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DNA damage-induced phosphorylation of p53 at serine 20 correlates with p21 and Mdm-2 induction in vivo
scientific article published on 01 December 2000
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Europe PubMed Central
PubMed publication ID
11175334
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175334%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
title
DNA damage-induced phosphorylation of p53 at serine 20 correlates with p21 and Mdm-2 induction in vivo
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11175334
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175334%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
author name string
J R Jabbur
series ordinal
1
1 reference
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Europe PubMed Central
PubMed publication ID
11175334
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175334%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
P Huang
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2
1 reference
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Europe PubMed Central
PubMed publication ID
11175334
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175334%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
W Zhang
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3
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Europe PubMed Central
PubMed publication ID
11175334
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175334%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
language of work or name
English
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publication date
1 December 2000
1 reference
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Europe PubMed Central
PubMed publication ID
11175334
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175334%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
published in
Oncogene
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11175334
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175334%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
volume
19
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11175334
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175334%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
issue
54
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11175334
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175334%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
page(s)
6203-6208
1 reference
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Europe PubMed Central
PubMed publication ID
11175334
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175334%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
exact match
https://scigraph.springernature.com/pub.10.1038/sj.onc.1204017
0 references
cites work
Regulation of p53 function and stability by phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhanced phosphorylation of p53 by ATM in response to DNA damage
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of p53 downstream genes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The complexity of p53 modulation: emerging patterns from divergent signals
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a sequence element from p53 that signals for Mdm2-targeted degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 promotes the rapid degradation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RB regulates the stability and the apoptotic function of p53 via MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p38MAPK inhibitor SB203580 alleviates ultraviolet-induced phosphorylation at serine 389 but not serine 15 and activation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential p53 phosphorylation and activation of apoptosis-promoting genes Bax and Fas/APO-1 by irradiation and ara-C treatment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of p53 stability by Mdm2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of Mdm2-directed degradation by the C terminus of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of p53 serine 15 increases interaction with CBP
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human TAFII31 protein is a transcriptional coactivator of the p53 protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signaling to p53: breaking the MDM2-p53 circuit
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage activates p53 through a phosphorylation-acetylation cascade
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage induces phosphorylation of the amino terminus of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A role for ATR in the DNA damage-induced phosphorylation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The alpha-helical FXXPhiPhi motif in p53: TAF interaction and discrimination by MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p53-mdm-2 autoregulatory feedback loop
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A temperature-sensitive mutant of human p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204017
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.ONC.1204017
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11175334
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175334%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
Dimensions Publication ID
1042778065
0 references
PubMed publication ID
11175334
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11175334
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175334%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
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