(Q39459586)

English

Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor

scientific article published on 11 October 2011

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor (English)

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

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Christoph Garbers

1

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Joachim Grötzinger

9

object named as

Joachim Grötzinger

0 references

Stefan Rose-John

object named as

Stefan Rose-John

11

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object named as

Gareth W Jones

3

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object named as

Simon A Jones

10

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author name string

Wolfgang Thaiss

2

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Georg H Waetzig

4

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Europe PubMed Central

PMC publication ID

12 September 2017

Inken Lorenzen

5

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Florence Guilhot

6

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Rami Lissilaa

7

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Walter G Ferlin

8

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Joachim Grötzinger

9

1 reference

Europe PubMed Central

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12 September 2017

Jürgen Scheller

12

1 reference

Europe PubMed Central

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12 September 2017

language of work or name

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publication date

11 October 2011

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Europe PubMed Central

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12 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

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12 September 2017

286

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

50

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

42959-42970

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

The pro- and anti-inflammatory properties of the cytokine interleukin-6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

12 September 2017

Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

12 September 2017

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

12 September 2017

Interleukin-6 regulates pancreatic alpha-cell mass expansion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

12 September 2017

IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

12 September 2017

Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

12 September 2017

Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

12 September 2017

STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

12 September 2017

Directing transition from innate to acquired immunity: defining a role for IL-6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

12 September 2017

The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

12 September 2017

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

12 September 2017

The soluble IL-6 receptors: serum levels and biological function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

12 September 2017

Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

12 September 2017

Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

12 September 2017

Soluble interleukin-6 receptors in inflammatory bowel disease: relation to circulating interleukin-6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

12 September 2017

Interleukin-6 family of cytokines and gp130

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

12 September 2017

Transgenic blockade of interleukin 6 transsignaling abrogates inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

14 September 2017

Soluble receptors for cytokines and growth factors: generation and biological function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

14 September 2017

Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 on IL-6 responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

25 September 2017

In vivo and in vitro activities of the gp130-stimulating designer cytokine Hyper-IL-6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

25 September 2017

Interleukin-6 in biology and medicine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

25 September 2017

Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

15 June 2018

Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

15 June 2018

TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

15 June 2018

Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

15 June 2018

The soluble interleukin-6 receptor is generated by shedding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

15 June 2018

Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

15 June 2018

Although IL-6 trans-signaling is sufficient to drive local immune responses, classical IL-6 signaling is obligate for the induction of T cell-mediated autoimmunity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

21 August 2018

Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

21 August 2018

Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

21 August 2018

Interleukin-6 receptor signaling. II. Bio-availability of interleukin-6 in serum.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234812

21 August 2018

Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model*

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.295758

21 January 2018

Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.295758

21 January 2018

Plasma clearance, organ distribution and target cells of interleukin-6/hepatocyte-stimulating factor in the rat

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.295758

21 January 2018

Processing of tumour necrosis factor-α precursor by metalloproteinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.295758

21 January 2018

Actemra poised to launch IL-6 inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21990364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/21990364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21990364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The hepatic interleukin-6 receptor Down-regulation of the interleukin-6 binding subunit (gp80) by its ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/21990364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/21990364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased and highly stable levels of functional soluble interleukin-6 receptor in sera of patients with monoclonal gammopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21990364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential shedding of the two subunits of the interleukin-6 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21990364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A bioactive designer cytokine for human hematopoietic progenitor cell expansion

1 reference

https://pubmed.ncbi.nlm.nih.gov/21990364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting Edge: Trans-Signaling via the Soluble IL-6R Abrogates the Induction of FoxP3 in Naive CD4+CD25- T Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21990364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/21990364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.295758

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

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