(Q39370931)

11 September 2017

title

Cytoplasmatic compartmentalization by Bcr-Abl promotes TET2 loss-of-function in chronic myeloid leukemia (English)

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11 September 2017

main subject

chronic myeloid leukemia

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2

Nevena Veljkovic

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Enrica Borsi

object named as

Enrica Borsi

5

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Ilaria Iacobucci

7

object named as

Ilaria Iacobucci

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11 September 2017

Manuela Mancini

1

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11 September 2017

Nevena Veljkovic

2

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11 September 2017

Elisa Leo

3

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11 September 2017

Michela Aluigi

4

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11 September 2017

Chiara Galloni

6

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11 September 2017

Enza Barbieri

8

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11 September 2017

Maria Alessandra Santucci

9

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11 September 2017

publication date

1 August 2012

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Journal of Cellular Biochemistry

11 September 2017

published in

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11 September 2017

volume

113

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11 September 2017

issue

8

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11 September 2017

page(s)

2765-2774

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Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition.

11 September 2017

cites work

1 reference

Aberrant epigenetic landscape in cancer: how cellular identity goes awry

21 January 2018

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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P210 Bcr-abl tyrosine kinase interaction with histone deacetylase 1 modifies histone H4 acetylation and chromatin structure of chronic myeloid leukaemia haematopoietic progenitors

21 January 2018

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The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study group.

21 January 2018

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Acetylation of FOXO3a transcription factor in response to imatinib of chronic myeloid leukemia

21 January 2018

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Advances in DNA methylation: 5-hydroxymethylcytosine revisited

21 January 2018

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IGF-1 suppresses Bim expression in multiple myeloma via epigenetic and posttranslational mechanisms.

21 January 2018

1 reference

Targeting 14-3-3 sensitizes native and mutant BCR-ABL to inhibition with U0126, rapamycin and Bcl-2 inhibitor GX15-070

21 January 2018

1 reference

Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells.

21 January 2018

1 reference

MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation

21 January 2018

1 reference

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

21 January 2018

1 reference

ExPASy: The proteomics server for in-depth protein knowledge and analysis

21 January 2018

1 reference

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

21 January 2018

1 reference

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

21 January 2018

1 reference

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

21 January 2018

1 reference

Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia

21 January 2018

1 reference

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

21 January 2018

1 reference

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

21 January 2018

1 reference

Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors

21 January 2018

1 reference

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

21 January 2018

1 reference

TET proteins in malignant hematopoiesis

21 January 2018

1 reference

The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells

21 January 2018

1 reference

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

21 January 2018

1 reference

TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23).

21 January 2018

1 reference

CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia.

21 January 2018

1 reference

Persistent Cdk2 inactivation drives growth arrest of BCR-ABL-expressing cells in response to dual inhibitor of SRC and ABL kinases SKI606.

21 January 2018

1 reference

A new nonpeptidic inhibitor of 14-3-3 induces apoptotic cell death in chronic myeloid leukemia sensitive or resistant to imatinib

21 January 2018

1 reference

Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas

21 January 2018

1 reference

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

21 January 2018

1 reference

Antibody arrays identify protein-protein interactions in chronic myeloid leukaemia.

21 January 2018

1 reference

Bim and Bmf in tissue homeostasis and malignant disease

21 January 2018

1 reference

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

21 January 2018

1 reference

Reversion of epigenetically mediated BIM silencing overcomes chemoresistance in Burkitt lymphoma.

21 January 2018

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Epigenetic down-regulation of BIM expression is associated with reduced optimal responses to imatinib treatment in chronic myeloid leukaemia.

21 January 2018

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Transient potent BCR-ABL inhibition is sufficient to commit chronic myeloid leukemia cells irreversibly to apoptosis

21 January 2018

1 reference

A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes

21 January 2018

1 reference

Forkhead homeobox type O transcription factors in the responses to oxidative stress

21 January 2018

1 reference

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

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Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1.

21 January 2018

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Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2).

21 January 2018

1 reference

Application of the EIIP/ISM bioinformatics concept in development of new drugs

21 January 2018

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MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome

21 January 2018

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Key roles of histone methyltransferase and demethylase in leukemogenesis.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCB.24154

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11 September 2017

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