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Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling
scientific article published on 21 July 2016
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Europe PubMed Central
PMC publication ID
5295388
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27458164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
title
Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
5295388
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27458164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
main subject
Src-like-adaptor 2
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GOA release 2020-03-11
author
Hui Zhao
series ordinal
6
1 reference
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Europe PubMed Central
PMC publication ID
5295388
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27458164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
Lars Rönnstrand
series ordinal
7
1 reference
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Europe PubMed Central
PMC publication ID
5295388
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27458164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
Julhash U Kazi
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8
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Europe PubMed Central
PMC publication ID
5295388
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27458164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
Rohit A Chougule
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2
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Rohit A Chougule
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Europe PubMed Central
PMC publication ID
5295388
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27458164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
Sausan A Moharram
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1
object named as
Sausan A Moharram
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Europe PubMed Central
PMC publication ID
5295388
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27458164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
author name string
Xianwei Su
series ordinal
3
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Europe PubMed Central
PMC publication ID
5295388
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27458164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
Tianfeng Li
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4
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Europe PubMed Central
PMC publication ID
5295388
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27458164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
Jianmin Sun
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5
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Europe PubMed Central
PMC publication ID
5295388
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27458164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
language of work or name
English
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publication date
1 September 2016
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Europe PubMed Central
PMC publication ID
5295388
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27458164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
published in
Oncotarget
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Europe PubMed Central
PMC publication ID
5295388
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27458164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
volume
7
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Europe PubMed Central
PMC publication ID
5295388
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27458164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
issue
36
1 reference
stated in
Europe PubMed Central
PMC publication ID
5295388
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27458164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
page(s)
57770-57782
1 reference
stated in
Europe PubMed Central
PMC publication ID
5295388
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27458164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
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ImageJ
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Europe PubMed Central
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11 June 2022
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5295388/fullTextXML
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cites work
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PubMed Central
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The tyrosine kinase CSK associates with FLT3 and c-Kit receptors and regulates downstream signaling
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Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling.
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FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia
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Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3.
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Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3.
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Octa-arginine mediated delivery of wild-type Lnk protein inhibits TPO-induced M-MOK megakaryoblastic leukemic cell growth by promoting apoptosis
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Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3
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Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome
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The Src-like adaptor protein 2 regulates colony-stimulating factor-1 receptor signaling and down-regulation
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Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk
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14 September 2017
Src-like adaptor protein (Slap) is a negative regulator of mitogenesis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5295388
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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
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Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5295388
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Oncogenic Flt3 receptors display different specificity and kinetics of autophosphorylation
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Src family kinases are involved in the differential signaling from two splice forms of c-Kit
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Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis
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Src-like-adaptor protein (SLAP) differentially regulates normal and oncogenic c-Kit signaling.
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15 June 2018
SRC is a signaling mediator in FLT3-ITD- but not in FLT3-TKD-positive AML.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5295388
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15 June 2018
The presence or absence of IL-3 during long-term culture of Flt3-ITD and c-Kit-D816V expressing Ba/F3 cells influences signaling outcome.
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21 August 2018
Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2
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retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.18632/ONCOTARGET.10760
1 reference
stated in
Europe PubMed Central
PMC publication ID
5295388
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27458164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
PMC publication ID
5295388
1 reference
stated in
Europe PubMed Central
PMC publication ID
5295388
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27458164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
PubMed publication ID
27458164
1 reference
stated in
Europe PubMed Central
PMC publication ID
5295388
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27458164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
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