(Q40245982)

18 September 2017

title

Effects of the cholesterol-lowering compound methyl-beta-cyclodextrin in models of alpha-synucleinopathy (English)

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18 September 2017

2

Edward Rockenstein

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18 September 2017

6

Eliezer Masliah

1 reference

18 September 2017

Pazit Bar-On

1

1 reference

18 September 2017

Anthony Adame

series ordinal

3

1 reference

18 September 2017

Gilbert Ho

series ordinal

4

1 reference

18 September 2017

Makoto Hashimoto

series ordinal

5

1 reference

18 September 2017

language of work or name

English

0 references

publication date

1 August 2006

1 reference

Journal of Neurochemistry

18 September 2017

number of pages

14

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based on heuristic

inferred from page(s)

published in

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18 September 2017

volume

98

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18 September 2017

issue

4

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18 September 2017

page(s)

1032-1045

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Cyclodextrins in the treatment of a mouse model of Niemann-Pick C disease

18 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

A broken alpha -helix in folded alpha -Synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Niemann-Pick type C disease and intracellular cholesterol trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism.

21 January 2018

1 reference

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Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Lipid rafts of purified mouse brain synaptosomes prepared with or without detergent reveal different lipid and protein domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Cholesterol Modulates Amyloid Beta-peptide’s Membrane Interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Conformational properties of alpha-synuclein in its free and lipid-associated states

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Lipid rafts mediate the synaptic localization of alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Depletion of membrane cholesterol causes ligand-independent activation of Fas and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Cholesterol accumulation in NPC1-deficient neurons is ganglioside dependent

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions

21 January 2018

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Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Role of Protein Aggregation in Mitochondrial Dysfunction and Neurodegeneration in Alzheimer's and Parkinson's Diseases

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Altered p59Fyn kinase expression accompanies disease progression in Alzheimer's disease: implications for its functional role

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Non-A.beta. Component of Alzheimer's Disease Amyloid (NAC) is Amyloidogenic

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Adult nutrient intake as a risk factor for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Cellular cholesterol efflux mediated by cyclodextrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Ultrastructural localization of flotillin-1 to cholesterol-rich membrane microdomains, rafts, in rat brain tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Effects of methyl-beta-cyclodextrin on T lymphocytes lipid rafts with aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Dietary fatty acids and the risk of Parkinson disease: the Rotterdam study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Casein kinase II-mediated phosphorylation regulates alpha-synuclein/synphilin-1 interaction and inclusion body formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Molecular, anatomical, and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Cyclodextrins in topical drug formulations: theory and practice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

n-3 PUFA and membrane microdomains: a new frontier in bioactive lipid research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Spectrum of Parkinson's disease, Parkinson's dementia, and Lewy body dementia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

The role of cholesterol in pathogenesis of Alzheimer's disease: dual metabolic interaction between amyloid beta-protein and cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Membrane binding and self-association of alpha-synucleins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Yeast cells provide insight into alpha-synuclein biology and pathobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Xenopus flotillin1, a novel gene highly expressed in the dorsal nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Amyloid ion channels: a common structural link for protein-misfolding disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Aberrant phosphorylation of alpha-synuclein in human Niemann-Pick type C1 disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Interaction of Cholesterol with a Docosahexaenoic Acid-Containing Phosphatidylethanolamine: Trigger for Microdomain/Raft Formation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Altered Fatty Acid Composition of Dopaminergic Neurons Expressing α-Synuclein and Human Brains with α-Synucleinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Parkinson disease: etiology, pathogenesis and future of gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Does alpha-synuclein modulate dopaminergic synaptic content and tone at the synapse?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Functional rafts in cell membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Alpha-synuclein in Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Intracerebral grafting: a tool for the neurobiologist

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Reduced neuritic outgrowth and cell adhesion in neuronal cells transfected with human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Structure and dynamics of micelle-bound human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Immunocytochemical localization of synaptic vesicle-specific protein in lewy body-containing neurons in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Consequences of NPC1 and NPC2 loss of function in mammalian neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Order from disorder, corralling cholesterol with chaotic lipids. The role of polyunsaturated lipids in membrane raft formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Brain membrane cholesterol domains, aging and amyloid beta-peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Cholesterol and pathological processes in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Altered cholesterol metabolism in Niemann-Pick type C1 mouse brains affects mitochondrial function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

Involvement of cholesterol in the inhibitory effect of dimethyl-beta-cyclodextrin on P-glycoprotein and MRP2 function in Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

The Presence of Amyloid β-Protein in the Detergent-Insoluble Membrane Compartment of Human Neuroblastoma Cells†

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04017.X

10.1111/J.1471-4159.2006.04017.X

21 January 2018

Identifiers

DOI

1 reference

18 September 2017

1 reference