(Q42834274)

English

Activation of p38 Mitogen-Activated Protein Kinase and c-Jun-NH2-Terminal Kinase by BMP-2 and Their Implication in the Stimulation of Osteoblastic Cell Differentiation

scientific article published on November 1, 2003

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scholarly article

1 reference

Europe PubMed Central

8 November 2017

Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation (English)

1 reference

Europe PubMed Central

8 November 2017

Activation of p38 Mitogen-Activated Protein Kinase and c-Jun-NH2-Terminal Kinase by BMP-2 and Their Implication in the Stimulation of Osteoblastic Cell Differentiation (English)

1 reference

10.1359/JBMR.2003.18.11.2060

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30 March 2024

cell differentiation

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based on heuristic

inferred from title

Orthopedics and sports medicine

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10.1359/JBMR.2003.18.11.2060

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30 March 2024

Jérome Guicheux

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J. Guicheux

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C. Ghayor

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G. Palmer

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author name string

J. Lemonnier

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A. Suzuki

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J. Caverzasio

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language of work or name

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National Center for Biotechnology Information

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publication date

1 November 2003

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8 November 2017

full work available at URL

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1359%2Fjbmr.2003.18.11.2060

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10.1359/JBMR.2003.18.11.2060

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https://academic.oup.com/jbmr/article-pdf/18/11/2060/56470681/5650181118.pdf

Portable Document Format

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Journal of Bone and Mineral Research

1 reference

Europe PubMed Central

8 November 2017

18

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Europe PubMed Central

8 November 2017

2060-2068

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Europe PubMed Central

8 November 2017

11

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Europe PubMed Central

8 November 2017

In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria

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24 May 2022

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Bone morphogenetic proteins: an update on basic biology and clinical relevance

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Regulation of differentiation pathway of skeletal mesenchymal cells in cell lines by transforming growth factor-beta superfamily

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Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts

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Effects of bone morphogenetic protein-2 on human neonatal calvaria cell differentiation

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The effects of bone morphogenetic protein-2, -4, and -6 on differentiation of rat osteoblast cells in vitro

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The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

6

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Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12.

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Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts

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TGF-beta signalling from cell membrane to nucleus through SMAD proteins

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Organization and regulation of mitogen-activated protein kinase signaling pathways

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MAP kinase pathways

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The stress-activated protein kinase pathways

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Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development

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Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

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Smads bind directly to the Jun family of AP-1 transcription factors

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ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling

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Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells

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Inhibition of PI3K/p70 S6K and p38 MAPK cascades increases osteoblastic differentiation induced by BMP-2.

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Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastic cells

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Murine osteoblastlike cells and the osteogenic cell MC3T3-E1 release a macrophage colony-stimulating activity in culture

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Mechanism of the mitogenic effect of fluoride on osteoblast-like cells: evidences for a G protein-dependent tyrosine phosphorylation process.

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Evidence for a role of p38 MAP kinase in expression of alkaline phosphatase during osteoblastic cell differentiation

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Tensile stress induces bone morphogenetic protein 4 in preosteoblastic and fibroblastic cells, which later differentiate into osteoblasts leading to osteogenesis in the mouse calvariae in organ culture

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Bone morphogenetic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells, MC3T3-E1

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Bone morphogenetic proteins (BMP-2 and BMP-3) promote growth and expression of the differentiated phenotype of rabbit chondrocytes and osteoblastic MC3T3-E1 cells in vitro

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The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells

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Stress-activated protein kinase/c-Jun N-terminal kinase (JNK) plays a part in endothelin-1-induced vascular endothelial growth factor synthesis in osteoblasts

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Divergent regulation by p44/p42 MAP kinase and p38 MAP kinase of bone morphogenetic protein-4-stimulated osteocalcin synthesis in osteoblasts

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10.1359/JBMR.2003.18.11.2060

1 reference

Europe PubMed Central

8 November 2017

1 reference

Europe PubMed Central

8 November 2017

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