(Q39417023)

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Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression.

scientific article published on 4 January 2012

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scholarly article

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19 January 2020

Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression (English)

1 reference

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19 January 2020

Orthoebolavirus zairense

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Marburgvirus (genus)

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Christina B Karsten

3

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19 January 2020

Stefan Pöhlmann

8

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19 January 2020

Stephanie Stanelle-Bertram

5

object named as

Stephanie Bertram

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19 January 2020

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Kerstin Gnirss

1

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19 January 2020

Annika Kühl

2

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19 January 2020

Ilona Glowacka

4

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19 January 2020

Franziska Kaup

6

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19 January 2020

Heike Hofmann

7

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19 January 2020

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4 January 2012

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19 January 2020

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19 January 2020

424

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19 January 2020

1

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19 January 2020

3-10

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19 January 2020

Leupeptins, new protease inhibitors from Actinomycetes

1 reference

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TMPRSS2 and TMPRSS4 facilitate trypsin-independent spread of influenza virus in Caco-2 cells.

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Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium

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Ligand-induced signaling in the absence of furin processing of Notch1.

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Ebola virus entry requires the cholesterol transporter Niemann-Pick C1

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Proteolytic activation of the 1918 influenza virus hemagglutinin

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7 January 2021

Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection

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7 January 2021

Type II transmembrane serine proteases in cancer and viral infections.

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7 January 2021

Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes

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7 January 2021

Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection

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7 January 2021

Ebola haemorrhagic fever

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Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection

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7 January 2021

Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63.

1 reference

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7 January 2021

Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response

1 reference

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7 January 2021

Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160

1 reference

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7 January 2021

Viral membrane fusion

1 reference

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7 January 2021

Ebola and marburg hemorrhagic fever

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7 January 2021

S protein of severe acute respiratory syndrome-associated coronavirus mediates entry into hepatoma cell lines and is targeted by neutralizing antibodies in infected patients

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7 January 2021

Biochemical and structural characterization of cathepsin L-processed Ebola virus glycoprotein: implications for viral entry and immunogenicity

1 reference

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7 January 2021

SARS-CoV, but not HCoV-NL63, utilizes cathepsins to infect cells: viral entry

1 reference

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7 January 2021

Proteolysis of the Ebola virus glycoproteins enhances virus binding and infectivity

1 reference

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7 January 2021

The Ebola virus glycoprotein and HIV-1 Vpu employ different strategies to counteract the antiviral factor tetherin

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7 January 2021

Comparative analysis of Ebola virus glycoprotein interactions with human and bat cells

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7 January 2021

Cutting edge: impairment of dendritic cells and adaptive immunity by Ebola and Lassa viruses

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7 January 2021

Zaire Ebola virus entry into human dendritic cells is insensitive to cathepsin L inhibition.

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7 January 2021

The signal peptide of the ebolavirus glycoprotein influences interaction with the cellular lectins DC-SIGN and DC-SIGNR.

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7 January 2021

Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2.

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7 January 2021

Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus

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Cell-penetrating inhibitors of calpain

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7 January 2021

Reverse genetics demonstrates that proteolytic processing of the Ebola virus glycoprotein is not essential for replication in cell culture

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7 January 2021

Proteolytic processing of the Ebola virus glycoprotein is not critical for Ebola virus replication in nonhuman primates

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Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding

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Analysis of filovirus entry into vero e6 cells, using inhibitors of endocytosis, endosomal acidification, structural integrity, and cathepsin (B and L) activity

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7 January 2021

Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein

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Alpha5beta1-integrin controls ebolavirus entry by regulating endosomal cathepsins

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A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.

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Efficient multiplication of human metapneumovirus in Vero cells expressing the transmembrane serine protease TMPRSS2.

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7 January 2021

A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry

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7 January 2021

Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry

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Downregulation of beta1 integrins by Ebola virus glycoprotein: implication for virus entry.

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Human macrophage C-type lectin specific for galactose and N-acetylgalactosamine promotes filovirus entry

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Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda

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Processing of the Ebola virus glycoprotein by the proprotein convertase furin

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A forward genetic strategy reveals destabilizing mutations in the Ebolavirus glycoprotein that alter its protease dependence during cell entry

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Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells

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Endoproteolytic processing of the ebola virus envelope glycoprotein: cleavage is not required for function.

1 reference

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12 December 2020

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10.1016/J.VIROL.2011.11.031

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19 January 2020

release_7gcx6rkzdvefnfp6oympu25ohy

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24 November 2022

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19 January 2020

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