S-Adenosyl-L-methionine: macrocin O-methyltransferase activities in a series of Streptomyces fradiae mutants that produce different levels of the macrolide antibiotic tylosin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-010-0730-9

Transposition of Tn5096 and other IS493 derivatives in Streptomyces griseofuscus

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10295-010-0730-9

Biosynthetic studies on antibiotic A47934.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10295-010-0730-9

Efficient plasmid transformation of Streptomyces ambofaciens and Streptomyces fradiae protoplasts

21 January 2018

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12 December 2020

Engineered biosynthesis of a complete macrolactone in a heterologous host

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12 December 2020

Microbial genomics for the improvement of natural product discovery

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12 December 2020

Spiramycin renaissance

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12 December 2020

Production of 8'-halogenated and 8'-unsubstituted novobiocin derivatives in genetically engineered streptomyces coelicolor strains.

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12 December 2020

Development of a genetic system for combinatorial biosynthesis of lipopeptides in Streptomyces fradiae and heterologous expression of the A54145 biosynthesis gene cluster

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12 December 2020

Genomic mining--a concept for the discovery of new bioactive natural products

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12 December 2020

An amplifiable and deletable locus of Streptomyces ambofaciens RP181110 contains a very large gene homologous to polyketide synthase genes

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12 December 2020

Regulation of secondary metabolism in streptomycetes

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12 December 2020

Genomic basis for natural product biosynthetic diversity in the actinomycetes

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12 December 2020

Production of a hybrid macrolide antibiotic in Streptomyces ambofaciens and Streptomyces lividans by introduction of a cloned carbomycin biosynthetic gene from Streptomyces thermotolerans

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12 December 2020

Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

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12 December 2020

Inactivation of a transcriptional repressor during empirical improvement of the tylosin producer, Streptomyces fradiae

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12 December 2020

Glycosylated derivatives of steffimycin: insights into the role of the sugar moieties for the biological activity

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12 December 2020

Large genomic rearrangements of the unstable region in Streptomyces ambofaciens are associated with major changes in global gene expression

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12 December 2020

Genetic instability and hypervariability in Streptomyces ambofaciens: towards an understanding of a mechanism of genome plasticity.

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12 December 2020

The use of recombinant DNA techniques to study tylosin biosynthesis and resistance in Streptomyces fradiae

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12 December 2020

Gene transfer and transposition mutagenesis in Streptomyces roseosporus: mapping of insertions that influence daptomycin or pigment production

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12 December 2020

Identification of the biosynthetic gene cluster and an additional gene for resistance to the antituberculosis drug capreomycin

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12 December 2020

Restriction of bacteriophage plaque formation in Streptomyces spp

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12 December 2020

Plasmid cloning vectors that integrate site-specifically in Streptomyces spp.

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12 December 2020

Cloning and nucleotide sequence of a carbomycin-resistance gene from Streptomyces thermotolerans.

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12 December 2020

Chapter 5 Applying the Genetics of Secondary Metabolism in Model Actinomycetes to the Discovery of New Antibiotics

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12 December 2020

Highly transformable mutants of Streptomyces fradiae defective in several restriction systems

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12 December 2020

Cloning of the complete biosynthetic gene cluster for an aminonucleoside antibiotic, puromycin, and its regulated expression in heterologous hosts

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12 December 2020

Involvement of AlpV, a new member of the Streptomyces antibiotic regulatory protein family, in regulation of the duplicated type II polyketide synthase alp gene cluster in Streptomyces ambofaciens.

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12 December 2020

End-to-end fusion of linear deleted chromosomes initiates a cycle of genome instability in Streptomyces ambofaciens

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12 December 2020

Analysis of the integration function of the streptomycete bacteriophage φC31

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12 December 2020

Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae

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12 December 2020

Protoplast fusion in Streptomyces: conditions for efficient genetic recombination and cell regeneration

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12 December 2020

Genetics of Streptomyces fradiae and tylosin biosynthesis

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12 December 2020

A gene cluster for biosynthesis of the sesquiterpenoid antibiotic pentalenolactone in Streptomyces avermitilis

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12 December 2020

Molecular cloning and physical mapping of the daptomycin gene cluster from Streptomyces roseosporus

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12 December 2020

DNA processing reactions in bacterial conjugation

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12 December 2020

A54145, a new lipopeptide antibiotic complex: discovery, taxonomy, fermentation and HPLC.

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12 December 2020

Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis

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12 December 2020

Complementation of daptomycin dptA and dptD deletion mutations in trans and production of hybrid lipopeptide antibiotics

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12 December 2020

Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350

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12 December 2020

Strategies to unravel the function of orphan biosynthesis pathways: recent examples and future prospects

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12 December 2020

Cloning and heterologous expression in Streptomyces lividans of Streptomyces rimosus genes involved in oxytetracycline biosynthesis

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12 December 2020

Biosynthesis and genetic engineering of lipopeptide antibiotics related to daptomycin

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12 December 2020

Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

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12 December 2020

Genetics and biochemistry on tylosin production: a model for genetic engineering in antibiotic-producing Streptomyces

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12 December 2020

Cloning and heterologous expression of the macrotetrolide biosynthetic gene cluster revealed a novel polyketide synthase that lacks an acyl carrier protein

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12 December 2020

ClustScan: an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures

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12 December 2020

Mining microbial genomes for new natural products and biosynthetic pathways

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12 December 2020

The lipopeptide antibiotic A54145 biosynthetic gene cluster from Streptomyces fradiae

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12 December 2020

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

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12 December 2020

Hypertransposing derivatives of the streptomycete insertion sequence IS493.

