(Q39456743)

English

Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1/2-mediated signal transmission pathway.

scientific article published on 18 October 2011

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22006246%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1/2-mediated signal transmission pathway (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22006246%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

5

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Europe PubMed Central

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14 January 2020

Dario Domenico Lofrumento

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22006246%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Giuseppe Nicolardi

7

1 reference

Europe PubMed Central

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14 January 2020

11

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14 January 2020

author name string

A Lombardi

1

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Europe PubMed Central

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14 January 2020

L Ulianich

2

1 reference

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14 January 2020

A S Treglia

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22006246%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

C Nigro

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22006246%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

C Garbi

8

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22006246%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

F Beguinot

9

1 reference

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14 January 2020

C Miele

10

1 reference

Europe PubMed Central

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14 January 2020

publication date

18 October 2011

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14 January 2020

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22006246%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

55

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14 January 2020

1

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14 January 2020

141-153

1 reference

Europe PubMed Central

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14 January 2020

https://scigraph.springernature.com/pub.10.1007/s00125-011-2315-1

0 references

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications

1 reference

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21 January 2018

Glucotoxicity and beta-cell failure in type 2 diabetes mellitus

1 reference

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21 January 2018

Type 2 diabetes-a matter of beta-cell life and death?

1 reference

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21 January 2018

Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance

1 reference

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21 January 2018

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

The role for endoplasmic reticulum stress in diabetes mellitus

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Proteomic analysis of O-GlcNAc modifications derived from streptozotocin and glucosamine induced beta-cell apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Glucosamine-induced endoplasmic reticulum stress promotes ApoB100 degradation: evidence for Grp78-mediated targeting to proteasomal degradation.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Endoplasmic reticulum stress in beta-cells and development of diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Probe-independent and direct quantification of insulin mRNA and growth hormone mRNA in enriched cell preparations.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Short-term regulation of insulin gene transcription by glucose

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

The insulin gene promoter. A simplified nomenclature.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Multiple signals induce endoplasmic reticulum stress in both primary and immortalized chondrocytes resulting in loss of differentiation, impaired cell growth, and apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Surviving endoplasmic reticulum stress is coupled to altered chondrocyte differentiation and function

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

ER stress is associated with dedifferentiation and an epithelial-to-mesenchymal transition-like phenotype in PC Cl3 thyroid cells.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Tyr phosphatase-mediated P-ERK inhibition suppresses senescence in EIA + v-raf transformed cells, which, paradoxically, are apoptosis-protected in a MEK-dependent manner

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Mixed-disulfide folding intermediates between thyroglobulin and endoplasmic reticulum resident oxidoreductases ERp57 and protein disulfide isomerase.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Reduction of O-GlcNAc protein modification does not prevent insulin resistance in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Folding of thyroglobulin in the calnexin/calreticulin pathway and its alteration by loss of Ca2+ from the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Demonstration of a Ca2+ requirement for thyroglobulin dimerization and export to the golgi complex

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2315-1

21 January 2018

Regulation of insulin gene transcription

1 reference

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21 January 2018

beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors

1 reference

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21 January 2018

Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.

1 reference

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21 January 2018

Pancreatic beta-cell-specific repression of insulin gene transcription by CCAAT/enhancer-binding protein beta. Inhibitory interactions with basic helix-loop-helix transcription factor E47.

1 reference

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21 January 2018

c-Jun represses the human insulin promoter activity that depends on multiple cAMP response elements

1 reference

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21 January 2018

Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion

1 reference

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21 January 2018

Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells

1 reference

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21 January 2018

Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells

1 reference

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21 January 2018

KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals

1 reference

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21 January 2018

Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose

1 reference

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Subnuclear localization of C/EBP beta is regulated by growth hormone and dependent on MAPK

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Recruitment of the extracellular signal-regulated kinase/ribosomal S6 kinase signaling pathway to the NFATc4 transcription activation complex

1 reference

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Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells

1 reference

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Regulation of basal cellular physiology by the homeostatic unfolded protein response

1 reference

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A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation

1 reference

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Measuring the balance between insulin synthesis and insulin release

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated O-linked N-acetylglucosamine metabolism in pancreatic beta-cells

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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