(Q40147054)

17 September 2017

title

Hsp40 molecules that target to the ubiquitin-proteasome system decrease inclusion formation in models of polyglutamine disease (English)

1 reference

ubiquitin-proteasome system

17 September 2017

main subject

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author

Michael E. Cheetham

9

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17 September 2017

J L Howarth

1

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17 September 2017

S Kelly

2

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17 September 2017

M P Keasey

3

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17 September 2017

C P J Glover

4

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17 September 2017

Y-B Lee

5

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17 September 2017

K Mitrophanous

6

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17 September 2017

J P Chapple

7

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17 September 2017

J M Gallo

8

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17 September 2017

J B Uney

10

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17 September 2017

language of work or name

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10 April 2007

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17 September 2017

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17 September 2017

volume

15

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17 September 2017

issue

6

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17 September 2017

page(s)

1100-1105

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Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox

17 September 2017

cites work

1 reference

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7 January 2021

Polyglutamines placed into context

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Pathogenesis of polyglutamine disorders: aggregation revisited

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Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse

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A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

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The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

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7 January 2021

Cell death in polyglutamine diseases

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Interaction of expanded polyglutamine stretches with nuclear transcription factors leads to aberrant transcriptional regulation in polyglutamine diseases

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7 January 2021

Mechanisms of cell death in polyglutamine expansion diseases

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7 January 2021

Unfolding the role of protein misfolding in neurodegenerative diseases

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7 January 2021

Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein

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7 January 2021

Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis.

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7 January 2021

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

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7 January 2021

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease

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A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration.

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7 January 2021

Huntingtin inclusions do not deplete polyglutamine-containing transcription factors in HD mice

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7 January 2021

Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

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7 January 2021

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

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7 January 2021

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

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7 January 2021

Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1.

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7 January 2021

Regulation of the heat-shock protein 70 reaction cycle by the mammalian DnaJ homolog, Hsp40.

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7 January 2021

Cells in stress: transcriptional activation of heat shock genes

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7 January 2021

Modulation of in vivo HSP70 chaperone activity by Hip and Bag-1.

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7 January 2021

A role of HSPs in apoptosis through "protein triage"?

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7 January 2021

Ubiquitylation of BAG-1 suggests a novel regulatory mechanism during the sorting of chaperone substrates to the proteasome

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7 January 2021

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300163

7 January 2021

Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling

1 reference

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7 January 2021

Cooperation of molecular chaperones with the ubiquitin/proteasome system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300163

7 January 2021

CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation

1 reference

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7 January 2021

The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome

1 reference

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7 January 2021

Neuronal DnaJ proteins HSJ1a and HSJ1b: a role in linking the Hsp70 chaperone machine to the ubiquitin-proteasome system?

1 reference

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7 January 2021

Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300163

7 January 2021

BAG-1 associates with the polyglutamine-expanded huntingtin aggregates.

1 reference

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7 January 2021

HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300163

7 January 2021

Regulation of 70-kDa heat-shock-protein ATPase activity and substrate binding by human DnaJ-like proteins, HSJ1a and HSJ1b

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300163

7 January 2021

Truncated forms of the androgen receptor are associated with polyglutamine expansion in X-linked spinal and bulbar muscular atrophy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300163

7 January 2021

Ligand-dependent aggregation of polyglutamine-expanded androgen receptor in neuronal cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300163

7 January 2021

BAG-1--a nucleotide exchange factor of Hsc70 with multiple cellular functions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300163

7 January 2021

Methods for construction of adenovirus vectors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300163

7 January 2021

Switching transgene expression in the brain using an adenoviral tetracycline-regulatable system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300163

7 January 2021

Lentiviral-mediated delivery of Bcl-2 or GDNF protects against excitotoxicity in the rat hippocampus

1 reference

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7 January 2021

The Chaperone Environment at the Cytoplasmic Face of the Endoplasmic Reticulum Can Modulate Rhodopsin Processing and Inclusion Formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300163

7 January 2021

Identifiers

DOI

10.1038/SJ.MT.6300163

1 reference

17 September 2017

1 reference