(Q39452730)

English

A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists (English)

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

0 references

7

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Europe PubMed Central

PMC publication ID

12 September 2017

object named as

Charles M Rudin

11

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12

object named as

Anirban Maitra

1 reference

Europe PubMed Central

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12 September 2017

author name string

Venugopal Chenna

1

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Europe PubMed Central

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12 September 2017

Chaoxin Hu

2

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Europe PubMed Central

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12 September 2017

Dipankar Pramanik

3

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Europe PubMed Central

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12 September 2017

Blake T Aftab

4

1 reference

Europe PubMed Central

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12 September 2017

Collins Karikari

5

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Nathaniel R Campbell

6

1 reference

Europe PubMed Central

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12 September 2017

Ming Zhao

8

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Europe PubMed Central

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12 September 2017

Michelle A Rudek

9

1 reference

Europe PubMed Central

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12 September 2017

Saeed R Khan

10

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Europe PubMed Central

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12 September 2017

publication date

25 October 2011

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Europe PubMed Central

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12 September 2017

Molecular Cancer Therapeutics

1 reference

Europe PubMed Central

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12 September 2017

11

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Europe PubMed Central

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12 September 2017

1

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12 September 2017

165-173

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Agents targeting the Hedgehog pathway for pancreatic cancer treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

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Vismodegib, a small-molecule inhibitor of the hedgehog pathway for the treatment of advanced cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

12 September 2017

Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

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Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma

1 reference

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12 September 2017

Hedgehog beyond medulloblastoma and basal cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

12 September 2017

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

12 September 2017

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

12 September 2017

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

12 September 2017

Paracrine Hedgehog signaling in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

12 September 2017

Current advances in research and clinical applications of PLGA-based nanotechnology

1 reference

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A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development.

1 reference

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12 September 2017

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

12 September 2017

Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

12 September 2017

The Gli code: an information nexus regulating cell fate, stemness and cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

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Identification of neovasculature using nestin in colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

12 September 2017

Hedgehog signalling in cancer formation and maintenance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

12 September 2017

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

12 September 2017

Biodegradable nanoparticles for drug and gene delivery to cells and tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

12 September 2017

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

12 September 2017

Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

1 reference

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12 September 2017

Altered neural cell fates and medulloblastoma in mouse patched mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

12 September 2017

Biodegradable long-circulating polymeric nanospheres

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

12 September 2017

Identification of an amplified, highly expressed gene in a human glioma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

12 September 2017

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

14 September 2017

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

14 September 2017

A paracrine requirement for hedgehog signalling in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

14 September 2017

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

14 September 2017

Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

15 June 2018

A frequent activated smoothened mutation in sporadic basal cell carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

15 June 2018

Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

21 August 2018

Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

21 August 2018

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256300

21 August 2018

The hedgehog pathway and pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22027695

12 December 2020

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Identifiers

10.1158/1535-7163.MCT-11-0341

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

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