(Q34589692)

3 August 2017

1 reference

title

Molecular engineering approaches to peptide, polyketide and other antibiotics (English)

1 reference

3 August 2017

0 references

Richard H Baltz

1

1 reference

3 August 2017

publication date

1 December 2006

1 reference

3 August 2017

1 reference

3 August 2017

volume

24

1 reference

3 August 2017

issue

12

1 reference

3 August 2017

page(s)

1533-1540

1 reference

https://scigraph.springernature.com/pub.10.1038/nbt1265

3 August 2017

exact match

0 references

cites work

New aminocoumarin antibiotics from genetically engineered Streptomyces strains.

1 reference

Natural products as sources of new drugs over the period 1981-2002.

21 January 2018

1 reference

7 January 2021

New advances in antibiotic development and discovery

1 reference

7 January 2021

Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits

1 reference

7 January 2021

Manipulation of Modular Polyketide Synthases.

1 reference

7 January 2021

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

1 reference

7 January 2021

Lambda red-mediated genetic manipulation of antibiotic-producing Streptomyces.

1 reference

7 January 2021

Rapid engineering of the geldanamycin biosynthesis pathway by Red/ET recombination and gene complementation

1 reference

7 January 2021

Natural products to drugs: daptomycin and related lipopeptide antibiotics

1 reference

7 January 2021

Combinatorial biosynthesis of lipopeptide antibiotics in Streptomyces roseosporus

1 reference

7 January 2021

Genetic manipulation of antibiotic-producing Streptomyces

1 reference

7 January 2021

Engineering biosynthetic pathways to generate antitumor indolocarbazole derivatives

1 reference

7 January 2021

Production of 8'-halogenated and 8'-unsubstituted novobiocin derivatives in genetically engineered streptomyces coelicolor strains.

1 reference

7 January 2021

Heterologous production of daptomycin in Streptomyces lividans.

1 reference

7 January 2021

Production of hybrid glycopeptide antibiotics in vitro and in Streptomyces toyocaensis

1 reference

7 January 2021

Production of hybrid 16-membered macrolides by expressing combinations of polyketide synthase genes in engineered Streptomyces fradiae hosts

1 reference

7 January 2021

Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

1 reference

7 January 2021

Genetic engineering in Streptomyces roseosporus to produce hybrid lipopeptide antibiotics

1 reference

7 January 2021

Substrate recognition by nonribosomal peptide synthetase multi-enzymes

1 reference

7 January 2021

Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics.

1 reference

7 January 2021

Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides

1 reference

7 January 2021

Selective interaction between nonribosomal peptide synthetases is facilitated by short communication-mediating domains

1 reference

7 January 2021

Harnessing the potential of communication-mediating domains for the biocombinatorial synthesis of nonribosomal peptides

1 reference

7 January 2021

Glycopeptides: Update on an old successful antibiotic class

1 reference

7 January 2021

A systematic investigation of the synthetic utility of glycopeptide glycosyltransferases

1 reference

7 January 2021

Glycopeptide and lipoglycopeptide antibiotics

1 reference

7 January 2021

Comparative analysis and insights into the evolution of gene clusters for glycopeptide antibiotic biosynthesis.

1 reference

7 January 2021

Biosynthesis of chloro-beta-hydroxytyrosine, a nonproteinogenic amino acid of the peptidic backbone of glycopeptide antibiotics.

1 reference

7 January 2021

The biosynthesis of glycopeptide antibiotics?a model for complex, non-ribosomally synthesized, peptidic secondary metabolites

1 reference

7 January 2021

The biosynthesis of vancomycin-type glycopeptide antibiotics--a model for oxidative side-chain cross-linking by oxygenases coupled to the action of peptide synthetases

1 reference

7 January 2021

Antibiotic glycosyltransferases: antibiotic maturation and prospects for reprogramming

1 reference

7 January 2021

Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides

1 reference

7 January 2021

Structure-based engineering of E. coli galactokinase as a first step toward in vivo glycorandomization

1 reference

7 January 2021

Neoglycorandomization and chemoenzymatic glycorandomization: two complementary tools for natural product diversification

1 reference

7 January 2021

Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions

1 reference

7 January 2021

Tailoring of glycopeptide scaffolds by the acyltransferases from the teicoplanin and A-40,926 biosynthetic operons

1 reference

7 January 2021

Bromobalhimycin and chlorobromobalhimycins--illuminating the potential of halogenases in glycopeptide antibiotic biosyntheses

1 reference

7 January 2021

Fluorobalhimycin--a new chapter in glycopeptide antibiotic research

1 reference

7 January 2021

Mutasynthesis of glycopeptide antibiotics: variations of vancomycin's AB-ring amino acid 3,5-dihydroxyphenylglycine

1 reference

7 January 2021

Combinatorial biosynthesis of novel antibiotics related to daptomycin

1 reference

7 January 2021

Complementation of daptomycin dptA and dptD deletion mutations in trans and production of hybrid lipopeptide antibiotics

1 reference

7 January 2021

A glutamic acid 3-methyltransferase encoded by an accessory gene locus important for daptomycin biosynthesis in Streptomyces roseosporus

1 reference

7 January 2021

Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor.

1 reference

7 January 2021

The lipopeptide antibiotic A54145 biosynthetic gene cluster from Streptomyces fradiae

1 reference

7 January 2021

Synthesis and derivatization of daptomycin: a chemoenzymatic route to acidic lipopeptide antibiotics

1 reference

7 January 2021

Chemoenzymatic design of acidic lipopeptide hybrids: new insights into the structure-activity relationship of daptomycin and A54145.

1 reference

7 January 2021

Genetic approaches to polyketide antibiotics. 1.

1 reference

7 January 2021

Combinatorial biosynthesis of reduced polyketides

1 reference

7 January 2021

A model of structure and catalysis for ketoreductase domains in modular polyketide synthases

1 reference

7 January 2021

Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase.

1 reference

7 January 2021

High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase.

1 reference

7 January 2021

Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.

1 reference

7 January 2021

Activating hybrid modular interfaces in synthetic polyketide synthases by cassette replacement of ketosynthase domains

1 reference

7 January 2021

The Lego-ization of polyketide biosynthesis.

1 reference

7 January 2021

Redesign, synthesis and functional expression of the 6-deoxyerythronolide B polyketide synthase gene cluster.

1 reference

7 January 2021

Production of the potent antibacterial polyketide erythromycin C in Escherichia coli

1 reference

7 January 2021

Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: opportunities, limitations, and mechanistic hypotheses

1 reference

7 January 2021

In vitro and in vivo production of new aminocoumarins by a combined biochemical, genetic, and synthetic approach

1 reference

7 January 2021

Heterologous expression of novobiocin and clorobiocin biosynthetic gene clusters

1 reference

7 January 2021

Structure-activity relationships of aminocoumarin-type gyrase and topoisomerase IV inhibitors obtained by combinatorial biosynthesis

1 reference

7 January 2021

Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa

1 reference

7 January 2021

Butenyl-spinosyns, a natural example of genetic engineering of antibiotic biosynthetic genes

1 reference

7 January 2021

Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase

1 reference

7 January 2021

Combinatorial biosynthesis of antitumor indolocarbazole compounds

1 reference

7 January 2021

Understanding and manipulating glycopeptide pathways: the example of the dalbavancin precursor A40926.

1 reference

7 January 2021

Identifiers

DOI

10.1038/NBT1265

1 reference

3 August 2017

1 reference