(Q42923060)

11 November 2017

title

Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats (English)

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11 November 2017

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11

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11 November 2017

Stephen B McMahon

12

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author name string

Timothy K Y Kaan

1

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11 November 2017

Ping K Yip

2

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11 November 2017

Sital Patel

3

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11 November 2017

Meirion Davies

4

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11 November 2017

Fabien Marchand

5

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11 November 2017

Debra A Cockayne

6

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11 November 2017

Philip A Nunn

7

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11 November 2017

Anthony H Dickenson

8

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11 November 2017

Anthony P D W Ford

9

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11 November 2017

Yu Zhong

10

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11 November 2017

language of work or name

English

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publication date

1 September 2010

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11 November 2017

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11 November 2017

volume

133

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11 November 2017

issue

9

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11 November 2017

page(s)

2549-2564

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The expression of P2X3 purinoreceptors in sensory neurons: effects of axotomy and glial-derived neurotrophic factor.

11 November 2017

cites work

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Parallel "pain" pathways arise from subpopulations of primary afferent nociceptor

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21 January 2018

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A unifying purinergic hypothesis for the initiation of pain.

21 January 2018

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Purinergic P2 receptors as targets for novel analgesics

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Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain

21 January 2018

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Electrophysiological characterization of spinal neuronal response properties in anaesthetized rats after ligation of spinal nerves L5-L6.

21 January 2018

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P2X receptors in sensory neurons co-cultured with cancer cells exhibit a decrease in opioid sensitivity.

21 January 2018

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P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide

21 January 2018

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P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP

21 January 2018

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Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice

21 January 2018

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The ERK 1 and 2 pathway in the nervous system: from basic aspects to possible clinical applications in pain and visceral dysfunction

21 January 2018

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Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons

21 January 2018

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The management of cancer-related breakthrough pain: recommendations of a task group of the Science Committee of the Association for Palliative Medicine of Great Britain and Ireland.

21 January 2018

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Translational medicine: cancer pain mechanisms and management

21 January 2018

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siRNA relieves chronic neuropathic pain

21 January 2018

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P2X receptors in peripheral neurons

21 January 2018

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Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat.

21 January 2018

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Pharmacology of P2X channels

21 January 2018

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AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist.

21 January 2018

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Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain.

21 January 2018

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Re-organization of P2X3 receptor localization on epidermal nerve fibers in a murine model of cancer pain.

21 January 2018

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Central neuronal mechanisms in cancer-induced bone pain.

21 January 2018

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A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone.

21 January 2018

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Analgesic profile of intrathecal P2X(3) antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats

21 January 2018

1 reference

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Long-term potentiation of neuronal excitation by neuron-glia interactions in the rat spinal dorsal horn.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat.

21 January 2018

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21 January 2018

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A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: therapeutic opportunity for treating skeletal pain.

21 January 2018

1 reference

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Endogenous purinergic control of bladder activity via presynaptic P2X3 and P2X2/3 receptors in the spinal cord.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Tumor-evoked hyperalgesia and sensitization of nociceptive dorsal horn neurons in a murine model of cancer pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

A decrease in anandamide signaling contributes to the maintenance of cutaneous mechanical hyperalgesia in a model of bone cancer pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Cancer pain and its impact on diagnosis, survival and quality of life

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Molecular mechanisms of cancer pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Effects of A‐317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

A rat model of bone cancer pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Malignant bone pain: pathophysiology and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Metastasis to bone: causes, consequences and therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Acidic microenvironment created by osteoclasts causes bone pain associated with tumor colonization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Mechanical allodynia and thermal hyperalgesia induced by experimental squamous cell carcinoma of the lower gingiva in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

MAPK activation in nociceptive neurons and pain hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Mechanical stress induces release of ATP from Ehrlich ascites tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Endothelin and the tumorigenic component of bone cancer pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Nerve growth factor induces P2X(3) expression in sensory neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Effects of the RANKL inhibitor, osteoprotegerin, on the pain and histopathology of bone cancer in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Bone cancer pain: the effects of the bisphosphonate alendronate on pain, skeletal remodeling, tumor growth and tumor necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Investigation into the role of P2X(3)/P2X(2/3) receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

In vivo single unit extracellular recordings from spinal cord neurones of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Alterations in dorsal horn neurones in a rat model of cancer-induced bone pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Efficacy of chronic morphine in a rat model of cancer-induced bone pain: behavior and in dorsal horn pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Disease modifying and anti-nociceptive effects of the bisphosphonate, zoledronic acid in a model of bone cancer pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Retinoic acid receptor beta2 promotes functional regeneration of sensory axons in the spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Rapid isolation and culture of primary microglia from adult mouse spinal cord.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

Validation of World Health Organization Guidelines for cancer pain relief: a 10-year prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ194

21 January 2018

Identifiers

DOI

10.1093/BRAIN/AWQ194

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11 November 2017

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