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Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function
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scholarly article
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title
Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function
(English)
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main subject
cell biology
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author
Panagis Filippakopoulos
series ordinal
3
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Meera Soundararajan
object named as
Meera Soundararajan
series ordinal
4
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Stefan Knapp
object named as
Stefan Knapp
series ordinal
14
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Nicholas Kwiatkowski
series ordinal
1
object named as
Nicholas Kwiatkowski
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Nathanael Gray
series ordinal
15
object named as
Nathanael S Gray
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Hwan Geun Choi
series ordinal
7
object named as
Hwan Geun Choi
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Taebo Sim
series ordinal
8
object named as
Taebo Sim
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author name string
Nannette Jelluma
series ordinal
2
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Michael S Manak
series ordinal
5
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Mijung Kwon
series ordinal
6
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Quinn L Deveraux
series ordinal
9
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Sabine Rottmann
series ordinal
10
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David Pellman
series ordinal
11
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Jagesh V Shah
series ordinal
12
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Geert J P L Kops
series ordinal
13
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publication date
May 2010
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published in
Nature Chemical Biology
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volume
6
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page(s)
359-68
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issue
5
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cites work
Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
Structural and mechanistic insights into Mps1 kinase activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
Plk4-induced centriole biogenesis in human cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
Mutations of mitotic checkpoint genes in human cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
Extension of life-span by introduction of telomerase into normal human cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
The spindle-assembly checkpoint in space and time
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
A quantitative analysis of kinase inhibitor selectivity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
20 March 2017
A small molecule-kinase interaction map for clinical kinase inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
7 April 2017
Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
7 April 2017
Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
Regulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
Centrosome amplification can initiate tumorigenesis in flies.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
Extra centrosomes and/or chromosomes prolong mitosis in human cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
Preventing the degradation of mps1 at centrosomes is sufficient to cause centrosome reduplication in human cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
Mps1 activation loop autophosphorylation enhances kinase activity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
Mitotic drug targets and the development of novel anti-mitotic anticancer drugs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
Ablation of the spindle assembly checkpoint by a compound targeting Mps1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
Generating chromosome instability through the simultaneous deletion of Mad2 and p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
Kinetochore localization of spindle checkpoint proteins: who controls whom?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
Spindle checkpoint protein dynamics at kinetochores in living cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
New alleles of the yeast MPS1 gene reveal multiple requirements in spindle pole body duplication
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
29 September 2017
The mouse Mps1p-like kinase regulates centrosome duplication
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
2 June 2018
A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
27 November 2018
Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
27 November 2018
Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857554
retrieved
27 November 2018
Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20383151
retrieved
12 December 2020
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inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/NCHEMBIO.345
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3560158
Dimensions Publication ID
1024590229
0 references
Fatcat ID
release_wr5uvxgcwfa4narnl3p76rfsou
0 references
OpenCitations bibliographic resource ID
3560158
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3560158
PMCID
2857554
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3560158
PubMed ID
20383151
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3560158
ResearchGate publication ID
43100117
0 references
Springer Nature article ID
10.1038/nchembio.345
0 references
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