(Q39443134)

12 September 2017

title

Bevacizumab attenuates major signaling cascades and eIF4E translation initiation factor in multiple myeloma cells (English)

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12 September 2017

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Oshrat Attar-Schneider

1

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12 September 2017

Liat Drucker

2

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12 September 2017

Victoria Zismanov

3

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12 September 2017

Shelly Tartakover-Matalon

4

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12 September 2017

Gloria Rashid

5

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12 September 2017

Michael Lishner

6

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12 September 2017

language of work or name

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14 November 2011

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12 September 2017

published in

Laboratory Investigation

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12 September 2017

volume

92

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12 September 2017

issue

2

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12 September 2017

page(s)

178-190

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

12 September 2017

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PI3-K/AKT/FKHR and MAPK signaling cascades are redundantly stimulated by a variety of cytokines and contribute independently to proliferation and survival of multiple myeloma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

AKT activity regulates the ability of mTOR inhibitors to prevent angiogenesis and VEGF expression in multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Taking aim at translation for tumor therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

c-Myc and eIF4F are components of a feedforward loop that links transcription and translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Antibody targeting of the insulin-like growth factor I receptor enhances the anti-tumor response of multiple myeloma to chemotherapy through inhibition of tumor proliferation and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Initiation of mRNA translation in oncogenesis: the role of eIF4E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Translational control of the proteome: relevance to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Tetraspanin-induced death of myeloma cell lines is autophagic and involves increased UPR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Response to trastuzumab, erlotinib, and bevacizumab, alone and in combination, is correlated with the level of human epidermal growth factor receptor-2 expression in human breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Cell culture detection of microvascular cell death in clinical specimens of human neoplasms and peripheral blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Inhibition of autophagy with 3-methyladenine results in impaired turnover of lysosomes and accumulation of lipofuscin-like material

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Co-administration of simvastatin and cytotoxic drugs is advantageous in myeloma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Tetraspanins affect myeloma cell fate via Akt signaling and FoxO activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Vascular endothelial growth factors and receptors: anti-angiogenic therapy in the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Intravenous immunoglobulins--understanding properties and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Signal transducer and activator of transcription 3 (STAT3) mediates amino acid inhibition of insulin signaling through serine 727 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90alpha and beta in multiple myeloma cells, which critically contribute to tumor-cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Tumor angiogenesis in the bone marrow of multiple myeloma patients and its alteration by thalidomide treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Targeting the translational machinery as a novel treatment strategy for hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Sumoylation of eIF4E activates mRNA translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Methods for studying signal-dependent regulation of translation factor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Ubiquitination and proteasome-dependent degradation of human eukaryotic translation initiation factor 4E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Role of 3'UTRs in the translation of mRNAs regulated by oncogenic eIF4E--a computational inference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

New drugs in multiple myeloma: mechanisms of action and phase I/II clinical findings.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Is cell death a critical end point for anticancer therapies or is cytostasis sufficient?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Mechanisms of cell death and survival in multiple myeloma (MM): Therapeutic implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Activation of AKT kinases in cancer: implications for therapeutic targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Protein kinase ERK contributes to differential responsiveness of human myeloma cell lines to IFNalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

mTOR: a protein kinase switching between life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Expression of VEGF and its receptors by myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Fetal stromal-dependent paracrine and intracrine vascular endothelial growth factor-a/vascular endothelial growth factor receptor-1 signaling promotes proliferation and motility of human primary myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

7 January 2021

Molecular aspects of multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

7 January 2021

Inhibition of VEGF induces cellular senescence in colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

7 January 2021

Overexpression of tetraspanins affects multiple myeloma cell survival and invasive potential

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

7 January 2021

Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

7 January 2021

10.1038/LABINVEST.2011.162

Identifiers

DOI

1 reference

12 September 2017

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