(Q39338520)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22657538%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

title

A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22657538%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

1 reference

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22657538%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

author name string

Lisa Phan

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22657538%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Andrew J Brown

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22657538%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

language of work or name

English

0 references

publication date

1 September 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22657538%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22657538%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

volume

446

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22657538%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22657538%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

page(s)

191-201

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22657538%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

cites work

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Cholesterol, statins and cancer

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The Akt-SREBP nexus: cell signaling meets lipid metabolism.

21 January 2018

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Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL

21 January 2018

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Modulation of liver X receptor signaling as novel therapy for prostate cancer

21 January 2018

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Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells.

21 January 2018

1 reference

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Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

21 January 2018

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Tocotrienols: Vitamin E beyond tocopherols

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Hypocholesterolemic activity of synthetic and natural tocotrienols

21 January 2018

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Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienols

21 January 2018

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Tocotrienol as a potential anticancer agent

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Cholesterol homeostasis in two commonly used human prostate cancer cell-lines, LNCaP and PC-3.

21 January 2018

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Cross-talk between the androgen receptor and the liver X receptor: implications for cholesterol homeostasis

21 January 2018

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Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase

21 January 2018

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The Polymerase Incomplete Primer Extension (PIPE) method applied to high-throughput cloning and site-directed mutagenesis

21 January 2018

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Improved PCR method for the creation of saturation mutagenesis libraries in directed evolution: application to difficult-to-amplify templates

21 January 2018

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Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).

21 January 2018

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Tissue culture media supplemented with 10% fetal calf serum contains a castrate level of testosterone

21 January 2018

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Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol

21 January 2018

1 reference

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Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

21 January 2018

1 reference

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SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR.

21 January 2018

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ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I.

21 January 2018

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Sterol regulators of cholesterol homeostasis and beyond: the oxysterol hypothesis revisited and revised

21 January 2018

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Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.

21 January 2018

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Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig

21 January 2018

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Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2.

21 January 2018

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SREBP in signal transduction: cholesterol metabolism and beyond

21 January 2018

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Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol

21 January 2018

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gamma-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells

21 January 2018

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Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide.

21 January 2018

1 reference

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Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis

21 January 2018

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Systematic and quantitative assessment of the ubiquitin-modified proteome

21 January 2018

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Direct demonstration of rapid degradation of nuclear sterol regulatory element-binding proteins by the ubiquitin-proteasome pathway

21 January 2018

1 reference

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The liver X receptor agonist T0901317 acts as androgen receptor antagonist in human prostate cancer cells

21 January 2018

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T0901317 is a dual LXR/FXR agonist

21 January 2018

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Induction of caspase-independent programmed cell death by vitamin E natural homologs and synthetic derivatives

21 January 2018

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Gamma-tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways

21 January 2018

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γ-Tocotrienol induces growth arrest through a novel pathway with TGFβ2 in prostate cancer

21 January 2018

1 reference

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Tocotrienol-rich fraction of palm oil induces cell cycle arrest and apoptosis selectively in human prostate cancer cells

21 January 2018

1 reference

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Postprandial levels of the natural vitamin E tocotrienol in human circulation

21 January 2018

1 reference

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Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans

21 January 2018

1 reference

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Cholesterol as a Potential Target for Castration-Resistant Prostate Cancer

21 January 2018

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Castration-resistant prostate cancer: current and emerging treatment strategies

21 January 2018

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In vivo evidence of gamma-tocotrienol as a chemosensitizer in the treatment of hormone-refractory prostate cancer

21 January 2018

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Gamma-tocotrienol as an effective agent in targeting prostate cancer stem cell-like population.

21 January 2018

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Putative fat fighter hits the middle man.

21 January 2018

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Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells.

21 January 2018

1 reference

19 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1016/S0021-9258(19)84879-2

Identifiers

DOI

10.1042/BJ20120545

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22657538%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

1 reference