(Q39646906)

13 September 2017

title

Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology (English)

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13 September 2017

Matthew B Robers

1

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13 September 2017

Christine Loh

2

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13 September 2017

Coby B Carlson

3

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13 September 2017

Hongying Yang

4

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13 September 2017

Elizabeth A Frey

5

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13 September 2017

Spencer B Hermanson

6

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13 September 2017

Kun Bi

7

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13 September 2017

publication date

8 October 2010

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13 September 2017

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13 September 2017

volume

7

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13 September 2017

issue

1

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13 September 2017

page(s)

59-66

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The complexity of p53 stabilization and activation

13 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1039%2FC0MB00026D

How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?

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Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks

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Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0MB00026D

Acetylation is indispensable for p53 activation

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0MB00026D

21 January 2018

Modes of p53 regulation

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https://api.crossref.org/works/10.1039%2FC0MB00026D

Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0MB00026D

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0MB00026D

Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0MB00026D

Biological and potential therapeutic roles of sirtuin deacetylases

21 January 2018

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Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

21 January 2018

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Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3'-kinase/Akt pathway and Bcl-2 family proteins

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SirT1 is an inhibitor of proliferation and tumor formation in colon cancer

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Sirtuins--novel therapeutic targets to treat age-associated diseases

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The critical role of the class III histone deacetylase SIRT1 in cancer

21 January 2018

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High-throughput cellular assays for regulated posttranslational modifications

21 January 2018

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Development of LanthaScreen cellular assays for key components within the PI3K/AKT/mTOR pathway

21 January 2018

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Characterization of serotonin 5-hydroxytryptamine-1A receptor activation using a phospho-extracellular-signal regulated kinase 2 sensor

21 January 2018

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Cellular LanthaScreen and beta-lactamase reporter assays for high-throughput screening of JAK2 inhibitors

21 January 2018

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The genetics of the p53 pathway, apoptosis and cancer therapy

21 January 2018

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Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

21 January 2018

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Sirtuins (histone deacetylases III) in the cellular response to DNA damage--facts and hypotheses

21 January 2018

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

21 January 2018

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Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition?

21 January 2018

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SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.

21 January 2018

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Mechanism of human SIRT1 activation by resveratrol

21 January 2018

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Developing assays for kinase drug discovery - where have the advances come from?

21 January 2018

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Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells

21 January 2018

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Implementation of BacMam virus gene delivery technology in a drug discovery setting

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0MB00026D

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0MB00026D

HIPK2 modulates p53 activity towards pro-apoptotic transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0MB00026D

BacMam recombinant baculoviruses in G protein-coupled receptor drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0MB00026D

21 January 2018

Identifiers

DOI

10.1039/C0MB00026D

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13 September 2017

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