(Q39471013)

12 September 2017

title

Amyotrophic lateral sclerosis-linked mutant VAPB enhances TDP-43-induced motor neuronal toxicity (English)

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amyotrophic lateral sclerosis

12 September 2017

main subject

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2

Masaaki Matsuoka

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12 September 2017

Hiroaki Suzuki

1

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12 September 2017

language of work or name

English

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publication date

20 October 2011

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Journal of Neurochemistry

12 September 2017

published in

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12 September 2017

volume

119

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12 September 2017

issue

5

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12 September 2017

page(s)

1099-1107

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ALS: a disease of motor neurons and their nonneuronal neighbors

12 September 2017

cites work

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Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons

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Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosis

21 January 2018

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TAR DNA-binding protein 43 in neurodegenerative disease

21 January 2018

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Review: transactive response DNA-binding protein 43 (TDP-43): mechanisms of neurodegeneration

21 January 2018

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FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

21 January 2018

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VAPB interacts with and modulates the activity of ATF6.

21 January 2018

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Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis

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Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

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Bim and Noxa are candidates to mediate the deleterious effect of the NF-kappa B subunit RelA in cerebral ischemia.

21 January 2018

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Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8)

21 January 2018

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ER stress and unfolded protein response in amyotrophic lateral sclerosis

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A critical role of neural-specific JNK3 for ischemic apoptosis

21 January 2018

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TDP-43 is a transcriptional repressor: the testis-specific mouse acrv1 gene is a TDP-43 target in vivo

21 January 2018

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21 January 2018

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A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis

21 January 2018

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ER stress triggers apoptosis by activating BH3-only protein Bim

21 January 2018

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Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis

21 January 2018

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21 January 2018

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TDP-43 toxicity is mediated by the unfolded protein response-unrelated induction of C/EBP homologous protein expression

21 January 2018

1 reference

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ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB.

21 January 2018

1 reference

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TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage

21 January 2018

1 reference

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Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology.

21 January 2018

1 reference

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Genetic strategies to study TDP-43 in rodents and to develop preclinical therapeutics for amyotrophic lateral sclerosis

21 January 2018

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10.1111/J.1471-4159.2011.07491.X

21 January 2018

Identifiers

DOI

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12 September 2017

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