(Q39425474)

11 September 2017

title

The role of tandem duplicator phenotype in tumour evolution in high-grade serous ovarian cancer (English)

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11 September 2017

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11 September 2017

Scott Newman

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Elizabeth M Batty

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Elizabeth M Batty

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Charlotte K Y Ng

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Charlotte K Y Ng

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James D Brenton

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James D Brenton

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author name string

Susanna L Cooke

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11 September 2017

Jian Xian

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11 September 2017

Jillian Temple

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11 September 2017

Jessica C M Pole

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11 September 2017

Simon P Langdon

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Paul A W Edwards

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11 September 2017

publication date

9 February 2012

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11 September 2017

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11 September 2017

volume

226

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11 September 2017

issue

5

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11 September 2017

page(s)

703-712

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How do real tumors become resistant to cisplatin?

11 September 2017

cites work

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Ovarian cancer: markers of response

21 January 2018

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Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary

21 January 2018

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A candidate precursor to serous carcinoma that originates in the distal fallopian tube.

21 January 2018

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Primary fallopian tube malignancies in BRCA-positive women undergoing surgery for ovarian cancer risk reduction

21 January 2018

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High-resolution single nucleotide polymorphism array analysis of epithelial ovarian cancer reveals numerous microdeletions and amplifications

21 January 2018

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A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

21 January 2018

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Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions

21 January 2018

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Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors.

21 January 2018

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Integrated genomic analyses of ovarian carcinoma

21 January 2018

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Somatic mutations in the BRCA1 gene in sporadic ovarian tumours.

21 January 2018

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EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer

21 January 2018

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Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

21 January 2018

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Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance

21 January 2018

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Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas.

21 January 2018

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Resistance to therapy caused by intragenic deletion in BRCA2

21 January 2018

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

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A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.

21 January 2018

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Complex landscapes of somatic rearrangement in human breast cancer genomes

21 January 2018

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Breast tumor copy number aberration phenotypes and genomic instability

21 January 2018

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Microsatellite instability and alteration of the expression of hMLH1 and hMSH2 in ovarian clear cell carcinoma

21 January 2018

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hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents

21 January 2018

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Human cancers express mutator phenotypes: origin, consequences and targeting

21 January 2018

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Inferring tumor progression from genomic heterogeneity

21 January 2018

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Distant metastasis occurs late during the genetic evolution of pancreatic cancer

21 January 2018

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Intra-tumour genetic heterogeneity and poor chemoradiotherapy response in cervical cancer.

21 January 2018

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Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

21 January 2018

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Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment.

21 January 2018

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Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia

21 January 2018

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Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma.

21 January 2018

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Fast and accurate long-read alignment with Burrows-Wheeler transform

21 January 2018

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PICNIC: an algorithm to predict absolute allelic copy number variation with microarray cancer data

21 January 2018

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Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma

21 January 2018

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Mechanisms of change in gene copy number

21 January 2018

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Mechanism of DNA double-strand break repair by non-homologous end joining

21 January 2018

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Comprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomes

21 January 2018

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Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes

21 January 2018

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Breast cancer genetic evolution: I. Data from cytogenetics and DNA content

21 January 2018

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Existence of two distinct processes of chromosomal evolution in near-diploid colorectal tumors

21 January 2018

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HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.

21 January 2018

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Altered ErbB receptor signaling and gene expression in cisplatin-resistant ovarian cancer

21 January 2018

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Massive genomic rearrangement acquired in a single catastrophic event during cancer development

21 January 2018

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Transcriptional consequences of genomic structural aberrations in breast cancer

21 January 2018

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Large duplications at reciprocal translocation breakpoints that might be the counterpart of large deletions and could arise from stalled replication bubbles

21 January 2018

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RAF gene fusion breakpoints in pediatric brain tumors are characterized by significant enrichment of sequence microhomology

21 January 2018

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

21 January 2018

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COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

21 January 2018

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Evolution of platinum resistance in high-grade serous ovarian cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/PATH.3980

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11 September 2017

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