(Q39491810)

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Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.

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2 January 2020

Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs (English)

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2 January 2020

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2 January 2020

Giancarlo Biagini

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2 January 2020

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Gemma Ellis

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2 January 2020

Richard K Amewu

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Richard Amewu

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2 January 2020

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Amy E Mercer

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2 January 2020

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Paul A Stocks

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2 January 2020

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Patrick G Bray

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2 January 2020

Victoria E Barton

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2 January 2020

Mohammed Al-Helal

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2 January 2020

Michael Jones

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2 January 2020

Nuna C Araujo

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2 January 2020

Peter Gibbons

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2 January 2020

Ruth H Hughes

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2 January 2020

Jill Davies

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2 January 2020

Paul M O'Neill

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2 January 2020

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1 January 2007

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2 January 2020

Angewandte Chemie International Edition

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2 January 2020

46

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2 January 2020

33

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2 January 2020

6278-6283

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2 January 2020

A medicinal chemistry perspective on artemisinin and related endoperoxides

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

Knowledge of the proposed chemical mechanism of action and cytochrome p450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

Synthetic peroxides as antimalarials

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

Qinghaosu (artemisinin): an antimalarial drug from China

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

Artemisinin: mechanisms of action, resistance and toxicity

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

Artemisinins: mechanisms of action and potential for resistance

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

The interaction of artemisinin with malarial hemozoin.

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

Characterization of the Alkylation Product of Heme by the Antimalarial Drug Artemisinin We are grateful to the CNRS for financial support, and to the French Ministery of Education for a PhD grant to J.C. Dr. Yannick Coppel (LCC-CNRS) is gratefully a

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

Alkylating capacity and reaction products of antimalarial trioxanes after activation by a heme model

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

From mechanistic studies on artemisinin derivatives to new modular antimalarial drugs

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

The antimalarial drug artemisinin alkylates heme in infected mice

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

An overview of drug combination analysis with isobolograms

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

Artemisone--a highly active antimalarial drug of the artemisinin class

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

Kinetics of iron-mediated artemisinin degradation: effect of solvent composition and iron salt

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

Artemisinins target the SERCA of Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

Synthesis and antimalarial activities of fluoroalkyl derivatives of dihydroartemisinin

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

Novel, potent, semisynthetic antimalarial carba analogues of the first-generation 1,2,4-trioxane artemether

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

Artemisinin and its derivatives are transported by a vacuolar-network of Plasmodium falciparum and their anti-malarial activities are additive with toxic sphingolipid analogues that block the network

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

The pH of the digestive vacuole of Plasmodium falciparum is not associated with chloroquine resistance

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening.

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

Cholic acid derivatives as 1,2,4,5-tetraoxane carriers: structure and antimalarial and antiproliferative activity.

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

Identification of an antimalarial synthetic trioxolane drug development candidate

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277).

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

Methyl-Substituted Dispiro-1,2,4,5-tetraoxanes: Correlations of Structural Studies with Antimalarial Activity

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200604697

21 January 2018

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