(Q39375855)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22437314%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

title

Acquired resistance to BRAF inhibition can confer cross-resistance to combined BRAF/MEK inhibition (English)

1 reference

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26 January 2020

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4

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26 January 2020

Richard F. Kefford

5

1 reference

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26 January 2020

author name string

Kavitha Gowrishankar

1

1 reference

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26 January 2020

Stephanie Snoyman

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22437314%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Gulietta M Pupo

3

1 reference

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26 January 2020

Helen Rizos

6

1 reference

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26 January 2020

language of work or name

English

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publication date

22 March 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22437314%20AND%20SRC:MED&resulttype=core&format=json

Journal of Investigative Dermatology

26 January 2020

published in

1 reference

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26 January 2020

volume

132

1 reference

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26 January 2020

issue

7

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26 January 2020

page(s)

1850-1859

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22437314%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

26 January 2020

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https://scigraph.springernature.com/pub.10.1038/jid.2012.63

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cites work

Reversing melanoma cross-resistance to BRAF and MEK inhibitors by co-targeting the AKT/mTOR pathway.

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https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

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7 January 2021

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

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https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

Mutations of the BRAF gene in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244)

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

MEK1 mutations confer resistance to MEK and B-RAF inhibition

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

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https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

Enforced expression of p14ARF induces p53-dependent cell cycle arrest but not apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

Oncogene-induced senescence does not require the p16(INK4a) or p14ARF melanoma tumor suppressors.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

Phase I/II study to assess safety, pharmacokinetics, and efficacy of the oral MEK 1/2 inhibitor GSK1120212 (GSK212) dosed in combination with the oral BRAF inhibitor GSK2118436 (GSK436)

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

MEK-independent survival of B-RAFV600E melanoma cells selected for resistance to apoptosis induced by the RAF inhibitor PLX4720.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

The "SWOT" of BRAF inhibition in melanoma: RAF inhibitors, MEK inhibitors or both?

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

Dual inhibition of (V600E)BRAF and the PI3K/AKT/mTOR pathway cooperates to induce apoptosis in melanoma cells through a MEK-independent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

IGFBP7 is not required for B-RAF-induced melanocyte senescence

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

Combinatorial treatments that overcome PDGFRβ-driven resistance of melanoma cells to V600EB-RAF inhibition

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

Understanding melanoma signaling networks as the basis for molecular targeted therapy

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

BRAF mutation predicts sensitivity to MEK inhibition

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021

Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.63

7 January 2021