(Q39411766)

11 September 2017

title

c-Jun N-terminal kinase 1 negatively regulates osteoblastic differentiation induced by BMP2 via phosphorylation of Runx2 at Ser104. (English)

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11 September 2017

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Yi-Feng Huang

1

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11 September 2017

Jing-Jer Lin

2

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11 September 2017

Chao-Hsiung Lin

3

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11 September 2017

Yeu Su

4

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11 September 2017

Shih-Chieh Hung

5

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11 September 2017

publication date

1 May 2012

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Journal of Bone and Mineral Research

11 September 2017

published in

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11 September 2017

volume

27

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11 September 2017

issue

5

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11 September 2017

page(s)

1093-1105

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Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

11 September 2017

cites work

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Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

21 January 2018

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Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

21 January 2018

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Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization

21 January 2018

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Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells

21 January 2018

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BMP signaling is required for RUNX2-dependent induction of the osteoblast phenotype

21 January 2018

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Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12.

21 January 2018

1 reference

Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastic cells

21 January 2018

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Activation of p38 Mitogen-Activated Protein Kinase and c-Jun-NH2-Terminal Kinase by BMP-2 and Their Implication in the Stimulation of Osteoblastic Cell Differentiation

21 January 2018

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The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways.

21 January 2018

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TGFbeta signaling in growth control, cancer, and heritable disorders

21 January 2018

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Signaling cross-talk between TGF-beta/BMP and other pathways

21 January 2018

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MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1.

21 January 2018

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Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development

21 January 2018

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Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein

21 January 2018

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Activation of p38 Mitogen-Activated Protein Kinase Is Required for Osteoblast Differentiation

21 January 2018

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BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity

21 January 2018

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JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53.

21 January 2018

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Signal transduction by the JNK group of MAP kinases

21 January 2018

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Activation of c-Jun NH(2)-terminal kinase 1 increases cellular responsiveness to BMP-2 and decreases binding of inhibitory Smad6 to the type 1 BMP receptor

21 January 2018

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XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

21 January 2018

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IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition

21 January 2018

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p38 regulates expression of osteoblast-specific genes by phosphorylation of osterix

21 January 2018

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Activations of ERK1/2 and JNK by transforming growth factor beta negatively regulate Smad3-induced alkaline phosphatase activity and mineralization in mouse osteoblastic cells

21 January 2018

1 reference

A microRNA signature for a BMP2-induced osteoblast lineage commitment program

21 January 2018

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Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

21 January 2018

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Phosphorylation, acetylation and ubiquitination: the molecular basis of RUNX regulation

21 January 2018

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Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms

21 January 2018

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Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase

21 January 2018

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Inhibition of PI3K/p70 S6K and p38 MAPK cascades increases osteoblastic differentiation induced by BMP-2.

21 January 2018

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JNK activity is essential for Atf4 expression and late-stage osteoblast differentiation.

21 January 2018

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Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

21 January 2018

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To (TGF)beta or not to (TGF)beta: fine-tuning of Smad signaling via post-translational modifications

21 January 2018

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Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells

21 January 2018

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TNF-alpha inhibits BMP-induced osteoblast differentiation through activating SAPK/JNK signaling

21 January 2018

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Core-binding factor alpha 1 (Cbfa1) induces osteoblastic differentiation of C2C12 cells without interactions with Smad1 and Smad5.

21 January 2018

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The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp

21 January 2018

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Identification and functional characterization of ERK/MAPK phosphorylation sites in the Runx2 transcription factor.

21 January 2018

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The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice

21 January 2018

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Runx2 phosphorylation induced by fibroblast growth factor-2/protein kinase C pathways

21 January 2018

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Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor alpha1.

21 January 2018

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GSK-3beta controls osteogenesis through regulating Runx2 activity

21 January 2018

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JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JBMR.1548

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11 September 2017

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