(Q39472176)

English

The oncogenic phosphatase PPM1D confers cisplatin resistance in ovarian carcinoma cells by attenuating checkpoint kinase 1 and p53 activation.

scientific article published on 19 September 2011

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21927021%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

The oncogenic phosphatase PPM1D confers cisplatin resistance in ovarian carcinoma cells by attenuating checkpoint kinase 1 and p53 activation (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21927021%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

ovarian carcinoma

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Benjamin K Tsang

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21927021%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

author name string

A Y Ali

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21927021%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

M R Abedini

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21927021%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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publication date

19 September 2011

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21927021%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21927021%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

31

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12 February 2020

17

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Europe PubMed Central

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12 February 2020

2175-2186

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21927021%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Cisplatin induces p53-dependent FLICE-like inhibitory protein ubiquitination in ovarian cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

WIP1 phosphatase is a negative regulator of NF-kappaB signalling

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

The structure and expression of the murine wildtype p53-induced phosphatase 1 (Wip1) gene

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Characterization of the active site and a unique uncompetitive inhibitor of the PPM1-type protein phosphatase PPM1D.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Cisplatinum and taxol induce different patterns of p53 phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Akt promotes cisplatin resistance in human ovarian cancer cells through inhibition of p53 phosphorylation and nuclear function

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Chk1 instability is coupled to mitotic cell death of p53-deficient cells in response to virus-induced DNA damage signaling

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

p53: puzzle and paradigm

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Regulation of p53 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Homeostatic regulation of base excision repair by a p53-induced phosphatase: linking stress response pathways with DNA repair proteins.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Recombinant adeno-associated virus encoding Epstein-Barr virus latent membrane proteins fused with heat shock protein as a potential vaccine for nasopharyngeal carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Development of resistance to a trinuclear platinum complex in ovarian carcinoma cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Abrogation of the radiation-induced G2 checkpoint by the staurosporine derivative UCN-01 is associated with radiosensitisation in a subset of colorectal tumour cell lines

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumours

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Gambogic acid triggers DNA damage signaling that induces p53/p21(Waf1/CIP1) activation through the ATR-Chk1 pathway

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Characterization of intraperitoneal, orthotopic, and metastatic xenograft models of human ovarian cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

PPM1D is a potential therapeutic target in ovarian clear cell carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Cisplatin-induced DNA damage activates replication checkpoint signaling components that differentially affect tumor cell survival

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Regulation of apoptosis-inducing factor-mediated, cisplatin-induced apoptosis by Akt

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

DNA damage-induced S phase arrest in human breast cancer depends on Chk1, but G2 arrest can occur independently of Chk1, Chk2 or MAPKAPK2.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

21 January 2018

Knockdown of Chk1 sensitizes human colon carcinoma HCT116 cells in a p53-dependent manner to lidamycin through abrogation of a G2/M checkpoint and induction of apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

31 March 2020

UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

31 March 2020

Akt-mediated cisplatin resistance in ovarian cancer: modulation of p53 action on caspase-dependent mitochondrial death pathway

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.399

31 March 2020

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