(Q39657540)

English

Isoprenoid biosynthetic pathway inhibition disrupts monoclonal protein secretion and induces the unfolded protein response pathway in multiple myeloma cells

scientific article published on 9 September 2010

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Isoprenoid biosynthetic pathway inhibition disrupts monoclonal protein secretion and induces the unfolded protein response pathway in multiple myeloma cells (English)

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

multiple myeloma

1 reference

based on heuristic

inferred from title

author name string

Sarah A Holstein

1

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Raymond J Hohl

2

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

publication date

9 September 2010

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

number of pages

9

1 reference

based on heuristic

inferred from page(s)

Leukemia Research

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

35

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

4

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

551-559

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3038195/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Regulation of secretory vesicle traffic by Rab small GTPases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

14 September 2017

HMG-CoA reductase inhibitor simvastatin overcomes bortezomib-induced apoptosis resistance by disrupting a geranylgeranyl pyrophosphate-dependent survival pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

14 September 2017

The endoplasmic reticulum and the unfolded protein response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

14 September 2017

Mechanism of action, pharmacokinetic and pharmacodynamic profile, and clinical applications of nitrogen-containing bisphosphonates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

14 September 2017

Building an antibody factory: a job for the unfolded protein response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

14 September 2017

Membrane targeting of Rab GTPases is influenced by the prenylation motif

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

14 September 2017

Rapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

14 September 2017

More than 1,000 putative new human signalling proteins revealed by EST data mining

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

14 September 2017

Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

14 September 2017

Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

14 September 2017

Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

14 September 2017

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

14 September 2017

Differential activities of thalidomide and isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

14 September 2017

The HMG-CoA inhibitor, simvastatin, triggers in vitro anti-tumour effect and decreases IgM secretion in Waldenstrom macroglobulinaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

14 September 2017

Zoledronate has an antitumor effect and induces actin rearrangement in dexamethasone-resistant myeloma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

14 September 2017

Statins reduce amyloid-beta production through inhibition of protein isoprenylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

14 September 2017

Synthesis and biological activity of isoprenoid bisphosphonates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

14 September 2017

Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

14 September 2017

Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

25 September 2017

Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

25 September 2017

Cleavage of calnexin caused by apoptotic stimuli: implication for the regulation of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

17 June 2018

Simultaneous determination of farnesyl and geranylgeranyl pyrophosphate levels in cultured cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

17 June 2018

Effect of farnesyl transferase inhibitor R115777 on the growth of fresh and cloned myeloma cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

17 June 2018

Geranylgeranyl transferase type II inhibition prevents myeloma bone disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

21 August 2018

Selective inhibition of Rab prenylation by a phosphonocarboxylate analogue of risedronate induces apoptosis, but not S-phase arrest, in human myeloma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

21 August 2018

Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

21 August 2018

Inhibition of protein geranylgeranylation induces apoptosis in myeloma plasma cells by reducing Mcl-1 protein levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

21 August 2018

Isoprenoids influence expression of Ras and Ras-related proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

21 August 2018

The cholesterol lowering drug lovastatin induces cell death in myeloma plasma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

21 August 2018

Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038195

21 August 2018

Lovastatin is a potent inhibitor of cholecystokinin secretion in endocrine tumor cells in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/20828814

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/20828814

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antisense approach in amyloid light chain amyloidosis: identification of monoclonal Ig and inhibition of its production by antisense oligonucleotides in in vitro and in vivo models

1 reference

https://pubmed.ncbi.nlm.nih.gov/20828814

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for the unfolded protein response in optimizing antibody secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/20828814

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20828814

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20828814

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/20828814

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

First clinical experience with simvastatin to overcome drug resistance in refractory multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20828814

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.LEUKRES.2010.08.008

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q39657540&oldid=1851893251"