(Q39561884)

English

The statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes

scientific article published on 9 April 2011

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

The statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes (English)

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

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Nick Plant

5

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author name string

Katharine Howe

1

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Faizah Sanat

2

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Alfred E Thumser

3

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Europe PubMed Central

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13 September 2017

Tanya Coleman

4

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Europe PubMed Central

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13 September 2017

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publication date

9 April 2011

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Europe PubMed Central

PubMed publication ID

13 September 2017

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Europe PubMed Central

PubMed publication ID

13 September 2017

41

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Europe PubMed Central

PubMed publication ID

13 September 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

519-529

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR.

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Estrogen receptor alpha binds to peroxisome proliferator-activated receptor response element and negatively interferes with peroxisome proliferator-activated receptor gamma signaling in breast cancer cells

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Regulation of cholesterol metabolism

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

The ratio of constitutive androstane receptor to pregnane X receptor determines the activity of guggulsterone against the Cyp2b10 promoter

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

A pharmacophore for human pregnane X receptor ligands

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Statins and transcriptional regulation: the FXR connection

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Molecular mechanism for inhibition of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase by rosuvastatin

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor.

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Similarities and differences

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

HDL as a target in the treatment of atherosclerotic cardiovascular disease

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Effect of rosuvastatin on low-density lipoprotein cholesterol in patients with hypercholesterolemia

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Transcriptional analysis of the orphan nuclear receptor constitutive androstane receptor (NR1I3) gene promoter: identification of a distal glucocorticoid response element

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

The human cytochrome P450 sub-family: transcriptional regulation, inter-individual variation and interaction networks

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Nuclear receptors: the controlling force in drug metabolism of the liver?

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Role of FXR in regulating bile acid homeostasis and relevance for human diseases

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

New insights into mechanisms of statin-associated myotoxicity

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Molecular basis of statin-associated myopathy

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Pharmacokinetic and pharmacodynamic interactions between simvastatin and diltiazem in patients with hypercholesterolemia and hypertension

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Effects of acid and lactone forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on the induction of MDR1 expression and function in LS180 cells.

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Interaction networks: coordinating responses to xenobiotic exposure

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.569773

21 January 2018

Identifiers

10.3109/00498254.2011.569773

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

ResearchGate publication ID

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