(Q39660802)

English

Norepinephrine promotes microglia to uptake and degrade amyloid beta peptide through upregulation of mouse formyl peptide receptor 2 and induction of insulin-degrading enzyme.

scientific article published on September 2010

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13 February 2020

Norepinephrine promotes microglia to uptake and degrade amyloid beta peptide through upregulation of mouse formyl peptide receptor 2 and induction of insulin-degrading enzyme (English)

1 reference

Europe PubMed Central

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13 February 2020

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5

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13 February 2020

author name string

Yan Kong

1

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13 February 2020

Lingfei Ruan

2

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13 February 2020

Lihua Qian

3

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13 February 2020

Xiaolei Liu

4

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13 February 2020

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publication date

1 September 2010

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13 February 2020

Journal of Neuroscience

1 reference

Europe PubMed Central

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13 February 2020

30

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Europe PubMed Central

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13 February 2020

35

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Europe PubMed Central

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13 February 2020

11848-11857

1 reference

Europe PubMed Central

PMC publication ID

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13 February 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6633413/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Microglia as mediators of inflammatory and degenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translating cell biology into therapeutic advances in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased JNK, AP-1 and NF-kappa B DNA binding activities in isoproterenol-induced cardiac remodeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complement component C1q modulates the phagocytosis of Abeta by microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-adrenergic agonists exert their "anti-inflammatory" effects in monocytic cells through the IkappaB/NF-kappaB pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met is a potent chemotactic agonist for mouse formyl peptide receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracerebral regulation of immune responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bacterial lipopolysaccharide selectively up-regulates the function of the chemotactic peptide receptor formyl peptide receptor 2 in murine microglial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease-do tauists and baptists finally shake hands?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated microglia in Alzheimer's disease and stroke.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of FPR2, a chemotactic receptor for amyloid beta 1-42 (A beta 42), in murine microglial cells by TNF alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Existence of functional beta1- and beta2-adrenergic receptors on microglia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formyl-peptide receptors revisited

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of norepinephrine on rat cultured microglial cells that express alpha1, alpha2, beta1 and beta2 adrenergic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-adrenergic stimulation induces interleukin-18 expression via beta2-AR, PI3K, Akt, IKK, and NF-kappaB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of microglial inflammatory responses by norepinephrine: effects on nitric oxide and interleukin-1beta production

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: the amyloid cascade hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine and noradrenaline control distinct functions in rodent microglial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Norepinephrine protects cortical neurons against microglial-induced cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catecholamines mediate stress-induced increases in peripheral and central inflammatory cytokines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CpG-containing oligodeoxynucleotide promotes microglial cell uptake of amyloid beta 1-42 peptide by up-regulating the expression of the G-protein- coupled receptor mFPR2

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta-degrading enzymes: modulators of Alzheimer's disease pathogenesis and targets for therapeutic intervention

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

9-Cis-retinoic acid suppresses inflammatory responses of microglia and astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain macrophages: evaluation of microglia and their functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The involvement of norepinephrine and microglia in hypothalamic and splenic IL-1beta responses to stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of toll-like receptor signalling in Abeta uptake and clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of STAT3 by G alpha(s) distinctively requires protein kinase A, JNK, and phosphatidylinositol 3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of the formyl peptide receptor 2 in microglia by IFN-gamma and synergy with CD40 ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tricine-SDS-PAGE.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production and purification of lentiviral vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of glucose-induced expression of pancreatic-derived factor in pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia-neuron interaction in inflammatory and degenerative diseases: role of cholinergic and noradrenergic systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional consequences of locus coeruleus degeneration in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ApoE promotes the proteolytic degradation of Abeta

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel protein kinase A-independent, beta-arrestin-1-dependent signaling pathway for p38 mitogen-activated protein kinase activation by beta2-adrenergic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta2 Adrenergic receptor activation induces microglial NADPH oxidase activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits leukocyte activation by bacterial formylpeptide through the receptor FPR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adrenoceptors in brain: cellular gene expression and effects on astrocytic metabolism and [Ca(2+)]i

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia in the neurohypophysis associate with and endocytose terminal portions of neurosecretory neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal degeneration in locus ceruleus and cortical correlates of Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of nerve cells from locus coeruleus in Alzheimer's disease is topographically arranged.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Participation of cAMP and cAMP-dependent protein kinase in beta-adrenoceptor-mediated interleukin-1 beta mRNA induction in cultured microglia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histochemical characterization of a neocortical projection of the nucleus locus coeruleus in the squirrel monkey.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of interferon-gamma-induced major histocompatibility complex class II and Fc receptor expression on isolated microglia by transforming growth factor-beta 1, interleukin-4, noradrenaline and glucocorticoids.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia: a sensor for pathological events in the CNS

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial response to amyloid plaques in APPsw transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial-neuronal interactions in Alzheimer's disease: the potential role of a 'cytokine cycle' in disease progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.2985-10.2010

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20810904%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20810904%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20810904%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

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