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The complexity of p53 stabilization and activation
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1 reference
stated in
Europe PubMed Central
PubMed ID
16601750
retrieved
14 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
The complexity of p53 stabilization and activation
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
16601750
retrieved
14 August 2017
author name string
M F Lavin
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
16601750
retrieved
14 August 2017
N Gueven
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
16601750
retrieved
14 August 2017
publication date
1 June 2006
1 reference
stated in
Europe PubMed Central
PubMed ID
16601750
retrieved
14 August 2017
published in
Cell Death & Differentiation
1 reference
stated in
Europe PubMed Central
PubMed ID
16601750
retrieved
14 August 2017
volume
13
1 reference
stated in
Europe PubMed Central
PubMed ID
16601750
retrieved
14 August 2017
page(s)
941-950
1 reference
stated in
Europe PubMed Central
PubMed ID
16601750
retrieved
14 August 2017
issue
6
1 reference
stated in
Europe PubMed Central
PubMed ID
16601750
retrieved
14 August 2017
exact match
https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401925
0 references
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On the road to cancer: aneuploidy and the mitotic checkpoint
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
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The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: influence of tumor site, type of mutation, and adjuvant treatment
1 reference
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P53 in cancer: a paradigm for modern management of cancer
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
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The p53 tumour suppressor gene
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
based on heuristic
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Role of p53 in sensing oxidative DNA damage in response to reactive oxygen species-generating agents
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
based on heuristic
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Cooperation between BRCA1 and p53 in repair of cyclobutane pyrimidine dimers
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
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Regulation of p53 in response to DNA damage
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
based on heuristic
inferred from DOI database lookup
The p53 pathway: positive and negative feedback loops
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
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UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
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Hypoxia links ATR and p53 through replication arrest
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
based on heuristic
inferred from DOI database lookup
p53-Dependent accelerated senescence induced by ionizing radiation in breast tumour cells
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
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Does the ribosome translate cancer?
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
based on heuristic
inferred from DOI database lookup
BRCA1 physically associates with p53 and stimulates its transcriptional activity.
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
based on heuristic
inferred from DOI database lookup
A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
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inferred from DOI database lookup
Activation of p53 protein by telomeric (TTAGGG)n repeats
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p53 story: layers of complexity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhanced phosphorylation of p53 by ATM in response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATM associates with and phosphorylates p53: mapping the region of interaction
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reactivation of mutant p53: a new strategy for cancer therapy.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recruitment of p300/CBP in p53-dependent signal pathways
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage activates p53 through a phosphorylation-acetylation cascade
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
based on heuristic
inferred from DOI database lookup
P53 and PML: new partners in tumor suppression
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
based on heuristic
inferred from DOI database lookup
Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
based on heuristic
inferred from DOI database lookup
Why is p53 acetylated?
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and characterization of the IKKalpha promoter: positive and negative regulation by ETS-1 and p53, respectively
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
based on heuristic
inferred from DOI database lookup
The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
based on heuristic
inferred from DOI database lookup
Acetylation of p53 inhibits its ubiquitination by Mdm2.
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Post-translational modifications and activation of p53 by genotoxic stresses
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation site interdependence of human p53 post-translational modifications in response to stress
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
based on heuristic
inferred from DOI database lookup
The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pinning a change on p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53-Mdm2--the affair that never ends
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATM-dependent CHK2 activation induced by anticancer agent, irofulven
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MDM2 interacts with MDMX through their RING finger domains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MdmX protects p53 from Mdm2-mediated degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutual dependence of MDM2 and MDMX in their functional inactivation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell cycle control, DNA damage checkpoints and cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ataxia-telangiectasia: a multifaceted genetic disorder associated with defective signal transduction
1 reference
stated in
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The two edges of the ATM sword: co-operation between repair and checkpoint functions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prognostic value of p53 mutations in patients with locally advanced esophageal carcinoma treated with definitive chemoradiotherapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage-induced phosphorylation of p53 at serine 20 correlates with p21 and Mdm-2 induction in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stabilization of alanine substituted p53 protein at Ser15, Thr18, and Ser20 in response to ionizing radiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A dynamic role of HAUSP in the p53-Mdm2 pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 proteasomal degradation: poly-ubiquitination is not the whole story
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of p53 serine 15 increases interaction with CBP
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A new effector pathway links ATM kinase with the DNA damage response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of p53 activity through lysine methylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nucleophosmin regulates the stability and transcriptional activity of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cleavage of poly(ADP-ribose) transferase during p53-independent apoptosis in rat liver after treatment with N-nitrosomorpholine and cyproterone acetate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.CDD.4401925
1 reference
stated in
Europe PubMed Central
PubMed ID
16601750
retrieved
14 August 2017
PubMed ID
16601750
1 reference
stated in
Europe PubMed Central
PubMed ID
16601750
retrieved
14 August 2017
ResearchGate publication ID
7177569
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