(Q39661482)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20805790%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis (English)

1 reference

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13 February 2020

0 references

2

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13 February 2020

Luciane C Alberici

5

1 reference

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13 February 2020

H C Oliveira

6

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13 February 2020

Edgard Graner

10

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13 February 2020

author name string

Karina G Zecchin

1

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13 February 2020

Helena F Raposo

3

1 reference

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13 February 2020

Daniela R Melo

4

1 reference

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13 February 2020

Roger F Castilho

7

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13 February 2020

Ricardo D Coletta

8

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13 February 2020

Aníbal E Vercesi

9

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13 February 2020

publication date

30 August 2010

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13 February 2020

published in

Laboratory Investigation

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13 February 2020

volume

91

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13 February 2020

issue

2

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13 February 2020

page(s)

232-240

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https://scigraph.springernature.com/pub.10.1038/labinvest.2010.157

13 February 2020

exact match

0 references

cites work

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Quaternary structure of human fatty acid synthase by electron cryomicroscopy

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Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology

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Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival

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Delineation of prognostic biomarkers in prostate cancer

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High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB.

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Inhibition of fatty acid synthase by Orlistat accelerates gastric tumor cell apoptosis in culture and increases survival rates in gastric tumor bearing mice in vivo

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Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells

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Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity

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Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice

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Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells

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Key role of mitochondria in cerulenin-mediated apoptosis

21 January 2018

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Inhibition of the phosphatidylinositol 3-kinase/Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis.

21 January 2018

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Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model

21 January 2018

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A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.

21 January 2018

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Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells

21 January 2018

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Deoxycholate induces mitochondrial oxidative stress and activates NF-kappaB through multiple mechanisms in HCT-116 colon epithelial cells

21 January 2018

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High Bcl-2/Bax ratio in Walker tumor cells protects mitochondria but does not prevent H2O2-induced apoptosis via calcineurin pathways

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Fluorescence measurement and photochemical manipulation of cytosolic free calcium

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Mitochondria and apoptosis

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Mechanisms of cytochrome c release from mitochondria

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Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells

21 January 2018

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Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene

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Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

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Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival

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Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer

21 January 2018

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Suppression or induction of apoptosis by opposing pathways downstream from calcium-activated calcineurin

21 January 2018

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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

21 January 2018

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Mitochondrial permeability transition and oxidative stress

21 January 2018

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Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity

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A pilot study of fatty acid metabolism in oral squamous cell carcinoma.

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Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers

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Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase

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Fatty acid synthase expression in melanoma

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7 January 2021

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7 January 2021

Gastrointestinal stromal tumours overexpress fatty acid synthase

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7 January 2021

Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021