(Q33288081)

25 July 2017

1 reference

title

Mining and engineering natural-product biosynthetic pathways (English)

1 reference

25 July 2017

1 reference

Barrie Wilkinson

1

1 reference

25 July 2017

Jason Micklefield

series ordinal

2

1 reference

25 July 2017

language of work or name

1 reference

1 July 2007

1 reference

25 July 2017

published in

Nature Chemical Biology

1 reference

25 July 2017

volume

3

1 reference

25 July 2017

issue

7

1 reference

25 July 2017

page(s)

379-386

1 reference

Active-site residue, domain and module swaps in modular polyketide synthases

25 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

New aminocoumarin antibiotics from genetically engineered Streptomyces strains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

Natural products as sources of new drugs over the period 1981-2002.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Chemical genetics to chemical genomics: small molecules offer big insights

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

The evolving role of natural products in drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Biocatalysis in pharmaceutical preparation and alteration

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Production of the antimalarial drug precursor artemisinic acid in engineered yeast

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Genome sequencing in microfabricated high-density picolitre reactors

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

A streamlined metabolic pathway for the biosynthesis of moenomycin A.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Discovery of a new peptide natural product by Streptomyces coelicolor genome mining

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

A genomics-guided approach for discovering and expressing cryptic metabolic pathways.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Bacterial small-molecule signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Palmitoylputrescine, an antibiotic isolated from the heterologous expression of DNA extracted from bromeliad tank water

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Shotgun cloning and heterologous expression of the patellamide gene cluster as a strategy to achieving sustained metabolite production

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via red/ET recombineering.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Metabolic engineering of Pseudomonas putida for methylmalonyl-CoA biosynthesis to enable complex heterologous secondary metabolite formation

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

GeneDesign: rapid, automated design of multikilobase synthetic genes

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Total synthesis of long DNA sequences: synthesis of a contiguous 32-kb polyketide synthase gene cluster.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Type II thioesterase restores activity of a NRPS module stalled with an aminoacyl-S-enzyme that cannot be elongated.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Active-site modifications of adenylation domains lead to hydrolysis of upstream nonribosomal peptidyl thioester intermediates.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Fancy footwork in the sequence space shuffle.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Designed divergent evolution of enzyme function

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Rational Design of Peptide Antibiotics by Targeted Replacement of Bacterial and Fungal Domains

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Modular organization of genes required for complex polyketide biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Architecture of mammalian fatty acid synthase at 4.5 A resolution

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Architecture of a fungal fatty acid synthase at 5 A resolution

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Structure of fungal fatty acid synthase and implications for iterative substrate shuttling

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

The structural basis for docking in modular polyketide biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Harnessing the potential of communication-mediating domains for the biocombinatorial synthesis of nonribosomal peptides

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Conformational Switches Modulate Protein Interactions in Peptide Antibiotic Synthetases

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

A mechanism-based aryl carrier protein/thiolation domain affinity probe

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Mechanism-based protein cross-linking probes to investigate carrier protein-mediated biosynthesis.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Genetic engineering in Streptomyces roseosporus to produce hybrid lipopeptide antibiotics

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Combinatorial biosynthesis of novel antibiotics related to daptomycin

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Chemoenzymatic design of acidic lipopeptide hybrids: new insights into the structure-activity relationship of daptomycin and A54145.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Biomimetic catalysis of intermodular aminoacyl transfer

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Functional and mechanistic analyses of biomimetic aminoacyl transfer reactions in de novo designed coiled coil peptides via rational active site engineering.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Mutational biosynthesis--a tool for the generation of structural diversity in the biosynthesis of antibiotics

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Mutasynthesis - uniting chemistry and genetics for drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Unusual sugar biosynthesis and natural product glycodiversification

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Directed biosynthesis of alkaloid analogs in the medicinal plant Catharanthus roseus

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Redesign of a central enzyme in alkaloid biosynthesis.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Using unnatural protein fusions to engineer resveratrol biosynthesis in yeast and Mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO.2007.7

1 reference

Dimensions Publication ID

25 July 2017

1048719834

0 references

1 reference