(Q39606523)

English

Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: application of N-heterocyclic carbene mediated acylations in complex molecule synthesis

scientific article published on 18 January 2011

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scholarly article

1 reference

Europe PubMed Central

13 September 2017

Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: application of N-heterocyclic carbene mediated acylations in complex molecule synthesis (English)

1 reference

Europe PubMed Central

13 September 2017

object named as

Bo Wang

1

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author name string

Po-Hsien Huang

2

1 reference

Europe PubMed Central

13 September 2017

Ching-Shih Chen

3

1 reference

Europe PubMed Central

13 September 2017

Craig J Forsyth

4

1 reference

Europe PubMed Central

13 September 2017

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publication date

18 January 2011

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Europe PubMed Central

13 September 2017

Journal of Organic Chemistry

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Europe PubMed Central

13 September 2017

76

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Europe PubMed Central

13 September 2017

4

1 reference

Europe PubMed Central

13 September 2017

1140-1150

1 reference

Europe PubMed Central

13 September 2017

Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201586

14 September 2017

Total synthesis and biological evaluation of largazole and derivatives with promising selectivity for cancers cells

1 reference

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alpha-Tocopheryl succinate and derivatives mediate the transcriptional repression of androgen receptor in prostate cancer cells by targeting the PP2A-JNK-Sp1-signaling axis

1 reference

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14 September 2017

Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold

1 reference

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Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole

1 reference

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14 September 2017

Enantioselective total synthesis of (+)-largazole, a potent inhibitor of histone deacetylase

1 reference

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14 September 2017

Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201586

14 September 2017

A concise total synthesis of largazole, solution structure, and some preliminary structure activity relationships

1 reference

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Targeting histone deacetylase in cancer therapy

1 reference

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Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

1 reference

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The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin.

1 reference

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A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

1 reference

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FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice

1 reference

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FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. II. Structure determination

1 reference

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FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity

1 reference

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Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A

1 reference

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14 September 2017

Synthesis and biological evaluation of c7-demethyl largazole analogues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201586

14 September 2017

Synthesis and activity of largazole analogues with linker and macrocycle modification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201586

14 September 2017

Synthesis and biological activity of largazole and derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201586

14 September 2017

Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp.

1 reference

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14 September 2017

Antitumor effects of a novel phenylbutyrate-based histone deacetylase inhibitor, (S)-HDAC-42, in prostate cancer

1 reference

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14 September 2017

Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes

1 reference

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14 September 2017

Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity.

1 reference

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14 September 2017

Structural specificity for biological activity of trichostatin A, a specific inhibitor of mammalian cell cycle with potent differentiation-inducing activity in Friend leukemia cells

1 reference

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17 June 2018

Total synthesis and molecular target of largazole, a histone deacetylase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201586

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N-heterocyclic carbene-catalyzed redox amidations of alpha-functionalized aldehydes with amines

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Nucleophilic carbene and HOAt relay catalysis in an amide bond coupling: an orthogonal peptide bond forming reaction

1 reference

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First asymmetric total synthesis of synerazol, an antifungal antibiotic, and determination of its absolute stereochemistry

1 reference

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Catalytic generation of activated carboxylates: direct, stereoselective synthesis of beta-hydroxyesters from epoxyaldehydes.

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Peptide-embedded heterocycles by mild single and multiple Aza-Wittig ring closures

1 reference

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Total synthesis of apratoxin A

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Synthesis of the Apratoxin 2,4-Disubstituted Thiazoline via an Intramolecular Aza-Wittig Reaction

1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/21244075

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Enantioselective synthesis of alpha-methyl-D-cysteine and lanthionine building blocks via alpha-methyl-D-serine-beta-lactone

1 reference

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Identifiers

10.1021/JO102478X

1 reference

Europe PubMed Central

13 September 2017

1 reference

Europe PubMed Central

13 September 2017

1 reference

Europe PubMed Central

13 September 2017

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