(Q31128037)

29 June 2017

title

Importance of microbial natural products and the need to revitalize their discovery (English)

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29 June 2017

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Arnold L Demain

1

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29 June 2017

publication date

30 August 2013

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Journal of Industrial Microbiology & Biotechnology

29 June 2017

published in

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29 June 2017

volume

41

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29 June 2017

issue

2

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29 June 2017

page(s)

185-201

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Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent

29 June 2017

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Bioreactor studies on the endophytic fungus Entrophospora infrequens for the production of an anticancer alkaloid camptothecin.

21 January 2018

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Lantibiotics: diverse activities and unique modes of action

21 January 2018

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Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.

21 January 2018

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Bartolomeo Gosio, 1863-1944: an appreciation.

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12 December 2020

Investing in green and white biotech.

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Studies in the biochemistry of micro-organisms. 86. The molecular constitution of mycophenolic acid, a metabolic product of Penicillium Brevi-compactum Dierckx. Part III. Further observations on the structural formula for mycophenolic acid

21 January 2018

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Big effects from small changes: possible ways to explore nature's chemical diversity.

21 January 2018

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Fungal secondary metabolites - strategies to activate silent gene clusters

21 January 2018

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Natural product guided compound library development

21 January 2018

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Quinolone, everninomycin, glycylcycline, carbapenem, lipopeptide and cephem antibacterials in clinical development

21 January 2018

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Crystal and molecular structure of compactin, a new antifungal metabolite from Penicillium brevicompactum

21 January 2018

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21 January 2018

12 December 2020

Search and discovery strategies for biotechnology: the paradigm shift

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Antibiotic-producing ability by representatives of a newly discovered lineage of actinomycetes.

21 January 2018

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History of avermectin and ivermectin, with notes on the history of other macrocyclic lactone antiparasitic agents

21 January 2018

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A review of Judah Folkman's remarkable achievements in biomedicine

21 January 2018

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The TOR signaling cascade regulates gene expression in response to nutrients

21 January 2018

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Ascomycins: promising agents for the treatment of inflammatory skin diseases

21 January 2018

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Antineoplastic agents from natural sources: achievements and future directions

21 January 2018

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Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin

21 January 2018

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Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR

21 January 2018

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Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiae

21 January 2018

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From natural products discovery to commercialization: a success story

21 January 2018

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Contributions of microorganisms to industrial biology

21 January 2018

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Back to basics: how natural products can provide the basis for new therapeutics

21 January 2018

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Characterization of protein Ser/Thr phosphatases of the malaria parasite, Plasmodium falciparum: inhibition of the parasitic calcineurin by cyclophilin-cyclosporin complex

21 January 2018

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Biomedicinals from the phytosymbionts of marine invertebrates: a molecular approach

21 January 2018

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A new class of cyclosporin analogues for the treatment of asthma

21 January 2018

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Curing metastatic testicular cancer

21 January 2018

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A historical perspective on the discovery of statins

21 January 2018

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Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity

21 January 2018

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Cancer risk in people infected with human immunodeficiency virus in the United States

21 January 2018

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Nonribosomal peptide synthetases involved in the production of medically relevant natural products

21 January 2018

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Update on antifungals targeted to the cell wall: focus on beta-1,3-glucan synthase inhibitors

21 January 2018

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Neuroimmunophilin ligands: evaluation of their therapeutic potential for the treatment of neurological disorders

21 January 2018

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Novel cytotoxic agents: epothilones

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Chasing the treasures of the sea - bacterial marine natural products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies

21 January 2018

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Plasticity of the streptomyces genome-evolution and engineering of new antibiotics

21 January 2018

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Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis

21 January 2018

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Marine actinomycete diversity and natural product discovery.

21 January 2018

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Taxol from Phyllosticta citricarpa, a leaf spot fungus of the angiosperm Citrus medica

21 January 2018

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Shikonin, acetylshikonin, and isobutyroylshikonin inhibit VEGF-induced angiogenesis and suppress tumor growth in lewis lung carcinoma-bearing mice.