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12 December 2020

An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus

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12 December 2020

Genome mining in Streptomyces avermitilis: A biochemical Baeyer-Villiger reaction and discovery of a new branch of the pentalenolactone family tree

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12 December 2020

High frequency conjugal transfer of tylosin genes and amplifiable DNA in Streptomyces fradiae

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12 December 2020

Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol

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12 December 2020

Shuttle vectors for cloning recombinant DNA in Escherichia coli and Streptomyces griseofuscus C581

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12 December 2020

Engineered production of iso-migrastatin in heterologous Streptomyces hosts

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12 December 2020

Identification and utility of FdmR1 as a Streptomyces antibiotic regulatory protein activator for fredericamycin production in Streptomyces griseus ATCC 49344 and heterologous hosts

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12 December 2020

Heterologous production of daptomycin in Streptomyces lividans.

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12 December 2020

Recent advances in the biochemistry of spinosyns

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12 December 2020

Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis

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12 December 2020

A glutamic acid 3-methyltransferase encoded by an accessory gene locus important for daptomycin biosynthesis in Streptomyces roseosporus

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12 December 2020

Reducing the variability of antibiotic production in Streptomyces by cultivation in 24-square deepwell plates

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12 December 2020

Selection of Streptomyces ambofaciens mutants that produce large quantities of spiramycin and determination of optimal conditions for spiramycin production

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12 December 2020

A47934, a novel glycopeptide-aglycone antibiotic produced by a strain of Streptomyces toyocaensis taxonomy and fermentation studies.

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12 December 2020

Control of tylosin biosynthesis in Streptomyces fradiae.

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12 December 2020

Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.

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12 December 2020

Investigations into viomycin biosynthesis by using heterologous production in Streptomyces lividans

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12 December 2020

Chapter 8. Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence data

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12 December 2020

Conjugal transfer of cosmid DNA from Escherichia coli to Saccharopolyspora spinosa: effects of chromosomal insertions on macrolide A83543 production

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12 December 2020

From microbial differentiation to ribosome engineering

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12 December 2020

Production of hybrid 16-membered macrolides by expressing combinations of polyketide synthase genes in engineered Streptomyces fradiae hosts

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12 December 2020

Macrolide antibiotics in food-animal health

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12 December 2020

Molecular engineering approaches to peptide, polyketide and other antibiotics

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12 December 2020

DNA rearrangements at the extremities of the Streptomyces ambofaciens linear chromosome: evidence for developmental control

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12 December 2020

Chapter 20. Biosynthesis and genetic engineering of lipopeptides in Streptomyces roseosporus

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12 December 2020

Automated genome mining for natural products.

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12 December 2020

A gene cloning system for 'Streptomyces toyocaensis'

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12 December 2020

Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two streptomyces species

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12 December 2020

Comparative genomic hybridizations reveal absence of large Streptomyces coelicolor genomic islands in Streptomyces lividans

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12 December 2020

Rapid engineering of polyketide overproduction by gene transfer to industrially optimized strains

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12 December 2020

Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin

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12 December 2020

Production of a novel polyketide through the construction of a hybrid polyketide synthase.

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12 December 2020

Production of hybrid glycopeptide antibiotics in vitro and in Streptomyces toyocaensis

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12 December 2020

The minimal replicon of a streptomycete plasmid produces an ultrahigh level of plasmid DNA.

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12 December 2020

A new shuttle cosmid vector, pKC505, for streptomycetes: its use in the cloning of three different spiramycin-resistance genes from a Streptomyces ambofaciens library

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12 December 2020

Renaissance in antibacterial discovery from actinomycetes

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12 December 2020

Marcel Faber Roundtable: is our antibiotic pipeline unproductive because of starvation, constipation or lack of inspiration?

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12 December 2020

Activation of dormant bacterial genes by Nonomuraea sp. strain ATCC 39727 mutant-type RNA polymerase

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12 December 2020

Cloning and expression of a tylosin resistance gene from a tylosin-producing strain of Streptomyces fradiae

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12 December 2020

Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.

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12 December 2020

Genetic engineering in Streptomyces roseosporus to produce hybrid lipopeptide antibiotics

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12 December 2020

Antibiotic overproduction by rpsL and rsmG mutants of various actinomycetes

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12 December 2020

Streptomyces antibioticus contains at least three oleandomycin-resistance determinants, one of which shows similarity with proteins of the ABC-transporter superfamily.

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12 December 2020

Chapter 4. Analyzing the regulation of antibiotic production in streptomycetes

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12 December 2020

Combinatorial biosynthesis of novel antibiotics related to daptomycin

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12 December 2020

Bioinformatic perspectives on NRPS/PKS megasynthases: advances and challenges

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12 December 2020

Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus

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12 December 2020

Evolution of the terminal regions of the Streptomyces linear chromosome

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12 December 2020

Daptomycin biosynthesis in Streptomyces roseosporus: cloning and analysis of the gene cluster and revision of peptide stereochemistry

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12 December 2020

Conjugal transfer using the bacteriophage phiC31 att/int system and properties of the attB site in Streptomyces ambofaciens

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12 December 2020

CLUSEAN: a computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters.

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12 December 2020

Daptomycin: from the mountain to the clinic, with essential help from Francis Tally, MD.

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12 December 2020

Genetically engineered lipopeptide antibiotics related to A54145 and daptomycin with improved properties

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12 December 2020

Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster

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12 December 2020

New natural product biosynthetic chemistry discovered by genome mining

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12 December 2020

Heterologous expression of novobiocin and clorobiocin biosynthetic gene clusters

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12 December 2020

Restriction of a bacteriophage of Streptomyces albus G involving endonuclease SalI

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12 December 2020

10.1007/S10295-010-0730-9

Identifiers

DOI

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22 August 2017

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PubMed ID

20467781