(Q39655631)

13 September 2017

title

HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones (English)

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13 September 2017

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Michel J Vos

1

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13 September 2017

Marianne P Zijlstra

2

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13 September 2017

Bart Kanon

3

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13 September 2017

Maria A W H van Waarde-Verhagen

4

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13 September 2017

Ewout R P Brunt

5

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13 September 2017

Hendrika M J Oosterveld-Hut

6

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13 September 2017

Serena Carra

7

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13 September 2017

Ody C M Sibon

8

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13 September 2017

Harm H Kampinga

9

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13 September 2017

publication date

15 September 2010

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13 September 2017

published in

Human Molecular Genetics

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13 September 2017

volume

19

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13 September 2017

issue

23

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13 September 2017

page(s)

4677-4693

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Trinucleotide Repeat Disorders

13 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Structural and functional diversities between members of the human HSPB, HSPH, HSPA, and DNAJ chaperone families.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Hsp105alpha suppresses the aggregation of truncated androgen receptor with expanded CAG repeats and cell toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Heat-shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase: clues to a possible strategy for treating ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

A Drosophila ortholog of the human MRJ modulates polyglutamine toxicity and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Modulation of polyglutamine inclusion formation by the Hsp70 chaperone machine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Hsp27 and Hsp70 administered in combination have a potent protective effect against FALS-associated SOD1-mutant-induced cell death in mammalian neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

HspB8, a small heat shock protein mutated in human neuromuscular disorders, has in vivo chaperone activity in cultured cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

HspB8 participates in protein quality control by a non-chaperone-like mechanism that requires eIF2{alpha} phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Binding of non-native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Alpha-crystallin can function as a molecular chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Differences in the chaperone-like activities of the four main small heat shock proteins of Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Refolding of substrates bound to small Hsps relies on a disaggregation reaction mediated most efficiently by ClpB/DnaK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Small heat shock proteins inhibit amyloid-beta protein aggregation and cerebrovascular amyloid-beta protein toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Co-chaperones are limiting in a depleted chaperone network

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

New insights into the pathoanatomy of spinocerebellar ataxia type 3 (Machado-Joseph disease).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Identification and characterization of cvHsp. A novel human small stress protein selectively expressed in cardiovascular and insulin-sensitive tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

HSPB7 is a SC35 speckle resident small heat shock protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Evolutionary diversity of vertebrate small heat shock proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

A chaperone pathway in protein disaggregation. Hsp26 alters the nature of protein aggregates to facilitate reactivation by Hsp104.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Regulation of stress-induced intracellular sorting and chaperone function of Hsp27 (HspB1) in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Chaperone activity of cytosolic small heat shock proteins from wheat

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Multiple effects of trehalose on protein folding in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Alpha-crystallin-type heat shock proteins: socializing minichaperones in the context of a multichaperone network.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Bag-1M accelerates nucleotide release for human Hsc70 and Hsp70 and can act concentration-dependent as positive and negative cofactor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Hsp40 molecules that target to the ubiquitin-proteasome system decrease inclusion formation in models of polyglutamine disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

The dynamics of Hsp25 quaternary structure. Structure and function of different oligomeric species

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Discovery of Atg5/Atg7-independent alternative macroautophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

The splicing factor SC35 has an active role in transcriptional elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Huntington's disease--like 2 is associated with CUG repeat-containing RNA foci

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

A comparison of huntington disease and huntington disease-like 2 neuropathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

RNA toxicity is a component of ataxin-3 degeneration in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Repeat expansion disease: progress and puzzles in disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Comparison of intra-organellar chaperone capacity for dealing with stress-induced protein unfolding

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ398

21 January 2018

Identifiers

DOI

10.1093/HMG/DDQ398

1 reference

13 September 2017

1 reference