(Q39404598)

English

Lipid rafts couple store-operated Ca2+ entry to constitutive activation of PKB/Akt in a Ca2+/calmodulin-, Src- and PP2A-mediated pathway and promote melanoma tumor growth

scientific article published on 27 January 2012

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scholarly article

1 reference

Europe PubMed Central

11 September 2017

Lipid rafts couple store-operated Ca2+ entry to constitutive activation of PKB/Akt in a Ca2+/calmodulin-, Src- and PP2A-mediated pathway and promote melanoma tumor growth (English)

1 reference

Europe PubMed Central

11 September 2017

1 reference

based on heuristic

inferred from title

author name string

Shlomit Fedida-Metula

1

1 reference

Europe PubMed Central

11 September 2017

Ben Feldman

2

1 reference

Europe PubMed Central

11 September 2017

Valeria Koshelev

3

1 reference

Europe PubMed Central

11 September 2017

Uliana Levin-Gromiko

4

1 reference

Europe PubMed Central

11 September 2017

Elena Voronov

5

1 reference

Europe PubMed Central

11 September 2017

Daniel Fishman

6

1 reference

Europe PubMed Central

11 September 2017

language of work or name

0 references

publication date

27 January 2012

1 reference

Europe PubMed Central

11 September 2017

1 reference

Europe PubMed Central

11 September 2017

33

1 reference

Europe PubMed Central

11 September 2017

4

1 reference

Europe PubMed Central

11 September 2017

740-750

1 reference

Europe PubMed Central

11 September 2017

The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Multiple pathways regulated by the tumor suppressor PP2A in transformation

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

MEK-independent survival of B-RAFV600E melanoma cells selected for resistance to apoptosis induced by the RAF inhibitor PLX4720.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

The Rafts of the Medusa: cholesterol targeting in cancer therapy

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Proteomic analysis of membrane rafts of melanoma cells identifies protein patterns characteristic of the tumor progression stage.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Elevated levels of cholesterol-rich lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesterol-depleting agents

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Ganglioside GD3 enhances adhesion signals and augments malignant properties of melanoma cells by recruiting integrins to glycolipid-enriched microdomains

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Cholesterol depletion induces anoikis-like apoptosis via FAK down-regulation and caveolae internalization

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Lipid rafts are required for Kit survival and proliferation signals

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Cholesterol sensitivity of endogenous and myristoylated Akt.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Targeting lipid rafts inhibits protein kinase B by disrupting calcium homeostasis and attenuates malignant properties of melanoma cells

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Coupling of mitochondria to store-operated Ca(2+)-signaling sustains constitutive activation of protein kinase B/Akt and augments survival of malignant melanoma cells

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Ca(2+)/calmodulin directly interacts with the pleckstrin homology domain of AKT1.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

NCAM-induced neurite outgrowth depends on binding of calmodulin to NCAM and on nuclear import of NCAM and fak fragments.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Myristoylation-regulated direct interaction between calcium-bound calmodulin and N-terminal region of pp60v-src

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Critical role for lipid raft-associated Src kinases in activation of PI3K-Akt signalling

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Lipid rafts determine clustering of STIM1 in endoplasmic reticulum-plasma membrane junctions and regulation of store-operated Ca2+ entry (SOCE)

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Lipid rafts modulate the activation but not the maintenance of store-operated Ca(2+) entry.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Altered tyrosine 527 phosphorylation and mitotic activation of p60c-src

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Orai1 is an essential pore subunit of the CRAC channel

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Impaired cholesterol biosynthesis in a neuronal cell line persistently infected with measles virus

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Src activation in melanoma and Src inhibitors as therapeutic agents in melanoma.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Tyrosine phosphatase inhibition triggers sustained canonical serine-dependent NFkappaB activation via Src-dependent blockade of PP2A.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Src kinase up-regulates the ERK cascade through inactivation of protein phosphatase 2A following cerebral ischemia

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Solution structure of calmodulin-W-7 complex: the basis of diversity in molecular recognition

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Targeting SET/I(2)PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Activation of the PI3K/Akt signaling pathway through P2Y₂ receptors by extracellular ATP is involved in osteoblastic cell proliferation

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Store-operated calcium channels: new perspectives on mechanism and function

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Orai1 and STIM1 are critical for breast tumor cell migration and metastasis

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Down-regulation of Orai3 arrests cell-cycle progression and induces apoptosis in breast cancer cells but not in normal breast epithelial cells.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

MS4A12 is a colon-selective store-operated calcium channel promoting malignant cell processes

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Involvement of store-operated calcium signaling in EGF-mediated COX-2 gene activation in cancer cells.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Orai1/CRACM1 overexpression suppresses cell proliferation via attenuation of the store-operated calcium influx-mediated signalling pathway in A549 lung cancer cells

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Histamine regulates cyclooxygenase 2 gene activation through Orai1-mediated NFκB activation in lung cancer cells

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Arrestin binding to calmodulin: a direct interaction between two ubiquitous signaling proteins

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Calmodulin-mediated regulation of the epidermal growth factor receptor.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Transcriptional regulation by calcium, calcineurin, and NFAT

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Calcium oscillations increase the efficiency and specificity of gene expression

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Akt/protein kinase b and glycogen synthase kinase-3beta signaling pathway regulates cell migration through the NFAT1 transcription factor.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Effects of the cholesterol-lowering compound methyl-beta-cyclodextrin in models of alpha-synucleinopathy

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Weekly cyclodextrin administration normalizes cholesterol metabolism in nearly every organ of the Niemann-Pick type C1 mouse and markedly prolongs life.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS021

21 January 2018

Identifiers

10.1093/CARCIN/BGS021

1 reference

Europe PubMed Central

11 September 2017

1 reference

Europe PubMed Central

11 September 2017

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