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Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis.
scientific article published on January 2011
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3113227
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21587233%20AND%20SRC:MED&resulttype=core&format=json
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1 February 2020
title
Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis
(English)
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PMCID
3113227
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1 February 2020
author
René H. Medema
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3
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3113227
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21587233%20AND%20SRC:MED&resulttype=core&format=json
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1 February 2020
Adrian Saurin
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1
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3113227
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21587233%20AND%20SRC:MED&resulttype=core&format=json
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1 February 2020
Geert Kops
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5
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3113227
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1 February 2020
author name string
Maike S van der Waal
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2
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3113227
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1 February 2020
Susanne M A Lens
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4
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3113227
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1 February 2020
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English
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publication date
1 January 2011
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3113227
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1 February 2020
published in
Nature Communications
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3113227
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1 February 2020
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2
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1 February 2020
page(s)
316
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3113227
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retrieved
1 February 2020
copyright license
Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported
start time
17 May 2011
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copyrighted
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11 June 2022
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based on heuristic
inferred from PubMed Central ID database lookup
exact match
https://scigraph.springernature.com/pub.10.1038/ncomms1319
0 references
cites work
Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Mimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Autophosphorylation-dependent activation of human Mps1 is required for the spindle checkpoint
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
MAD contortions: conformational dimerization boosts spindle checkpoint signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
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13 September 2017
Chromosomal passengers: conducting cell division
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
The spindle-assembly checkpoint in space and time
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
The conserved KMN network constitutes the core microtubule-binding site of the kinetochore
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Kinetochore microtubule dynamics and attachment stability are regulated by Hec1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
The anaphase promoting complex/cyclosome: a machine designed to destroy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Timing and checkpoints in the regulation of mitotic progression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Spindle checkpoint protein dynamics at kinetochores in living cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
Temporal and spatial control of cyclin B1 destruction in metaphase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
13 September 2017
The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule kinetochore interactions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
14 September 2017
Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
15 June 2018
Release of Mps1 from kinetochores is crucial for timely anaphase onset.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113227
retrieved
15 June 2018
S. pombe aurora kinase/survivin is required for chromosome condensation and the spindle checkpoint attachment response
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21587233
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/NCOMMS1319
1 reference
stated in
Europe PubMed Central
PMCID
3113227
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21587233%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
ADS bibcode
2011NatCo...2..316S
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Internet Archive ID
pubmed-PMC3113227
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PMCID
3113227
1 reference
stated in
Europe PubMed Central
PMCID
3113227
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21587233%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
PubMed ID
21587233
1 reference
stated in
Europe PubMed Central
PMCID
3113227
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21587233%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
ResearchGate publication ID
51141435
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