(Q39575365)

English

Characterization of three diaminopyrimidines as potent and selective antagonists of P2X3 and P2X2/3 receptors with in vivo efficacy in a pain model

scientific article published on July 2011

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Characterization of three diaminopyrimidines as potent and selective antagonists of P2X3 and P2X2/3 receptors with in vivo efficacy in a pain model (English)

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

author name string

E Ballini

1

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

C Virginio

2

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

S J Medhurst

3

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

S G Summerfield

4

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

L Aldegheri

5

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

A Buson

6

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

C Carignani

7

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Y H Chen

8

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

A Giacometti

9

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

I Lago

10

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

A J Powell

11

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

W Jarolimek

12

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

language of work or name

0 references

publication date

1 July 2011

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

British Journal of Pharmacology

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

163

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

6

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

1315-1325

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Recommendations for the pharmacological management of neuropathic pain: an overview and literature update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

Signaling at purinergic P2X receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

Challenges for blood-brain barrier (BBB) screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

Investigation into the role of P2X(3)/P2X(2/3) receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

An overview of neuropathic pain: syndromes, symptoms, signs, and several mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

Neuropathic pain: evidence matters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X(3) allosteric modulator, cibacron blue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

Cloning, distribution and functional analysis of the type III sodium channel from human brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

P2 purinergic receptors: modulation of cell function and therapeutic potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

Neuronal plasticity: increasing the gain in pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

Pharmacology of cloned P2X receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

Molecular and functional characterization of human P2X(2) receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

Mammalian expression of transmembrane receptors for pharmaceutical applications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

A P2X purinoceptor expressed by a subset of sensory neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

Mechanism of action of species-selective P2X(7) receptor antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

Purine nucleoside-dependent inhibition of cellular proliferation in 1321N1 human astrocytoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

14 September 2017

Functional characterization of the P2X(4) receptor orthologues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

25 September 2017

A novel and efficient method for the stable expression of heteromeric ion channels in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

25 September 2017

Effects of divalent cations, protons and calmidazolium at the rat P2X7 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

25 September 2017

Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

25 September 2017

Purinergic receptors: their role in nociception and primary afferent neurotransmission

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

25 September 2017

AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

15 June 2018

Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

15 June 2018

Cell damage excites nociceptors through release of cytosolic ATP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

15 June 2018

Effects of spinally administered P2X receptor agonists and antagonists on the responses of dorsal horn neurones recorded in normal, carrageenan-inflamed and neuropathic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

15 June 2018

A unifying purinergic hypothesis for the initiation of pain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

15 June 2018

Antinociceptive effect of intrathecally administered P2-purinoceptor antagonists in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

15 June 2018

A patch-clamp study of bovine chromaffin cells and of their sensitivity to acetylcholine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

15 June 2018

Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

21 August 2018

Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

21 August 2018

Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

21 August 2018

Pharmacological properties of rat alpha 7 nicotinic receptors expressed in native and recombinant cell systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

21 August 2018

Guide to Receptors and Channels (GRAC), 4th Edition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144543

1 October 2018

Determination of hepatic blood flow in the rat using sequential infusions of indocyanine green or galactose

1 reference

https://pubmed.ncbi.nlm.nih.gov/21410458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ionic permeability of, and divalent cation effects on, two ATP-gated cation channels (P2X receptors) expressed in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21410458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peripheral adenosine 5'-triphosphate enhances nociception in the formalin test via activation of a purinergic p2X receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21410458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulatory roles of the adenosine triphosphate P2x-purinoceptor in generation of the persistent nociception induced by subcutaneous bee venom injection in the conscious rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/21410458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the development of allodynia by intrathecally administered P2 purinoceptor agonists and antagonists in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21410458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxic targeting of isolectin IB4-binding sensory neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21410458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanical allodynia caused by intraplantar injection of P2X receptor agonist in rats: involvement of heteromeric P2X2/3 receptor signaling in capsaicin-insensitive primary afferent neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21410458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1476-5381.2011.01322.X

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

ResearchGate publication ID

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