(Q39571283)

English

The mitochondria-independent cytotoxic effect of nelfinavir on leukemia cells can be enhanced by sorafenib-mediated mcl-1 downregulation and mitochondrial membrane destabilization

scientific article published on 27 January 2010

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

The mitochondria-independent cytotoxic effect of nelfinavir on leukemia cells can be enhanced by sorafenib-mediated mcl-1 downregulation and mitochondrial membrane destabilization (English)

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

0 references

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

4

object named as

Klaus Friese

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

author name string

Ansgar Brüning

1

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Martina Rahmeh

2

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Andrea Gingelmaier

3

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

language of work or name

1 reference

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publication date

27 January 2010

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Molecular Cancer

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

9

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

19

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

The impact of nelfinavir exposure on cancer development among a large cohort of HIV-infected patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

Nelfinavir/ritonavir reduces acinar injury but not inflammation during mouse caerulein pancreatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

Anti-HIV drugs for cancer therapeutics: back to the future?

1 reference

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14 September 2017

HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

Unique biology of Mcl-1: therapeutic opportunities in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

HIV protease inhibitors impact on apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress.

1 reference

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14 September 2017

Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

HIV protease inhibitors modulate apoptosis signaling in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes

1 reference

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14 September 2017

An updated systematic overview of triple combination therapy in antiretroviral-naive HIV-infected adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

Role of mitochondria as the gardens of cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

Overview of cell death signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

Mcl-1 regulation and its role in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

Nelfinavir: an update on its use in HIV infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

Nelfinavir induces mitochondria protection by ERK1/2-mediated mcl-1 stabilization that can be overcome by sorafenib

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

Nelfinavir induces the unfolded protein response in ovarian cancer cells, resulting in ER vacuolization, cell cycle retardation and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

Nelfinavir induces TRAIL receptor upregulation in ovarian cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

14 September 2017

Importance of the Bcl-2 family in cell death regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

25 September 2017

Phase I trial of the human immunodeficiency virus protease inhibitor nelfinavir and chemoradiation for locally advanced pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

21 August 2018

Validation and toxicity of PI3K/Akt pathway inhibition by HIV protease inhibitors in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

21 August 2018

Microarray analysis reveals glucocorticoid-regulated survival genes that are associated with inhibition of apoptosis in breast epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

21 August 2018

Antiapoptotic mechanism of HIV protease inhibitors: preventing mitochondrial transmembrane potential loss

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

21 August 2018

A preliminary evaluation of nelfinavir mesylate, an inhibitor of human immunodeficiency virus (HIV)-1 protease, to treat HIV infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836985

21 August 2018

Immunomagnetic enrichment of disseminated tumor cells in bone marrow and blood of breast cancer patients by the Thomsen-Friedenreich-Antigen

1 reference

https://pubmed.ncbi.nlm.nih.gov/20105315

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacokinetics of nelfinavir combined with efavirenz and stavudine during rescue treatment of heavily pretreated HIV-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20105315

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biomedicine. HIV drug shows promise as potential cancer treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/20105315

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mcl-1: the 1 in CLL

1 reference

https://pubmed.ncbi.nlm.nih.gov/20105315

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benefits and adverse effects of anti-emetic glucocorticoids in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20105315

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1476-4598-9-19

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1476-4598-9-19

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

ResearchGate publication ID

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