(Q39619024)

13 September 2017

title

Understanding the intracellular effect of enhanced nutrient feeding toward high titer antibody production process (English)

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13 September 2017

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Marcella Yu

1

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13 September 2017

Zhilan Hu

2

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13 September 2017

Efren Pacis

3

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13 September 2017

Natarajan Vijayasankaran

4

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13 September 2017

Amy Shen

5

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13 September 2017

Feng Li

6

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13 September 2017

publication date

19 February 2011

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Biotechnology and Bioengineering

13 September 2017

published in

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13 September 2017

volume

108

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13 September 2017

issue

5

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13 September 2017

page(s)

1078-1088

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Identification of novel small molecule enhancers of protein production by cultured mammalian cells

13 September 2017

cites work

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Mammalian cell factories for efficient and stable protein expression

21 January 2018

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An XBP-1 dependent bottle-neck in production of IgG subtype antibodies in chemically defined serum-free Chinese hamster ovary (CHO) fed-batch processes

21 January 2018

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High-level expression of full-length antibodies using trans-complementing expression vectors

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Engineering of a mammalian cell line for reduction of lactate formation and high monoclonal antibody production

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Metabolomics-driven approach for the improvement of Chinese hamster ovary cell growth: overexpression of malate dehydrogenase II.

21 January 2018

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Correlation of heavy and light chain mRNA copy numbers to antibody productivity in mouse myeloma production cell lines

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Mechanisms of unintended amino acid sequence changes in recombinant monoclonal antibodies expressed in Chinese Hamster Ovary (CHO) cells

21 January 2018

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Maximizing productivity of CHO cell‐based fed‐batch culture using chemically defined media conditions and typical manufacturing equipment

21 January 2018

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Effects of lactate dehydrogenase suppression and glycerol-3-phosphate dehydrogenase overexpression on cellular metabolism

21 January 2018

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Regulation of recombinant monoclonal antibody production in chinese hamster ovary cells: a comparative study of gene copy number, mRNA level, and protein expression.

21 January 2018

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Detailed understanding of enhanced specific antibody productivity in NS0 myeloma cells

21 January 2018

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Metabolic characterization of a hyper-productive state in an antibody producing NS0 myeloma cell line

21 January 2018

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Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin

21 January 2018

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A clone screening method using mRNA levels to determine specific productivity and product quality for monoclonal antibodies

21 January 2018

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High-level production of recombinant proteins in CHO cells using a dicistronic DHFR intron expression vector

21 January 2018

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Effects of temperature shift on cell cycle, apoptosis and nucleotide pools in CHO cell batch cultues

21 January 2018

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Cell line-specific control of recombinant monoclonal antibody production by CHO cells.

21 January 2018

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Combining caspase and mitochondrial dysfunction inhibitors of apoptosis to limit cell death in mammalian cell cultures.

21 January 2018

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CHO gene expression profiling in biopharmaceutical process analysis and design

21 January 2018

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On the optimal ratio of heavy to light chain genes for efficient recombinant antibody production by CHO cells.

21 January 2018

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In pursuit of a super producer-alternative paths to high producing recombinant mammalian cells

21 January 2018

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Molecular portrait of high productivity in recombinant NS0 cells

21 January 2018

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Dynamic analysis of GS-NS0 cells producing a recombinant monoclonal antibody during fed-batch culture.

21 January 2018

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Enhanced human thrombopoietin production by sodium butyrate addition to serum-free suspension culture of bcl-2-overexpressing CHO cells

21 January 2018

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Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity

21 January 2018

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Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange

21 January 2018

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Production of recombinant protein therapeutics in cultivated mammalian cells

21 January 2018

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Generation of stable cell lines by site-specific integration of transgenes into engineered Chinese hamster ovary strains using an FLP-FRT system

21 January 2018

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Effects of elevated pCO2 and osmolality on growth of CHO cells and production of antibody-fusion protein B1: a case study

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIT.23031

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13 September 2017

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