21 January 2018

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Camptothecin, over four decades of surprising findings

21 January 2018

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Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs.

21 January 2018

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Natural products as sources of new drugs over the period 1981-2002.

21 January 2018

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Ivermectin: 25 years and still going strong

21 January 2018

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Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei

21 January 2018

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Antibiotics: where did we go wrong?

21 January 2018

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Genetic engineering of macrolide biosynthesis: past advances, current state, and future prospects

21 January 2018

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Biosynthesis of rapamycin and its regulation: past achievements and recent progress

21 January 2018

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2002 Alfred Burger Award Address in Medicinal Chemistry. Natural products and design: interrelated approaches in drug discovery

21 January 2018

1 reference

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Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei

21 January 2018

1 reference

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Diazo transfer-click reaction route to new, lipophilic teicoplanin and ristocetin aglycon derivatives with high antibacterial and anti-influenza virus activity: an aggregation and receptor binding study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Plants and human health in the twenty-first century.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Genetically engineered analogs of ascomycin for nerve regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Multidrug resistance reversal agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

The TOR kinases link nutrient sensing to cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Systems biology of antibiotic production by microorganisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Antimicrobials, drug discovery, and genome mining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Therapeutic potential of type A (I) lantibiotics, a group of cationic peptide antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

What's new on the antimicrobial horizon?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Rainforest endophytes and bioactive products

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Statins: the new aspirin?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Camptothecin and taxol: from discovery to clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Taxol from Tubercularia sp. strain TF5, an endophytic fungus of Taxus mairei

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Mining and engineering natural-product biosynthetic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Combinatorial biosynthesis of polyketides--a perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Efficient synthesis of simvastatin by use of whole-cell biocatalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Improving simvastatin bioconversion in Escherichia coli by deletion of bioH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

A multiplasmid approach to preparing large libraries of polyketides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Natural product-based anti-HIV drug discovery and development facilitated by the NCI developmental therapeutics program

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Antibiotic resistance in bacteria and its future for novel antibiotic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

A genomics-guided approach for discovering and expressing cryptic metabolic pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

Production of ‘hybrid’ antibiotics by genetic engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-013-1325-Z

A two component-type cytochrome P-450 monooxygenase system in a prokaryote that catalyzes hydroxylation of ML-236B to pravastatin, a tissue-selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase

21 January 2018

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12 December 2020

Genomic mining for Aspergillus natural products

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12 December 2020

Combinatorial biosynthesis of cyclic lipopeptide antibiotics: a model for synthetic biology to accelerate the evolution of secondary metabolite biosynthetic pathways

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12 December 2020

Prodigiosins: a novel family of immunosuppressants with anti-cancer activity

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12 December 2020

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells

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12 December 2020

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12 December 2020

A guide to drug discovery: Target selection in drug discovery

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12 December 2020

Production and Purification of Statins from Pleurotus ostreatus (Basidiomycetes) Strains

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12 December 2020

Prescription for an ailing pharmaceutical industry

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12 December 2020

Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase

1 reference

12 December 2020

From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries

1 reference

12 December 2020

Cineromycins, gamma-butyrolactones and ansamycins by analysis of the secondary metabolite pattern created by a single strain of Streptomyces

1 reference

12 December 2020

Studies on the biosynthesis of epothilones: the biosynthetic origin of the carbon skeleton

1 reference

12 December 2020

Antibiotics at the crossroads

1 reference

12 December 2020

Mother nature's combinatorial libraries; their influence on the synthesis of drugs.

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12 December 2020

HMG-CoA reductase inhibitors for lowering elevated levels of C-reactive protein.

1 reference

12 December 2020

Antibiotics--an investment worth making?

1 reference

12 December 2020

10.1007/S10295-013-1325-Z

Identifiers

DOI

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29 June 2017

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